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    TPM1 tropomyosin 1 (alpha) [ Homo sapiens (human) ]

    Gene ID: 7168, updated on 24-Apr-2016
    Official Symbol
    TPM1provided by HGNC
    Official Full Name
    tropomyosin 1 (alpha)provided by HGNC
    Primary source
    HGNC:HGNC:12010
    See related
    Ensembl:ENSG00000140416 HPRD:01839; MIM:191010; Vega:OTTHUMG00000132803
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CMH3; TMSA; CMD1Y; LVNC9; C15orf13; HEL-S-265; HTM-alpha
    Summary
    This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    15q22.1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 15 NC_000015.10 (63042639..63071915)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (63334838..63364114)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928955 Neighboring gene nuclease-sensitive element-binding protein 1 pseudogene Neighboring gene lactamase beta Neighboring gene ribosomal protein S27 like

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Professional guidelines

    Description
    Professional guideline
    ACMG 2013

    The ACMG recommends that laboratories performing clinical sequencing seek and report mutations in TPM1 that are pathogenic or expected to be pathogenic.

    GuidelinePubMed

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    No evidence available (Last evaluated (2015-11-09)

    ClinGen Genome Curation Page
    Triplosensitivity

    No evidence available (Last evaluated (2015-11-09)

    ClinGen Genome Curation Page

    NHGRI GWAS Catalog

    Description
    A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium.
    NHGRI GWA Catalog
    Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci.
    NHGRI GWA Catalog
    New gene functions in megakaryopoiesis and platelet formation.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    retropepsin gag-pol Exposure of human skin fibroblasts to HIV-1 protease induces the degradation of the vimentin filament network and the disappearance of the tropomyosin isoforms microfilament network PubMed
    gag-pol HIV-1 protease cleaves tropomyosin in vitro at positions 30, 51, and 87 PubMed

    Go to the HIV-1, Human Interaction Database

    • Adrenergic signaling in cardiomyocytes, organism-specific biosystem (from KEGG)
      Adrenergic signaling in cardiomyocytes, organism-specific biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
    • Adrenergic signaling in cardiomyocytes, conserved biosystem (from KEGG)
      Adrenergic signaling in cardiomyocytes, conserved biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
    • Cardiac muscle contraction, organism-specific biosystem (from KEGG)
      Cardiac muscle contraction, organism-specific biosystemContraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation...
    • Cardiac muscle contraction, conserved biosystem (from KEGG)
      Cardiac muscle contraction, conserved biosystemContraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation...
    • Dilated cardiomyopathy, organism-specific biosystem (from KEGG)
      Dilated cardiomyopathy, organism-specific biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
    • Dilated cardiomyopathy, conserved biosystem (from KEGG)
      Dilated cardiomyopathy, conserved biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
    • Hypertrophic cardiomyopathy (HCM), organism-specific biosystem (from KEGG)
      Hypertrophic cardiomyopathy (HCM), organism-specific biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
    • Hypertrophic cardiomyopathy (HCM), conserved biosystem (from KEGG)
      Hypertrophic cardiomyopathy (HCM), conserved biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
    • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
      MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
    • MicroRNAs in cancer, conserved biosystem (from KEGG)
      MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
    • Muscle contraction, organism-specific biosystem (from REACTOME)
      Muscle contraction, organism-specific biosystemIn this module, the processes by which calcium binding triggers actin - myosin interactions and force generation in smooth and striated muscle tissues are annotated.
    • Smooth Muscle Contraction, organism-specific biosystem (from REACTOME)
      Smooth Muscle Contraction, organism-specific biosystemLayers of smooth muscle cells can be found in the walls of numerous organs and tissues within the body. Smooth muscle tissue lacks the striated banding pattern characteristic of skeletal and cardiac ...
    • Striated Muscle Contraction, organism-specific biosystem (from REACTOME)
      Striated Muscle Contraction, organism-specific biosystemStriated muscle contraction is a process whereby force is generated within striated muscle tissue, resulting in a change in muscle geometry, or in short, increased force being exerted on the tendons....
    • Striated Muscle Contraction, organism-specific biosystem (from WikiPathways)
      Striated Muscle Contraction, organism-specific biosystemMuscle contraction is the process where muscle tissue is activated by a signal from the nervous system. In case of voluntary action the nervous signals are initiated from the brain by so called actio...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    actin binding TAS
    Traceable Author Statement
    more info
    PubMed 
    cytoskeletal protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    structural constituent of cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    structural constituent of muscle TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    cardiac muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to reactive oxygen species IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cytoskeleton organization TAS
    Traceable Author Statement
    more info
    PubMed 
    in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    movement of cell or subcellular component TAS
    Traceable Author Statement
    more info
    PubMed 
    muscle contraction TAS
    Traceable Author Statement
    more info
     
