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PBK PDZ binding kinase [ Homo sapiens (human) ]

Gene ID: 55872, updated on 19-Jul-2014
Official Symbol
PBKprovided by HGNC
Official Full Name
PDZ binding kinaseprovided by HGNC
Primary source
HGNC:18282
See related
Ensembl:ENSG00000168078; HPRD:17822; MIM:611210; Vega:OTTHUMG00000102113
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPK; CT84; TOPK; HEL164; Nori-3
Summary
This gene encodes a serine/threonine protein kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. The encoded protein may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis. Overexpression of this gene has been implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Location:
8p21.2
Exon count :
8
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 8 NC_000008.11 (27809621..27838095, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (27667138..27695612, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene microRNA 3622b Neighboring gene microRNA 3622a Neighboring gene coiled-coil domain containing 25 Neighboring gene establishment of sister chromatid cohesion N-acetyltransferase 2 Neighboring gene TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa pseudogene Neighboring gene scavenger receptor class A, member 5 Neighboring gene microRNA 4287

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
mitotic nuclear division NAS
Non-traceable Author Statement
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
Preferred Names
lymphokine-activated killer T-cell-originated protein kinase
Names
lymphokine-activated killer T-cell-originated protein kinase
cancer/testis antigen 84
MAPKK-like protein kinase
epididymis luminal protein 164
serine/threonine protein kinase
T-LAK cell-originated protein kinase
spermatogenesis-related protein kinase
NP_001265874.1
NP_060962.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278945.1NP_001265874.1  lymphokine-activated killer T-cell-originated protein kinase isoform 2

    See proteins identical to NP_001265874.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is longer, compared to isoform 1.
    Source sequence(s)
    AK301836, BC015191, DB028500
    Consensus CDS
    CCDS64858.1
    UniProtKB/Swiss-Prot
    Q96KB5
    Conserved Domains (2) summary
    cd00180
    Location:39254
    Blast Score: 346
    PKc; Catalytic domain of Protein Kinases
    pfam00069
    Location:34327
    Blast Score: 366
    Pkinase; Protein kinase domain
  2. NM_018492.3NP_060962.2  lymphokine-activated killer T-cell-originated protein kinase isoform 1

    See proteins identical to NP_060962.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript, and encodes the shorter isoform (1).
    Source sequence(s)
    BC015191, DB028500
    Consensus CDS
    CCDS6063.1
    UniProtKB/Swiss-Prot
    Q96KB5
    UniProtKB/TrEMBL
    V9HWH0
    Related
    ENSP00000301905, OTTHUMP00000128310, ENST00000301905, OTTHUMT00000219952
    Conserved Domains (2) summary
    cd00180
    Location:39243
    Blast Score: 359
    PKc; Catalytic domain of Protein Kinases
    pfam00069
    Location:34316
    Blast Score: 383
    Pkinase; Protein kinase domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000008.11 

    Range
    27809621..27838095
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006716368.1XP_006716431.1  

    See proteins identical to XP_006716431.1

    UniProtKB/Swiss-Prot
    Q96KB5
    UniProtKB/TrEMBL
    V9HWH0
    Conserved Domains (2) summary
    cd00180
    Location:39243
    Blast Score: 359
    PKc; Catalytic domain of Protein Kinases
    pfam00069
    Location:34316
    Blast Score: 383
    Pkinase; Protein kinase domain

Alternate HuRef

Genomic

  1. AC_000140.1 

    Range
    26212013..26240449
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018919.2 

    Range
    27869078..27897509
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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