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    ADIPOQ adiponectin, C1Q and collagen domain containing [ Homo sapiens (human) ]

    Gene ID: 9370, updated on 28-Jun-2015
    Official Symbol
    ADIPOQprovided by HGNC
    Official Full Name
    adiponectin, C1Q and collagen domain containingprovided by HGNC
    Primary source
    HGNC:HGNC:13633
    See related
    Ensembl:ENSG00000181092; HPRD:05671; MIM:605441; Vega:OTTHUMG00000156521
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ACDC; ADPN; APM1; APM-1; GBP28; ACRP30; ADIPQTL1
    Summary
    This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. The encoded protein circulates in the plasma and is involved with metabolic and hormonal processes. Mutations in this gene are associated with adiponectin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Apr 2010]
    Orthologs
    See ADIPOQ in Epigenomics, MapViewer
    Location:
    3q27
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 3 NC_000003.12 (186842668..186858463)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (186560463..186576252)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4A2 Neighboring gene replication factor C (activator 1) 4, 37kDa Neighboring gene uncharacterized LOC102724699 Neighboring gene ADIPOQ antisense RNA 1 Neighboring gene ribosomal protein S20 pseudogene 14 Neighboring gene ribosomal protein L29 pseudogene 9

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Serum level of adiponectin 1
    MedGen: C2675517 OMIM: 612556 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    A genome-wide association study reveals variants in ARL15 that influence adiponectin levels.
    NHGRI GWA Catalog
    A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2.
    NHGRI GWA Catalog
    Clear detection of ADIPOQ locus as the major gene for plasma adiponectin: results of genome-wide association analyses including 4659 European individuals.
    NHGRI GWA Catalog
    Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease.
    NHGRI GWA Catalog
    Genome-wide association study for adiponectin levels in Filipino women identifies CDH13 and a novel uncommon haplotype at KNG1-ADIPOQ.
    NHGRI GWA Catalog
    Genome-wide linkage and association analyses to identify genes influencing adiponectin levels: the GEMS Study.
    NHGRI GWA Catalog
    Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
    NHGRI GWA Catalog
    Novel locus FER is associated with serum HMW adiponectin levels.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat downregulates the expression of adiponectin protein and upregulates the expression of IL-6, IL-8, and MCP-1 proteins in human SGBS preadipocytes PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cytokine activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    hormone activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    identical protein binding TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    sialic acid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    adiponectin-activated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    brown fat cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to cAMP IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to drug ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to epinephrine stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to insulin stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    circadian rhythm IEA
    Inferred from Electronic Annotation
    more info
     
    detection of oxidative stress ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    fatty acid beta-oxidation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    fatty acid oxidation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    generation of precursor metabolites and energy TAS
    Traceable Author Statement
    more info
    PubMed 
    glucose homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    glucose metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    low-density lipoprotein particle clearance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane depolarization IEA
    Inferred from Electronic Annotation
    more info
     
    membrane hyperpolarization IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of DNA biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of I-kappaB kinase/NF-kappaB signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of MAP kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of blood pressure IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of fat cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of gluconeogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    negative regulation of granulocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of heterotypic cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of hormone secretion IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of inflammatory response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    negative regulation of intracellular protein transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of low-density lipoprotein particle receptor biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of macrophage derived foam cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of macrophage differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of metanephric mesenchymal cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of phagocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of platelet-derived growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of platelet-derived growth factor receptor-alpha signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of smooth muscle cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of smooth muscle cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of synaptic transmission IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of tumor necrosis factor production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of tumor necrosis factor-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of I-kappaB kinase/NF-kappaB signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of blood pressure IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cAMP-dependent protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cellular protein metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cholesterol efflux IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of fatty acid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    positive regulation of glucose import ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    positive regulation of glycogen (starch) synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of interleukin-8 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of metanephric glomerular visceral epithelial cell development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of monocyte chemotactic protein-1 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of myeloid cell apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein kinase A signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of renal albumin absorption IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    protein heterotrimerization IEA
    Inferred from Electronic Annotation
    more info
     
    protein homooligomerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein localization to plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of glucose metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to activity IEA
    Inferred from Electronic Annotation
    more info
     
    response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    response to glucocorticoid IEA
    Inferred from Electronic Annotation
    more info
     
    response to glucose ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    response to linoleic acid IEA
    Inferred from Electronic Annotation
    more info
     
    response to nutrient IEA
    Inferred from Electronic Annotation
    more info
     
    response to sucrose IEA
    Inferred from Electronic Annotation
    more info
     
    response to tumor necrosis factor IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    collagen trimer IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    adiponectin
    Names
    adiponectin
    30 kDa adipocyte complement-related protein
    adipocyte complement-related 30 kDa protein
    adipose most abundant gene transcript 1 protein
    adipose specific collagen-like factor
    gelatin-binding protein 28

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021140.1 RefSeqGene

      Range
      5001..20790
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001177800.1NP_001171271.1  adiponectin precursor

      See identical proteins and their annotated locations for NP_001171271.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC072018, AC112907, AK312868
      Consensus CDS
      CCDS3284.1
      UniProtKB/TrEMBL
      A8K660
      UniProtKB/TrEMBL
      B2R773
      UniProtKB/Swiss-Prot
      Q15848
      Related
      ENSP00000389814, OTTHUMP00000210047, ENST00000444204, OTTHUMT00000344489
      Conserved Domains (2) summary
      smart00110
      Location:106242
      C1Q; Complement component C1q domain
      pfam01391
      Location:42106
      Collagen; Collagen triple helix repeat (20 copies)
    2. NM_004797.3NP_004788.1  adiponectin precursor

      See identical proteins and their annotated locations for NP_004788.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC072018, AC112907, AK291525, BC096308
      Consensus CDS
      CCDS3284.1
      UniProtKB/TrEMBL
      A8K660
      UniProtKB/Swiss-Prot
      Q15848
      Related
      ENSP00000320709, OTTHUMP00000210048, ENST00000320741, OTTHUMT00000344490
      Conserved Domains (2) summary
      smart00110
      Location:106242
      C1Q; Complement component C1q domain
      pfam01391
      Location:42106
      Collagen; Collagen triple helix repeat (20 copies)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p2 Primary Assembly

      Range
      186842668..186858463
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011513324.1XP_011511626.1  

      See identical proteins and their annotated locations for XP_011511626.1

      Conserved Domains (2) summary
      smart00110
      Location:106242
      C1Q; Complement component C1q domain
      pfam01391
      Location:42106
      Collagen; Collagen triple helix repeat (20 copies)

    Alternate CHM1_1.1

    Genomic

    1. NC_018914.2 Alternate CHM1_1.1

      Range
      186523992..186539778
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)