    muscle filament sliding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    muscle filament sliding TAS
    Traceable Author Statement
    more info
     
    negative regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    negative regulation of vascular associated smooth muscle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of vascular smooth muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of ATPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    positive regulation of cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    positive regulation of heart rate by epinephrine ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    positive regulation of stress fiber assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of heart contraction TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of muscle contraction TAS
    Traceable Author Statement
    more info
    PubMed 
    ruffle organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    sarcomere organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ventricular cardiac muscle tissue morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    wound healing ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Component Evidence Code Pubs
    bleb IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    filamentous actin IEA
    Inferred from Electronic Annotation
    more info
     
    muscle thin filament tropomyosin TAS
    Traceable Author Statement
    more info
    PubMed 
    ruffle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sarcomere TAS
    Traceable Author Statement
    more info
    PubMed 
    stress fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    tropomyosin alpha-1 chain
    Names
    alpha-tropomyosin
    cardiomyopathy, hypertrophic 3
    epididymis secretory protein Li 265
    sarcomeric tropomyosin kappa

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007557.1 RefSeqGene

      Range
      5001..28455
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000366.5NP_000357.3  tropomyosin alpha-1 chain isoform Tpm1.5cy

      See identical proteins and their annotated locations for NP_000357.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (Tpm1.5, also known as variant 5) contains an alternate, in-frame exon and uses an alternate in-frame splice site and upstream stop codon, compared to variant Tpm1.1. It encodes isoform Tpm1.5cy, which has a different C-terminus, compared to isoform Tpm1.1st.
      Source sequence(s)
      BC007433, BG107949, CN423344
      Consensus CDS
      CCDS10181.1
      UniProtKB/Swiss-Prot
      P09493
      UniProtKB/TrEMBL
      A0A0K0K1I0
      Related
      ENSP00000288398, OTTHUMP00000163688, ENST00000288398, OTTHUMT00000256220
      Conserved Domains (2) summary
      pfam00261
      Location:48284
      Tropomyosin; Tropomyosin
      pfam12718
      Location:7153
      Tropomyosin_1; Tropomyosin like
    2. NM_001018004.1NP_001018004.1  tropomyosin alpha-1 chain isoform Tpm1.6cy

      See identical proteins and their annotated locations for NP_001018004.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (Tpm1.6, also known as variant 3) contains an alternate, in-frame exon in the 3' coding region, compared to variant Tpm1.1. It encodes isoform Tpm1.6cy, also known as the TM-2 fibroblast isoform, which has a distinct C-terminus, compared to isoform Tpm1.1st.
      Source sequence(s)
      AC079328, AJ000147, BG107949
      Consensus CDS
      CCDS58369.1
      UniProtKB/Swiss-Prot
      P09493
      UniProtKB/TrEMBL
      O15513
      Related
      ENSP00000453941, OTTHUMP00000248051, ENST00000559556, OTTHUMT00000417089
      Conserved Domains (2) summary
      pfam00261
      Location:48284
      Tropomyosin; Tropomyosin
      pfam12718
      Location:7153
      Tropomyosin_1; Tropomyosin like
    3. NM_001018005.1NP_001018005.1  tropomyosin alpha-1 chain isoform Tpm1.1st

