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Cttn cortactin [ Mus musculus (house mouse) ]

Gene ID: 13043, updated on 21-Feb-2015
Official Symbol
Cttnprovided by MGI
Official Full Name
cortactinprovided by MGI
Primary source
MGI:MGI:99695
See related
Ensembl:ENSMUSG00000031078; Vega:OTTMUSG00000016455
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ems1; 1110020L01Rik
Orthologs
See Cttn in MapViewer
Location:
7; 7 F5
Exon count:
19
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 7 NC_000073.6 (144435723..144471004, complement)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene SH3/ankyrin domain gene 2 Neighboring gene predicted gene, 34621 Neighboring gene predicted gene, 34561 Neighboring gene protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 Neighboring gene predicted gene, 35626 Neighboring gene Fas (TNFRSF6)-associated via death domain

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Bacterial invasion of epithelial cells, organism-specific biosystem (from KEGG)
    Bacterial invasion of epithelial cells, organism-specific biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
  • Bacterial invasion of epithelial cells, conserved biosystem (from KEGG)
    Bacterial invasion of epithelial cells, conserved biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
  • PodNet: protein-protein interactions in the podocyte, organism-specific biosystem (from WikiPathways)
    PodNet: protein-protein interactions in the podocyte, organism-specific biosystemPodNet is a manually curated network of protein-protein interactions occurring in the podocyte.
  • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
    Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • Proteoglycans in cancer, conserved biosystem (from KEGG)
    Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • Tight junction, organism-specific biosystem (from KEGG)
    Tight junction, organism-specific biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
  • Tight junction, conserved biosystem (from KEGG)
    Tight junction, conserved biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
  • XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
    XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
proline-rich region binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
actin cytoskeleton reorganization ISO
Inferred from Sequence Orthology
more info
 
actin filament polymerization IEA
Inferred from Electronic Annotation
more info
 
cell motility ISO
Inferred from Sequence Orthology
more info
 
dendritic spine maintenance IGI
Inferred from Genetic Interaction
more info
PubMed 
endocytosis IEA
Inferred from Electronic Annotation
more info
 
focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
 
intracellular protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular protein transport ISO
Inferred from Sequence Orthology
more info
 
lamellipodium organization ISO
Inferred from Sequence Orthology
more info
 
negative regulation of extrinsic apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
neuron projection morphogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
 
receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
 
regulation of axon extension ISO
Inferred from Sequence Orthology
more info
 
substrate-dependent cell migration, cell extension IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with actin filament ISO
Inferred from Sequence Orthology
more info
 
cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
cell junction ISO
Inferred from Sequence Orthology
more info
 
cell projection IEA
Inferred from Electronic Annotation
more info
 
coated pit ISO
Inferred from Sequence Orthology
more info
 
cortical cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
extracellular vesicular exosome ISO
Inferred from Sequence Orthology
more info
 
focal adhesion ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with focal adhesion ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with growth cone ISO
Inferred from Sequence Orthology
more info
 
lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
lamellipodium ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
mitotic spindle midzone IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
ruffle IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with voltage-gated potassium channel complex IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
src substrate cortactin
Names
src substrate cortactin
mammary tumor and squamous cell carcinoma associated (p80/85 src substrate)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252572.1NP_001239501.1  src substrate cortactin isoform 2

    See proteins identical to NP_001239501.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AK084249, AK168871, AK168945, BY137811, BY265697, BY760295
    Consensus CDS
    CCDS57599.1
    UniProtKB/TrEMBL
    Q8BNA5
    UniProtKB/TrEMBL
    Q921L6
    Related
    ENSMUSP00000033407, OTTMUSP00000017696, ENSMUST00000033407, OTTMUST00000039646
    Conserved Domains (4) summary
    pfam02218
    Location:157193
    HS1_rep; Repeat in HS1/Cortactin
    cd11959
    Location:455507
    SH3_Cortactin; Src homology 3 domain of Cortactin
    pfam15552
    Location:350423
    DUF4657; Domain of unknown function (DUF4657)
    cl15270
    Location:318379
    FinO_conjug_rep; FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which ...
  2. NM_007803.5NP_031829.2  src substrate cortactin isoform 1

    See proteins identical to NP_031829.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AK168699, BY137811, BY265697, BY760295
    Consensus CDS
    CCDS22049.1
    UniProtKB/Swiss-Prot
    Q60598
    Related
    ENSMUSP00000099368, OTTMUSP00000017695, ENSMUST00000103079, OTTMUST00000039645
    Conserved Domains (4) summary
    pfam02218
    Location:157193
    HS1_rep; Repeat in HS1/Cortactin
    cd11959
    Location:492544
    SH3_Cortactin; Src homology 3 domain of Cortactin
    pfam15552
    Location:387460
    DUF4657; Domain of unknown function (DUF4657)
    cl15270
    Location:355416
    FinO_conjug_rep; FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000073.6 Reference GRCm38.p3 C57BL/6J

    Range
    144435723..144471004
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508473.1XP_006508536.1  

    Conserved Domains (4) summary
    pfam02218
    Location:157193
    HS1_rep; Repeat in HS1/Cortactin
    cd11959
    Location:418470
    SH3_Cortactin; Src homology 3 domain of Cortactin
    pfam07946
    Location:271326
    DUF1682; Protein of unknown function (DUF1682)
    pfam15552
    Location:313386
    DUF4657; Domain of unknown function (DUF4657)
  2. XM_006508475.2XP_006508538.1  

    Conserved Domains (1) summary
    pfam02218
    Location:157193
    HS1_rep; Repeat in HS1/Cortactin
  3. XM_006508474.2XP_006508537.1  

    Conserved Domains (1) summary
    pfam02218
    Location:157193
    HS1_rep; Repeat in HS1/Cortactin
  4. XM_011241978.1XP_011240280.1  

    Conserved Domains (1) summary
    pfam02218
    Location:157193
    HS1_rep; Repeat in HS1/Cortactin

Alternate Mm_Celera

Genomic

  1. AC_000029.1 Alternate Mm_Celera

    Range
    144198389..144233617
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)