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    Pim2 proviral integration site 2 [ Mus musculus (house mouse) ]

    Gene ID: 18715, updated on 5-Jul-2015
    Official Symbol
    Pim2provided by MGI
    Official Full Name
    proviral integration site 2provided by MGI
    Primary source
    MGI:MGI:97587
    See related
    Ensembl:ENSMUSG00000031155; Vega:OTTMUSG00000018000
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pim-2; DXCch3
    Orthologs
    See Pim2 in Epigenomics, MapViewer
    Location:
    X A1.1; X 3.55 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) X NC_000086.7 (7878306..7883432)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (7455432..7460558)

    Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel, Shal-related family, member 1 Neighboring gene OTU domain containing 5 Neighboring gene solute carrier family 35 (UDP-galactose transporter), member A2 Neighboring gene polyglutamine binding protein 1 Neighboring gene translocase of inner mitochondrial membrane 17b

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Acute myeloid leukemia, organism-specific biosystem (from KEGG)
      Acute myeloid leukemia, organism-specific biosystemAcute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation...
    • Acute myeloid leukemia, conserved biosystem (from KEGG)
      Acute myeloid leukemia, conserved biosystemAcute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    apoptotic mitochondrial changes IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein autophosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein stabilization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    serine/threonine-protein kinase pim-2
    NP_613072.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138606.2NP_613072.1  serine/threonine-protein kinase pim-2

      See identical proteins and their annotated locations for NP_613072.1

      Status: VALIDATED

      Source sequence(s)
      BC022727, L41495
      Consensus CDS
      CCDS29976.1
      UniProtKB/Swiss-Prot
      Q62070
      UniProtKB/TrEMBL
      Q8R1Z0
      Related
      ENSMUSP00000140602, ENSMUST00000190448
      Conserved Domains (2) summary
      smart00220
      Location:91345
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:90346
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000086.7 Reference GRCm38.p3 C57BL/6J

      Range
      7878306..7883432
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000042.1 Alternate Mm_Celera

      Range
      3586468..3591566
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)