      See identical proteins and their annotated locations for NP_001018005.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (Tpm1.1, also known as variant 1) represents the shortest transcript. It encodes the longest isoform (Tpm1.1st), also known as the fast skeletal muscle isoform.
      Source sequence(s)
      BC007433, BG107949, M19713
      Consensus CDS
      CCDS45273.1
      UniProtKB/Swiss-Prot
      P09493
      UniProtKB/TrEMBL
      D9YZV4
      Related
      ENSP00000385107, OTTHUMP00000248048, ENST00000403994, OTTHUMT00000417083
      Conserved Domains (2) summary
      pfam00261
      Location:48284
      Tropomyosin; Tropomyosin
      pfam12718
      Location:7153
      Tropomyosin_1; Tropomyosin like
    4. NM_001018006.1NP_001018006.1  tropomyosin alpha-1 chain isoform Tpm1.7cy

      See identical proteins and their annotated locations for NP_001018006.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (Tpm1.7, also known as variant 4) contains alternate, in-frame exons in the 3' coding region, compared to variant Tpm1.1. It encodes isoform Tpm1.7cy, also known as the TM-3 fibroblast isoform, which has a distinct C-terminus, compared to isoform Tpm1.1st.
      Source sequence(s)
      AC079328, AJ000147, BG107949
      Consensus CDS
      CCDS32263.1
      UniProtKB/Swiss-Prot
      P09493
      UniProtKB/TrEMBL
      D9YZV5, O15513
      Related
      ENSP00000351022, OTTHUMP00000248046, ENST00000358278, OTTHUMT00000417081
      Conserved Domains (2) summary
      pfam00261
      Location:48284
      Tropomyosin; Tropomyosin
      pfam12718
      Location:7153
      Tropomyosin_1; Tropomyosin like
    5. NM_001018007.1NP_001018007.1  tropomyosin alpha-1 chain isoform Tpm1.4sm

      See identical proteins and their annotated locations for NP_001018007.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (Tpm1.4, also known as variant 2) contains alternate, in-frame exons in the 5' and 3' coding region, compared to variant Tpm1.1. It encodes isoform Tpm1.4sm, also known as the smooth muscle isoform, which has distinct N- and C-termini, compared to isoform Tpm1.1st.
      Source sequence(s)
      AL050179, BG107949
      Consensus CDS
      CCDS32262.1
      UniProtKB/Swiss-Prot
      P09493
      UniProtKB/TrEMBL
      A0A024R5W6
      Related
      ENSP00000267996, OTTHUMP00000248053, ENST00000267996, OTTHUMT00000417091
      Conserved Domains (2) summary
      pfam00261
      Location:48284
      Tropomyosin; Tropomyosin
      pfam12718
      Location:7153
      Tropomyosin_1; Tropomyosin like
    6. NM_001018008.1NP_001018008.1  tropomyosin alpha-1 chain isoform Tpm1.12br

      See identical proteins and their annotated locations for NP_001018008.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (Tpm1.12, also known as variant 6) contains alternate in-frame exons in the 5' and 3' coding region, compared to variant Tpm1.1. It encodes isoform Tpm1.12br, also known as the TMBr-3 brain isoform, which has distinct N- and C-termini and is shorter than isoform Tpm1.1st.
      Source sequence(s)
      AC079328, BC050473, BC053545
      Consensus CDS
      CCDS32264.1
      UniProtKB/Swiss-Prot
      P09493
      UniProtKB/TrEMBL
      D9YZV7
      Related
      ENSP00000334624, OTTHUMP00000248057, ENST00000334895, OTTHUMT00000417095
      Conserved Domains (2) summary
      pfam00261
      Location:12244
      Tropomyosin; Tropomyosin
      pfam12718
      Location:12117
      Tropomyosin_1; Tropomyosin like
    7. NM_001018020.1NP_001018020.1  tropomyosin alpha-1 chain isoform Tpm1.3sm

