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Mre11a meiotic recombination 11 homolog A (S. cerevisiae) [ Mus musculus (house mouse) ]

Gene ID: 17535, updated on 19-Sep-2014
Official Symbol
Mre11aprovided by MGI
Official Full Name
meiotic recombination 11 homolog A (S. cerevisiae)provided by MGI
Primary source
MGI:MGI:1100512
Locus tag
RP23-149D5.3
See related
Ensembl:ENSMUSG00000031928; Vega:OTTMUSG00000031684
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mre11; Mre11b
See Mre11a in Epigenomics, MapViewer
Location:
9 A2; 9
Exon count:
22
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 9 NC_000075.6 (14784659..14837125)

Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700012B09 gene Neighboring gene ankyrin repeat domain 49 Neighboring gene transmembrane protein 223-like Neighboring gene predicted pseudogene 16379 Neighboring gene G protein-coupled receptor 83

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
3'-5' exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to ATP-dependent DNA helicase activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to DNA binding ISO
Inferred from Sequence Orthology
more info
 
endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
 
exonuclease activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
manganese ion binding IEA
Inferred from Electronic Annotation
more info
 
nuclease activity IEA
Inferred from Electronic Annotation
more info
 
protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
DNA duplex unwinding ISO
Inferred from Sequence Orthology
more info
 
DNA metabolic process IEA
Inferred from Electronic Annotation
more info
 
DNA repair IEA
Inferred from Electronic Annotation
more info
 
base-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
 
cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
PubMed 
chromosome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
double-strand break repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
intra-S DNA damage checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
meiotic nuclear division IEA
Inferred from Electronic Annotation
more info
 
mitotic G2 DNA damage checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of DNA endoreduplication ISO
Inferred from Sequence Orthology
more info
 
negative regulation of viral entry into host cell ISO
Inferred from Sequence Orthology
more info
 
nucleic acid phosphodiester bond hydrolysis IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleotide-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
sister chromatid cohesion ISO
Inferred from Sequence Orthology
more info
 
synapsis IMP
Inferred from Mutant Phenotype
more info
PubMed 
telomere maintenance IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
Mre11 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
Mre11 complex ISO
Inferred from Sequence Orthology
more info
 
chromatin IBA
Inferred from Biological aspect of Ancestor
more info
 
colocalizes_with chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
condensed nuclear chromosome ISO
Inferred from Sequence Orthology
more info
 
nuclear chromatin ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
site of double-strand break IBA
Inferred from Biological aspect of Ancestor
more info
 
site of double-strand break ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
double-strand break repair protein MRE11A
Names
double-strand break repair protein MRE11A
mmMRE11A
MRE11 homolog 1
MRE11 homolog A
meiotic recombination 11 homolog 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018736.2NP_061206.1  double-strand break repair protein MRE11A

    See proteins identical to NP_061206.1

    Status: PROVISIONAL

    Source sequence(s)
    BC065144
    Consensus CDS
    CCDS22827.1
    UniProtKB/TrEMBL
    Q3URU4
    UniProtKB/Swiss-Prot
    Q61216
    Related
    ENSMUSP00000034405, OTTMUSP00000041737, ENSMUST00000034405, OTTMUST00000078494
    Conserved Domains (3) summary
    cd00840
    Location:14275
    MPP_Mre11_N; Mre11 nuclease, N-terminal metallophosphatase domain
    TIGR00583
    Location:10402
    mre11; DNA repair protein (mre11)
    pfam04152
    Location:294462
    Mre11_DNA_bind; Mre11 DNA-binding presumed domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000075.6 

    Range
    14784659..14837125
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510050.1XP_006510113.1  

    See proteins identical to XP_006510113.1

    UniProtKB/Swiss-Prot
    Q61216
    Related
    ENSMUSP00000111295, OTTMUSP00000041738, ENSMUST00000115632, OTTMUST00000078495
    Conserved Domains (3) summary
    cd00840
    Location:14275
    MPP_Mre11_N; Mre11 nuclease, N-terminal metallophosphatase domain
    TIGR00583
    Location:10375
    mre11; DNA repair protein (mre11)
    pfam04152
    Location:294435
    Mre11_DNA_bind; Mre11 DNA-binding presumed domain
  2. XM_006510048.1XP_006510111.1  

    See proteins identical to XP_006510111.1

    UniProtKB/TrEMBL
    Q3URU4
    UniProtKB/Swiss-Prot
    Q61216
    Conserved Domains (3) summary
    cd00840
    Location:14275
    MPP_Mre11_N; Mre11 nuclease, N-terminal metallophosphatase domain
    TIGR00583
    Location:10402
    mre11; DNA repair protein (mre11)
    pfam04152
    Location:294462
    Mre11_DNA_bind; Mre11 DNA-binding presumed domain
  3. XM_006510049.1XP_006510112.1  

    See proteins identical to XP_006510112.1

    UniProtKB/Swiss-Prot
    Q61216
    Conserved Domains (3) summary
    cd00840
    Location:14275
    MPP_Mre11_N; Mre11 nuclease, N-terminal metallophosphatase domain
    TIGR00583
    Location:10375
    mre11; DNA repair protein (mre11)
    pfam04152
    Location:294435
    Mre11_DNA_bind; Mre11 DNA-binding presumed domain
  4. XM_006510051.1XP_006510114.1  

    Conserved Domains (3) summary
    cd00840
    Location:14221
    MPP_Mre11_N; Mre11 nuclease, N-terminal metallophosphatase domain
    TIGR00583
    Location:10340
    mre11; DNA repair protein (mre11)
    pfam04152
    Location:232400
    Mre11_DNA_bind; Mre11 DNA-binding presumed domain
  5. XM_006510052.1XP_006510115.1  

    Conserved Domains (2) summary
    cd00840
    Location:15172
    MPP_Mre11_N; Mre11 nuclease, N-terminal metallophosphatase domain
    pfam04152
    Location:191359
    Mre11_DNA_bind; Mre11 DNA-binding presumed domain
  6. XM_006510053.1XP_006510116.1  

    Conserved Domains (2) summary
    pfam04152
    Location:138306
    Mre11_DNA_bind; Mre11 DNA-binding presumed domain
    cl13995
    Location:3119
    MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
  7. XM_006510054.1XP_006510117.1  

    Conserved Domains (1) summary
    pfam04152
    Location:1169
    Mre11_DNA_bind; Mre11 DNA-binding presumed domain

RNA

  1. XR_379107.1 RNA Sequence

Alternate Mm_Celera

Genomic

  1. AC_000031.1 

    Range
    12065444..12115180
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)