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TYMS thymidylate synthetase [ Homo sapiens (human) ]

Gene ID: 7298, updated on 5-Apr-2015
Official Symbol
TYMSprovided by HGNC
Official Full Name
thymidylate synthetaseprovided by HGNC
Primary source
HGNC:HGNC:12441
See related
Ensembl:ENSG00000176890; HPRD:01774; MIM:188350; Vega:OTTHUMG00000131473
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TS; TMS; HST422
Summary
Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. [provided by RefSeq, Jul 2008]
Orthologs
See TYMS in MapViewer
Location:
18p11.32
Exon count:
7
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 18 NC_000018.10 (657604..673499)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (657590..673499)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene centrin, EF-hand protein, 1 Neighboring gene clusterin-like 1 (retinal) Neighboring gene uncharacterized LOC105371952 Neighboring gene TYMS opposite strand Neighboring gene enolase superfamily member 1 Neighboring gene YES proto-oncogene 1, Src family tyrosine kinase Neighboring gene bolA family member 2 pseudogene 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC88736

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cofactor binding IEA
Inferred from Electronic Annotation
more info
 
drug binding IEA
Inferred from Electronic Annotation
more info
 
folic acid binding IEA
Inferred from Electronic Annotation
more info
 
mRNA binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
thymidylate synthase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
G1/S transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
aging IEA
Inferred from Electronic Annotation
more info
 
cartilage development IEA
Inferred from Electronic Annotation
more info
 
circadian rhythm IEA
Inferred from Electronic Annotation
more info
 
dTMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
dTTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
dUMP metabolic process IEA
Inferred from Electronic Annotation
more info
 
deoxyribonucleoside monophosphate biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
developmental growth IEA
Inferred from Electronic Annotation
more info
 
immortalization of host cell by virus IEA
Inferred from Electronic Annotation
more info
 
intestinal epithelial cell maturation IEA
Inferred from Electronic Annotation
more info
 
methylation IEA
Inferred from Electronic Annotation
more info
 
mitotic cell cycle TAS
Traceable Author Statement
more info
 
nucleobase-containing compound metabolic process TAS
Traceable Author Statement
more info
PubMed 
nucleobase-containing small molecule metabolic process TAS
Traceable Author Statement
more info
 
organ regeneration IEA
Inferred from Electronic Annotation
more info
 
pyrimidine nucleobase metabolic process TAS
Traceable Author Statement
more info
 
pyrimidine nucleoside biosynthetic process TAS
Traceable Author Statement
more info
 
regulation of transcription involved in G1/S transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
response to cytokine IEA
Inferred from Electronic Annotation
more info
 
response to drug IEA
Inferred from Electronic Annotation
more info
 
response to ethanol IEA
Inferred from Electronic Annotation
more info
 
response to folic acid IEA
Inferred from Electronic Annotation
more info
 
response to glucocorticoid IEA
Inferred from Electronic Annotation
more info
 
response to organophosphorus IEP
Inferred from Expression Pattern
more info
PubMed 
response to progesterone IEA
Inferred from Electronic Annotation
more info
 
response to toxic substance IEA
Inferred from Electronic Annotation
more info
 
response to vitamin A IEA
Inferred from Electronic Annotation
more info
 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
tetrahydrofolate metabolic process IEA
Inferred from Electronic Annotation
more info
 
uracil metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
thymidylate synthase
Names
thymidylate synthase
TSase
NP_001062.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028255.1 RefSeqGene

    Range
    5001..20896
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001071.2NP_001062.1  thymidylate synthase

    See proteins identical to NP_001062.1

    Status: REVIEWED

    Source sequence(s)
    AP001178, BC083512, X02308
    Consensus CDS
    CCDS11821.1
    UniProtKB/Swiss-Prot
    P04818
    UniProtKB/TrEMBL
    Q53Y97
    Related
    ENSP00000315644, OTTHUMP00000162195, ENST00000323274, OTTHUMT00000254316
    Conserved Domains (1) summary
    cd00351
    Location:32266
    TS_Pyrimidine_HMase; Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p2 Primary Assembly

    Range
    657604..673499
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018929.2 Alternate CHM1_1.1

    Range
    656968..672692
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)