      See identical proteins and their annotated locations for NP_001018020.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (Tpm1.3, also known as variant 7) contains alternate, in-frame exons in the coding region, compared to variant Tpm1.1. It encodes isoform Tpm1.3sm, which has distinct N- and C-termini, compared to isoform Tpm1.1st.
      Source sequence(s)
      AC079328, AJ000147, BG107949, BX458841
      Consensus CDS
      CCDS58368.1
      UniProtKB/Swiss-Prot
      P09493
      UniProtKB/TrEMBL
      O15513
      Related
      ENSP00000452879, OTTHUMP00000248052, ENST00000559397, OTTHUMT00000417090
      Conserved Domains (2) summary
      pfam00261
      Location:48284
      Tropomyosin; Tropomyosin
      pfam12718
      Location:7153
      Tropomyosin_1; Tropomyosin like
    8. NM_001301244.1NP_001288173.1  tropomyosin alpha-1 chain isoform Tpm1.2st

      See identical proteins and their annotated locations for NP_001288173.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (Tpm1.2, also known as variant 8) contains an alternate, in-frame exon in the 5' coding region, compared to variant Tpm1.1. It encodes isoform Tpm1.2st, which has a distinct N-terminus, compared to isoform Tpm1.1st.
      Source sequence(s)
      AY640414, CD679271, CN423297
      UniProtKB/Swiss-Prot
      P09493
      Conserved Domains (2) summary
      pfam00261
      Location:48284
      Tropomyosin; Tropomyosin
      pfam12718
      Location:7153
      Tropomyosin_1; Tropomyosin like
    9. NM_001301289.1NP_001288218.1  tropomyosin alpha-1 chain isoform Tpm1.8cy

      See identical proteins and their annotated locations for NP_001288218.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (Tpm1.8, also known as variant 9) contains alternate in-frame exons in the 5' and 3' coding region, compared to variant Tpm1.1. It encodes isoform Tpm1.8cy, which has distinct N- and C-termini and is shorter than isoform Tpm1.1st.
      Source sequence(s)
      AC079328
      UniProtKB/TrEMBL
      B7Z722
      Conserved Domains (2) summary
      pfam00261
      Location:12248
      Tropomyosin; Tropomyosin
      pfam12718
      Location:12117
      Tropomyosin_1; Tropomyosin like

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p2 Primary Assembly

      Range
      63042639..63071915
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006720667.2XP_006720730.1  

      See identical proteins and their annotated locations for XP_006720730.1

      UniProtKB/Swiss-Prot
      P09493
      Conserved Domains (2) summary
      pfam00261
      Location:48284
      Tropomyosin; Tropomyosin
      pfam12718
      Location:7153
      Tropomyosin_1; Tropomyosin like
    2. XM_005254645.1XP_005254702.1  

      See identical proteins and their annotated locations for XP_005254702.1

      Conserved Domains (2) summary
      pfam00261
      Location:48280
      Tropomyosin; Tropomyosin
      pfam12718
      Location:7153
      Tropomyosin_1; Tropomyosin like
    3. XM_005254639.2XP_005254696.1  

      See identical proteins and their annotated locations for XP_005254696.1

      Conserved Domains (2) summary
      pfam00261
      Location:48259
      Tropomyosin; Tropomyosin
      pfam12718
      Location:7153
      Tropomyosin_1; Tropomyosin like
    4. XM_005254638.2XP_005254695.1  

      See identical proteins and their annotated locations for XP_005254695.1

      Conserved Domains (2) summary
      pfam00261
      Location:48259
      Tropomyosin; Tropomyosin
      pfam12718
      Location:7153
      Tropomyosin_1; Tropomyosin like
    5. XM_005254637.1XP_005254694.1  

      See identical proteins and their annotated locations for XP_005254694.1

      UniProtKB/TrEMBL
      Q6ZN40
      Related
      ENSP00000350667, OTTHUMP00000248049, ENST00000357980, OTTHUMT00000417087
      Conserved Domains (2) summary
      pfam00261
      Location:90326
      Tropomyosin; Tropomyosin
      pfam12718
      Location:7195
      Tropomyosin_1; Tropomyosin like
    6. XM_005254641.2XP_005254698.1  

