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MAP3K3 mitogen-activated protein kinase kinase kinase 3 [ Homo sapiens (human) ]

Gene ID: 4215, updated on 7-Dec-2014
Official Symbol
MAP3K3provided by HGNC
Official Full Name
mitogen-activated protein kinase kinase kinase 3provided by HGNC
Primary source
HGNC:HGNC:6855
See related
Ensembl:ENSG00000198909; HPRD:03965; MIM:602539; Vega:OTTHUMG00000178905
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MEKK3; MAPKKK3
Summary
This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
See MAP3K3 in Epigenomics, MapViewer
Location:
17q23.3
Exon count:
17
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 17 NC_000017.11 (63622044..63696310)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (61699404..61773670)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene translational activator of mitochondrially encoded cytochrome c oxidase I Neighboring gene family with sequence similarity 136, member A pseudogene Neighboring gene eukaryotic translation elongation factor 1 delta pseudogene 7 Neighboring gene uncharacterized LOC101927898 Neighboring gene uncharacterized LOC729683 Neighboring gene LIM domain containing 2 Neighboring gene STE20-related kinase adaptor alpha

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study of body height in African Americans: the Women's Health Initiative SNP Health Association Resource (SHARe).
NHGRI GWA Catalog
Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry.
NHGRI GWA Catalog
Many sequence variants affecting diversity of adult human height.
NHGRI GWA Catalog
  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
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  • GnRH signaling pathway, organism-specific biosystem (from KEGG)
    GnRH signaling pathway, organism-specific biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
  • GnRH signaling pathway, conserved biosystem (from KEGG)
    GnRH signaling pathway, conserved biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
  • HTLV-I infection, organism-specific biosystem (from KEGG)
    HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
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  • IL1-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
    IL1-mediated signaling events, organism-specific biosystem
    IL1-mediated signaling events
  • Immune System, organism-specific biosystem (from REACTOME)
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  • MAPK Cascade, organism-specific biosystem (from WikiPathways)
    MAPK Cascade, organism-specific biosystem
    MAPK Cascade
  • MAPK signaling pathway, organism-specific biosystem (from KEGG)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
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    MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
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  • Regulation of p38-alpha and p38-beta, organism-specific biosystem (from Pathway Interaction Database)
    Regulation of p38-alpha and p38-beta, organism-specific biosystem
    Regulation of p38-alpha and p38-beta
  • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
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Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
MAP kinase kinase kinase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
MAPK cascade TAS
Traceable Author Statement
more info
PubMed 
activation of MAPKK activity IEA
Inferred from Electronic Annotation
more info
 
activation of MAPKK activity TAS
Traceable Author Statement
more info
PubMed 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling IEP
Inferred from Expression Pattern
more info
PubMed 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
Preferred Names
mitogen-activated protein kinase kinase kinase 3
Names
mitogen-activated protein kinase kinase kinase 3
MEKK 3
MEK kinase 3
MAP/ERK kinase kinase 3
MAPK/ERK kinase kinase 3
NP_002392.2
NP_976226.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002401.3NP_002392.2  mitogen-activated protein kinase kinase kinase 3 isoform 2

    See proteins identical to NP_002392.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame coding exon compared to variant 1. The resulting isoform (2) lacks an internal region, as compared to isoform 1.
    Source sequence(s)
    AL834303, BM728104, BM800091, BQ643432, BU633068
    Consensus CDS
    CCDS32702.1
    UniProtKB/Swiss-Prot
    Q99759
    Conserved Domains (3) summary
    cd06405
    Location:45123
    PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
    cd06625
    Location:359622
    STKc_MEKK3_like; Catalytic domain of MAP/ERK kinase kinase 3-like Protein Serine/Threonine Kinases
    smart00220
    Location:362621
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  2. NM_203351.1NP_976226.1  mitogen-activated protein kinase kinase kinase 3 isoform 1

    See proteins identical to NP_976226.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL834303, BM479726, BM728104, BM800091, BU633068
    Consensus CDS
    CCDS32701.1
    UniProtKB/Swiss-Prot
    Q99759
    Related
    ENSP00000354927, OTTHUMP00000260293, ENST00000361357, OTTHUMT00000443868
    Conserved Domains (3) summary
    cd06405
    Location:76154
    PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
    smart00220
    Location:393652
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06625
    Location:392652
    STKc_MEKK3_like; Catalytic domain of Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 3-like Serine/Threonine Kinases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000017.11 

    Range
    63622044..63696310
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005257376.1XP_005257433.1  

    See proteins identical to XP_005257433.1

    UniProtKB/TrEMBL
    J3QRB6
    Conserved Domains (3) summary
    cd06405
    Location:76154
    PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
    smart00220
    Location:389648
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06625
    Location:388648
    STKc_MEKK3_like; Catalytic domain of Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 3-like Serine/Threonine Kinases
  2. XM_005257378.1XP_005257435.1  

    Conserved Domains (3) summary
    cd06405
    Location:76154
    PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
    smart00220
    Location:393522
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl09925
    Location:390524
    PKc_like; Protein Kinases, catalytic domain
  3. XM_005257377.1XP_005257434.1  

    See proteins identical to XP_005257434.1

    UniProtKB/TrEMBL
    J3KRN4
    Conserved Domains (3) summary
    cd06405
    Location:45123
    PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
    smart00220
    Location:358617
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06625
    Location:357617
    STKc_MEKK3_like; Catalytic domain of Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 3-like Serine/Threonine Kinases
  4. XM_006721909.1XP_006721972.1  

    Conserved Domains (3) summary
    cd06625
    Location:274537
    STKc_MEKK3_like; Catalytic domain of MAP/ERK kinase kinase 3-like Protein Serine/Threonine Kinases
    smart00220
    Location:277536
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl02720
    Location:138
    PB1; The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 ...

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 

    Range
    61764216..61838082
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000149.1 

    Range
    57077975..57141816
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)