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    Plp1 proteolipid protein (myelin) 1 [ Mus musculus (house mouse) ]

    Gene ID: 18823, updated on 25-Jul-2016
    Official Symbol
    Plp1provided by MGI
    Official Full Name
    proteolipid protein (myelin) 1provided by MGI
    Primary source
    MGI:MGI:97623
    See related
    Ensembl:ENSMUSG00000031425 Vega:OTTMUSG00000016519
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    jp; Plp; msd; rsh; DM20; jimpy
    Orthologs
    Location:
    X 59.1 cM; X F1-F2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (136822166..136838582)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (133357375..133372282)

    Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene mortality factor 4 like 2 Neighboring gene cDNA sequence BC065397 Neighboring gene glycine receptor, alpha 4 subunit Neighboring gene RAB9B, member RAS oncogene family Neighboring gene predicted gene 15026

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    structural constituent of myelin sheath ISO
    Inferred from Sequence Orthology
    more info
     
    structural molecule activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    astrocyte development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    axon development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    axon ensheathment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    central nervous system myelination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    inflammatory response IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    integrin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    long-chain fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    myelination IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    myelination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    myelination ISO
    Inferred from Sequence Orthology
    more info
     
    myelination TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    myelin sheath IDA
    Inferred from Direct Assay
    more info
    PubMed 
    myelin sheath ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    myelin proteolipid protein
    Names
    lipophilin
    myelin synthesis deficiency
    rump shaker

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290561.1NP_001277490.1  myelin proteolipid protein isoform 2

      See identical proteins and their annotated locations for NP_001277490.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AK160872, AL672008, BC027010, BY282535
      Consensus CDS
      CCDS72436.1
      UniProtKB/Swiss-Prot
      P60202
      UniProtKB/TrEMBL
      Q3UYM8
      Related
      ENSMUSP00000108708, OTTMUSP00000017801, ENSMUST00000113085, OTTMUST00000039924
      Conserved Domains (1) summary
      pfam01275
      Location:2242
      Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)
    2. NM_001290562.1NP_001277491.1  myelin proteolipid protein isoform 3

      See identical proteins and their annotated locations for NP_001277491.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK160872, AL672008, BC027010, BY282535
      UniProtKB/Swiss-Prot
      P60202
      UniProtKB/TrEMBL
      Q3UYM8
      Conserved Domains (1) summary
      cl02417
      Location:2207
      Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)
    3. NM_011123.3NP_035253.1  myelin proteolipid protein isoform 1

      See identical proteins and their annotated locations for NP_035253.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK160872, AL672008, BC027010, BY282535
      Consensus CDS
      CCDS30424.1
      UniProtKB/Swiss-Prot
      P60202
      UniProtKB/TrEMBL
      Q3UYM8
      Related
      ENSMUSP00000033800, OTTMUSP00000017800, ENSMUST00000033800, OTTMUST00000039923
      Conserved Domains (1) summary
      pfam01275
      Location:2277
      Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

      Range
      136822166..136838582
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017318431.1XP_017173920.1  

    2. XM_017318432.1XP_017173921.1  

    3. XM_017318430.1XP_017173919.1