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    CYP2U1 cytochrome P450 family 2 subfamily U member 1 [ Homo sapiens (human) ]

    Gene ID: 113612, updated on 10-Dec-2015
    Official Symbol
    CYP2U1provided by HGNC
    Official Full Name
    cytochrome P450 family 2 subfamily U member 1provided by HGNC
    Primary source
    HGNC:HGNC:20582
    See related
    Ensembl:ENSG00000155016; HPRD:13109; MIM:610670; Vega:OTTHUMG00000161084
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SPG49; SPG56; P450TEC
    Summary
    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is a hydroxylase that metabolizes arachidonic acid, docosahexaenoic acid, and other long chain fatty acids. [provided by RefSeq, Jul 2008]
    Orthologs
    See CYP2U1 in Epigenomics, MapViewer
    Location:
    4q25
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 4 NC_000004.12 (107931549..107953461)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (108852716..108874617)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Neighboring gene uncharacterized LOC101929595 Neighboring gene sphingomyelin synthase 2 Neighboring gene hydroxyacyl-CoA dehydrogenase Neighboring gene lymphoid enhancer binding factor 1 Neighboring gene LEF1 antisense RNA 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    aromatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    heme binding IEA
    Inferred from Electronic Annotation
    more info
     
    iron ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    steroid hydroxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    arachidonic acid metabolic process TAS
    Traceable Author Statement
    more info
     
    omega-hydroxylase P450 pathway TAS
    Traceable Author Statement
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    small molecule metabolic process TAS
    Traceable Author Statement
    more info
     
    xenobiotic metabolic process TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    cytochrome P450 2U1
    Names
    cytochrome P450, family 2, subfamily U, polypeptide 1
    spastic paraplegia 49
    NP_898898.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007961.1 RefSeqGene

      Range
      5001..26897
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_183075.2NP_898898.1  cytochrome P450 2U1

      See identical proteins and their annotated locations for NP_898898.1

      Status: REVIEWED

      Source sequence(s)
      AK026498, AY343323, BU838483, BX354124, BX437421, CD672608
      Consensus CDS
      CCDS34047.1
      UniProtKB/Swiss-Prot
      Q7Z449
      Related
      ENSP00000333212, OTTHUMP00000219686, ENST00000332884, OTTHUMT00000363691
      Conserved Domains (1) summary
      pfam00067
      Location:60537
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p2 Primary Assembly

      Range
      107931549..107953461
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005262717.2XP_005262774.1  

      Conserved Domains (1) summary
      pfam00067
      Location:60555
      p450; Cytochrome P450
    2. XM_005262720.2XP_005262777.1  

      Conserved Domains (1) summary
      cl12078
      Location:164325
      p450; Cytochrome P450

    Alternate CHM1_1.1

    Genomic

    1. NC_018915.2 Alternate CHM1_1.1

      Range
      108829176..108851087
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)