      See identical proteins and their annotated locations for XP_005254698.1

      Conserved Domains (2) summary
      pfam00261
      Location:48259
      Tropomyosin; Tropomyosin
      pfam12718
      Location:7153
      Tropomyosin_1; Tropomyosin like
    7. XM_005254640.2XP_005254697.1  

      See identical proteins and their annotated locations for XP_005254697.1

      Conserved Domains (2) summary
      pfam00261
      Location:48259
      Tropomyosin; Tropomyosin
      pfam12718
      Location:7153
      Tropomyosin_1; Tropomyosin like
    8. XM_006720669.2XP_006720732.1  

      Conserved Domains (2) summary
      pfam00261
      Location:1133
      Tropomyosin; Tropomyosin
      pfam12718
      Location:13134
      Tropomyosin_1; Tropomyosin like
    9. XM_005254652.1XP_005254709.1  

      See identical proteins and their annotated locations for XP_005254709.1

      UniProtKB/TrEMBL
      H7BYY1
      Related
      ENSP00000384315, OTTHUMP00000248058, ENST00000404484, OTTHUMT00000417096
      Conserved Domains (2) summary
      pfam00261
      Location:12248
      Tropomyosin; Tropomyosin
      pfam12718
      Location:12117
      Tropomyosin_1; Tropomyosin like
    10. XM_005254653.1XP_005254710.1  

      See identical proteins and their annotated locations for XP_005254710.1

      UniProtKB/TrEMBL
      F5H7S3
      Related
      ENSP00000322577, OTTHUMP00000248061, ENST00000317516, OTTHUMT00000417101
      Conserved Domains (2) summary
      pfam00261
      Location:12244
      Tropomyosin; Tropomyosin
      pfam12718
      Location:12117
      Tropomyosin_1; Tropomyosin like
    11. XM_005254650.2XP_005254707.1  

      See identical proteins and their annotated locations for XP_005254707.1

      Conserved Domains (2) summary
      pfam00261
      Location:12248
      Tropomyosin; Tropomyosin
      pfam12718
      Location:12117
      Tropomyosin_1; Tropomyosin like
    12. XM_005254647.2XP_005254704.1  

      See identical proteins and their annotated locations for XP_005254704.1

      Related
      ENSP00000452658, OTTHUMP00000248060, ENST00000559281, OTTHUMT00000417100
      Conserved Domains (2) summary
      pfam00261
      Location:12223
      Tropomyosin; Tropomyosin
      pfam12718
      Location:12117
      Tropomyosin_1; Tropomyosin like
    13. XM_005254651.1XP_005254708.1  

      See identical proteins and their annotated locations for XP_005254708.1

      Conserved Domains (2) summary
      pfam00261
      Location:12248
      Tropomyosin; Tropomyosin
      pfam12718
      Location:12117
      Tropomyosin_1; Tropomyosin like
    14. XM_005254648.1XP_005254705.1  

      See identical proteins and their annotated locations for XP_005254705.1

      Conserved Domains (2) summary
      pfam00261
      Location:12248
      Tropomyosin; Tropomyosin
      pfam12718
      Location:12117
      Tropomyosin_1; Tropomyosin like
    15. XM_005254646.1XP_005254703.1  

      See identical proteins and their annotated locations for XP_005254703.1

      UniProtKB/TrEMBL
      B7Z596
      Related
      ENSP00000453724, OTTHUMP00000248586, ENST00000560959, OTTHUMT00000417099
      Conserved Domains (2) summary
      pfam00261
      Location:12226
      Tropomyosin; Tropomyosin
      pfam12718
      Location:12117
      Tropomyosin_1; Tropomyosin like

    Alternate CHM1_1.1

    Genomic

    1. NC_018926.2 Alternate CHM1_1.1

      Range
      63453982..63483261
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)