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    DMP1 dentin matrix acidic phosphoprotein 1 [ Homo sapiens (human) ]

    Gene ID: 1758, updated on 15-Nov-2015
    Official Symbol
    DMP1provided by HGNC
    Official Full Name
    dentin matrix acidic phosphoprotein 1provided by HGNC
    Primary source
    HGNC:HGNC:2932
    See related
    Ensembl:ENSG00000152592 HPRD:02989; MIM:600980; Vega:OTTHUMG00000130598
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARHP; ARHR; DMP-1
    Summary
    Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    4q21
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 4 NC_000004.12 (87650302..87664361)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (88571454..88585513)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene SPARC like 1 Neighboring gene uncharacterized LOC105377322 Neighboring gene dentin sialophosphoprotein Neighboring gene uncharacterized LOC105377323 Neighboring gene uncharacterized LOC105377324 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene 7

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • ECM proteoglycans, organism-specific biosystem (from REACTOME)
      ECM proteoglycans, organism-specific biosystemProteoglycans are major components of the extracellular matrix. In cartilage the matrix constitutes more than 90% of tissue dry weight. Proteoglycans are proteins substituted with glycosaminoglycans ...
    • Extracellular matrix organization, organism-specific biosystem (from REACTOME)
      Extracellular matrix organization, organism-specific biosystemThe extracellular matrix is a component of all mammalian tissues, a network consisting largely of the fibrous proteins collagen, elastin and associated-microfibrils, fibronectin and laminins embedded...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    calcium ion binding TAS
    Traceable Author Statement
    more info
    PubMed 
    extracellular matrix binding IEA
    Inferred from Electronic Annotation
    more info
     
    integrin binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    biomineral tissue development IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular matrix organization TAS
    Traceable Author Statement
    more info
     
    ossification IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell-substrate adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular region TAS
    Traceable Author Statement
    more info
     
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    nucleolus IDA
    Inferred from Direct Assay
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
     
    proteinaceous extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    dentin matrix acidic phosphoprotein 1
    Names
    dentin matrix protein 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008988.1 RefSeqGene

      Range
      5001..19060
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001079911.2NP_001073380.1  dentin matrix acidic phosphoprotein 1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001073380.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an internal in-frame exon, compared to variant 1, resulting in a protein (isoform 2) that is 16 aa shorter than isoform 1.
      Source sequence(s)
      AC093895, AI371158, U65378
      Consensus CDS
      CCDS43249.1
      UniProtKB/Swiss-Prot
      Q13316
      Related
      ENSP00000282479, OTTHUMP00000218558, ENST00000282479, OTTHUMT00000361347
      Conserved Domains (1) summary
      pfam07263
      Location:1497
      DMP1; Dentin matrix protein 1 (DMP1)
    2. NM_004407.3NP_004398.1  dentin matrix acidic phosphoprotein 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_004398.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC093895, AI371158, U89012
      Consensus CDS
      CCDS3623.1
      UniProtKB/Swiss-Prot
      Q13316
      Related
      ENSP00000340935, OTTHUMP00000161172, ENST00000339673, OTTHUMT00000253047
      Conserved Domains (1) summary
      pfam07263
      Location:1513
      DMP1; Dentin matrix protein 1 (DMP1)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p2 Primary Assembly

      Range
      87650302..87664361
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011531705.1XP_011530007.1  

      Conserved Domains (1) summary
      pfam07263
      Location:30542
      DMP1; Dentin matrix protein 1 (DMP1)
    2. XM_011531706.1XP_011530008.1  

      Conserved Domains (1) summary
      pfam07263
      Location:30526
      DMP1; Dentin matrix protein 1 (DMP1)

    Alternate CHM1_1.1

    Genomic

    1. NC_018915.2 Alternate CHM1_1.1

      Range
      88548218..88562278
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)