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Il6 interleukin 6 [ Mus musculus (house mouse) ]

Gene ID: 16193, updated on 7-Apr-2015
Official Symbol
Il6provided by MGI
Official Full Name
interleukin 6provided by MGI
Primary source
MGI:MGI:96559
See related
Ensembl:ENSMUSG00000025746
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Il-6
Orthologs
See Il6 in MapViewer
Location:
5 B1; 5 15.7 cM
Exon count:
5
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 5 NC_000071.6 (30013161..30019968)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (30339701..30346508)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 10 pseudogene Neighboring gene vacuole membrane protein 1 pseudogene Neighboring gene RIKEN cDNA A230098N10 gene Neighboring gene uncharacterized LOC102640315 Neighboring gene thymidylate synthase

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
cytokine activity IDA
Inferred from Direct Assay
more info
PubMed 
cytokine activity ISO
Inferred from Sequence Orthology
more info
 
growth factor activity ISO
Inferred from Sequence Orthology
more info
 
interleukin-6 receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
interleukin-6 receptor binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to interleukin-6 receptor binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
T cell activation IGI
Inferred from Genetic Interaction
more info
PubMed 
T-helper 17 cell lineage commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
acute-phase response IEA
Inferred from Electronic Annotation
more info
 
branching involved in salivary gland morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
branching involved in salivary gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell growth ISO
Inferred from Sequence Orthology
more info
 
cell redox homeostasis ISO
Inferred from Sequence Orthology
more info
 
cellular response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
cellular response to interleukin-1 IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to tumor necrosis factor IDA
Inferred from Direct Assay
more info
PubMed 
cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
defense response to protozoan IMP
Inferred from Mutant Phenotype
more info
PubMed 
defense response to virus ISO
Inferred from Sequence Orthology
more info
 
endocrine pancreas development IMP
Inferred from Mutant Phenotype
more info
PubMed 
epithelial cell proliferation involved in salivary gland morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
glucagon secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
glucose homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
hepatic immune response ISO
Inferred from Sequence Orthology
more info
 
immune response IEA
Inferred from Electronic Annotation
more info
 
inflammatory response ISO
Inferred from Sequence Orthology
more info
 
interleukin-6-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
interleukin-6-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
muscle cell cellular homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
myeloid cell homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of chemokine biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of chemokine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of collagen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cytokine secretion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gluconeogenesis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of hormone secretion IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of muscle organ development ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
neuron projection development ISO
Inferred from Sequence Orthology
more info
 
neutrophil apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
neutrophil apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
neutrophil apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of B cell activation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of JAK-STAT cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of T-helper 2 cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of acute inflammatory response ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of chemokine production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of epithelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of immunoglobulin secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein import into nucleus, translocation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of sequence-specific DNA binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
positive regulation of translation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transmission of nerve impulse ISO
Inferred from Sequence Orthology
more info
 
positive regulation of tyrosine phosphorylation of Stat3 protein ISO
Inferred from Sequence Orthology
more info
 
regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of cell shape ISO
Inferred from Sequence Orthology
more info
 
regulation of circadian sleep/wake cycle, non-REM sleep ISO
Inferred from Sequence Orthology
more info
 
regulation of vascular endothelial growth factor production ISO
Inferred from Sequence Orthology
more info
 
response to glucocorticoid ISO
Inferred from Sequence Orthology
more info
 
response to wounding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cell IGI
Inferred from Genetic Interaction
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
interleukin-6 receptor complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
interleukin-6
Names
interleukin-6
B-cell hybridoma growth factor
interleukin HP-1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031168.1NP_112445.1  interleukin-6 precursor

    See proteins identical to NP_112445.1

    Status: PROVISIONAL

    Source sequence(s)
    X54542
    Consensus CDS
    CCDS19153.1
    UniProtKB/TrEMBL
    A2RTD1
    UniProtKB/Swiss-Prot
    P08505
    Related
    ENSMUSP00000026845, ENSMUST00000026845
    Conserved Domains (1) summary
    pfam00489
    Location:55209
    IL6; Interleukin-6/G-CSF/MGF family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000071.6 Reference GRCm38.p3 C57BL/6J

    Range
    30013161..30019968
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000027.1 Alternate Mm_Celera

    Range
    27530266..27537070
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)