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AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 [ Homo sapiens (human) ]

Gene ID: 116986, updated on 4-May-2015
Official Symbol
AGAP2provided by HGNC
Official Full Name
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2provided by HGNC
Primary source
HGNC:HGNC:16921
See related
Ensembl:ENSG00000135439; HPRD:05687; MIM:605476; Vega:OTTHUMG00000170285
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PIKE; GGAP2; CENTG1
Summary
The protein encoded by this gene belongs to the centaurin gamma-like family. It mediates anti-apoptotic effects of nerve growth factor by activating nuclear phosphoinositide 3-kinase. It is overexpressed in cancer cells, and promotes cancer cell invasion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Orthologs
See AGAP2 in MapViewer
Location:
12q14.1
Exon count:
20
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 12 NC_000012.12 (57723761..57742201, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (58117544..58135984, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L13a pseudogene 23 Neighboring gene osteosarcoma amplified 9, endoplasmic reticulum lectin Neighboring gene AGAP2 antisense RNA 1 Neighboring gene tetraspanin 31 Neighboring gene microRNA 6759 Neighboring gene cyclin-dependent kinase 4

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
NHGRI GWA Catalog

Replication interactions

Interaction Pubs
Knockdown of ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 (AGAP2) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

  • Axon guidance, organism-specific biosystem (from REACTOME)
    Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • Endocytosis, organism-specific biosystem (from KEGG)
    Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Endocytosis, conserved biosystem (from KEGG)
    Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • FoxO signaling pathway, organism-specific biosystem (from KEGG)
    FoxO signaling pathway, organism-specific biosystemThe forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative str...
  • Netrin-1 signaling, organism-specific biosystem (from REACTOME)
    Netrin-1 signaling, organism-specific biosystemNetrins are secreted proteins that play a crucial role in neuronal migration and in axon guidance during the development of the nervous system. To date, several Netrins have been described in mouse a...
  • Prolactin Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Prolactin Signaling Pathway, organism-specific biosystemProlactin (PRL), a pleiotropic polypeptide hormone, mostly secreted by the lactotrophic cells of anterior pituitary gland and to a lesser extent expressed in numerous extra pituitary tissues such as ...
  • Trk receptor signaling mediated by PI3K and PLC-gamma, organism-specific biosystem (from Pathway Interaction Database)
    Trk receptor signaling mediated by PI3K and PLC-gamma, organism-specific biosystem
    Trk receptor signaling mediated by PI3K and PLC-gamma
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ16430, KIAA0167

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
axon guidance TAS
Traceable Author Statement
more info
 
negative regulation of neuron apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Preferred Names
arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2
Names
arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2
Arf GAP with GTP-binding protein-like, ANK repeat and PH domains 2
GTP-binding and GTPase activating protein 2
centaurin, gamma 1
cnt-g1
phosphatidylinositol 3-kinase enhancer
phosphatidylinositol-3-kinase enhancer
phosphoinositide 3-kinase enhancer

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029755.1 RefSeqGene

    Range
    5001..22869
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001122772.2NP_001116244.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform PIKE-L

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (PIKE-L). This isoform is thought to participate in the prevention of neuronal apoptosis by enhancing nuclear phosphoinositide 3-kinase activity (PMID:14528310).
    Source sequence(s)
    AC025165, AV740795, AY128689, BE280072, BI755875, D79989
    Consensus CDS
    CCDS44932.1
    UniProtKB/TrEMBL
    F8VVT9
    UniProtKB/Swiss-Prot
    Q99490
    Conserved Domains (6) summary
    cd04103
    Location:407566
    Centaurin_gamma; Centaurin gamma (CENTG) GTPase
    cd00204
    Location:10581147
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd01250
    Location:674914
    PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
    pfam00071
    Location:411566
    Ras; Ras family
    pfam01412
    Location:9331046
    ArfGap; Putative GTPase activating protein for Arf
    pfam12796
    Location:10581148
    Ank_2; Ankyrin repeats (3 copies)
  2. NM_014770.3NP_055585.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform PIKE-A

    See identical proteins and their annotated locations for NP_055585.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon compared to variant 1. This results in a shorter isoform (PIKE-A) with a distinct N-terminus compared to isoform PIKE-L. This isoform is reported to be overexpressed in brain tumors and promote cancer cell invasion (PMID:14761976).
    Source sequence(s)
    AV740795, BE280072, BI755875, D79989, DB165417
    Consensus CDS
    CCDS8951.1
    UniProtKB/TrEMBL
    A0A024RB55
    UniProtKB/Swiss-Prot
    Q99490
    Related
    ENSP00000257897, OTTHUMP00000243438, ENST00000257897, OTTHUMT00000408366
    Conserved Domains (6) summary
    cd04103
    Location:71230
    Centaurin_gamma; Centaurin gamma (CENTG) GTPase
    cd00204
    Location:702791
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd01250
    Location:338558
    PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
    pfam00071
    Location:75230
    Ras; Ras family
    pfam01412
    Location:577690
    ArfGap; Putative GTPase activating protein for Arf
    pfam12796
    Location:702792
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p2 Primary Assembly

    Range
    57723761..57742201
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005268626.1XP_005268683.1  

    See identical proteins and their annotated locations for XP_005268683.1

    Conserved Domains (6) summary
    cd04103
    Location:71230
    Centaurin_gamma; Centaurin gamma (CENTG) GTPase
    cd00204
    Location:722811
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd01250
    Location:338578
    PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
    pfam00071
    Location:75230
    Ras; Ras family
    pfam01412
    Location:597710
    ArfGap; Putative GTPase activating protein for Arf
    pfam12796
    Location:722812
    Ank_2; Ankyrin repeats (3 copies)
  2. XM_005268625.2XP_005268682.1  

    Conserved Domains (6) summary
    cd04103
    Location:407566
    Centaurin_gamma; Centaurin gamma (CENTG) GTPase
    cd00204
    Location:10381127
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd01250
    Location:674894
    PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
    pfam00071
    Location:411566
    Ras; Ras family
    pfam01412
    Location:9131026
    ArfGap; Putative GTPase activating protein for Arf
    pfam12796
    Location:10381128
    Ank_2; Ankyrin repeats (3 copies)

RNA

  1. XR_245891.2 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 Alternate CHM1_1.1

    Range
    58085878..58103748
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)