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Prkaa2 protein kinase, AMP-activated, alpha 2 catalytic subunit [ Rattus norvegicus (Norway rat) ]

Gene ID: 78975, updated on 19-Jul-2014
Official Symbol
Prkaa2provided by RGD
Official Full Name
protein kinase, AMP-activated, alpha 2 catalytic subunitprovided by RGD
Primary source
RGD:620893
See related
Ensembl:ENSRNOG00000007706
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
Ampk; Ampka2
Summary
protein kinase that phosphorylates and inhibits acetyl-CoA carboxylase (ACC); rate-limiting enzyme in malonyl-CoA synthesis [RGD, Feb 2006]
See Prkaa2 in MapViewer
Location:
5q34
Exon count :
9
Annotation release Status Assembly Chr Location
104 current Rnor_5.0 (GCF_000001895.4) 5 NC_005104.3 (128436023..128503874, complement)

Chromosome 5 - NC_005104.3Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102549275 Neighboring gene similar to novel protein Neighboring gene metallothionein-2-like Neighboring gene phosphatidic acid phosphatase type 2B Neighboring gene uncharacterized LOC102549529 Neighboring gene uncharacterized LOC102549739

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
AMP-activated protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
AMP-activated protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
AMP-activated protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
[acetyl-CoA carboxylase] kinase activity IEA
Inferred from Electronic Annotation
more info
 
[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity IEA
Inferred from Electronic Annotation
more info
 
chromatin binding IEA
Inferred from Electronic Annotation
more info
 
chromatin binding ISO
Inferred from Sequence Orthology
more info
 
chromatin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
histone serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
histone serine kinase activity ISO
Inferred from Sequence Orthology
more info
 
histone serine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding, bridging IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein serine/threonine/tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
autophagy IEA
Inferred from Electronic Annotation
more info
 
cellular response to glucose starvation IEA
Inferred from Electronic Annotation
more info
 
cellular response to glucose starvation ISO
Inferred from Sequence Orthology
more info
 
cellular response to glucose starvation ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to nutrient levels ISO
Inferred from Sequence Orthology
more info
 
cellular response to nutrient levels ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to organonitrogen compound IEP
Inferred from Expression Pattern
more info
PubMed 
cholesterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
fatty acid homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 
glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
glucose homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
histone-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
histone-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
histone-serine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
lipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
lipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
lipid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of TOR signaling IEA
Inferred from Electronic Annotation
more info
 
negative regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
 
negative regulation of TOR signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of autophagy IEA
Inferred from Electronic Annotation
more info
 
positive regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
positive regulation of autophagy ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of glycolytic process IDA
Inferred from Direct Assay
more info
PubMed 
protein heterooligomerization IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of circadian rhythm IEA
Inferred from Electronic Annotation
more info
 
regulation of circadian rhythm ISO
Inferred from Sequence Orthology
more info
 
regulation of circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of energy homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
regulation of lipid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
response to activity IDA
Inferred from Direct Assay
more info
PubMed 
response to caffeine IDA
Inferred from Direct Assay
more info
PubMed 
rhythmic process IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
AMP-activated protein kinase complex IDA
Inferred from Direct Assay
more info
PubMed 
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
protein complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
5'-AMP-activated protein kinase catalytic subunit alpha-2
Names
5'-AMP-activated protein kinase catalytic subunit alpha-2
ACACA kinase
HMGCR kinase
AMPK alpha-2 chain
AMPK subunit alpha-2
AMP-activated protein kinase
acetyl-CoA carboxylase kinase
hydroxymethylglutaryl-CoA reductase kinase
NP_076481.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023991.1NP_076481.1  5'-AMP-activated protein kinase catalytic subunit alpha-2

    See proteins identical to NP_076481.1

    Status: PROVISIONAL

    Source sequence(s)
    Z29486
    UniProtKB/Swiss-Prot
    Q09137
    Related
    ENSRNOP00000010680, ENSRNOT00000010680
    Conserved Domains (3) summary
    cd05123
    Location:22268
    Blast Score: 609
    STKc_AGC; Catalytic domain of AGC family Protein Serine/Threonine Kinases
    cd12200
    Location:395550
    Blast Score: 471
    AMPKA2_C; C-terminal regulatory domain of 5'-AMP-activated serine/threonine kinase, subunit alpha
    smart00220
    Location:16268
    Blast Score: 814
    S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_5.0 Primary Assembly

Genomic

  1. NC_005104.3 

    Range
    128436023..128503874
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000073.1 

    Range
    118363351..118429630
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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