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MAP1LC3B microtubule-associated protein 1 light chain 3 beta [ Homo sapiens (human) ]

Gene ID: 81631, updated on 6-Jul-2014
Official Symbol
MAP1LC3Bprovided by HGNC
Official Full Name
microtubule-associated protein 1 light chain 3 betaprovided by HGNC
Primary source
HGNC:13352
See related
Ensembl:ENSG00000140941; HPRD:14358; MIM:609604; Vega:OTTHUMG00000137654
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LC3B; ATG8F; MAP1LC3B-a; MAP1A/1BLC3
Summary
The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are involved in microtubule assembly and important for neurogenesis. Studies on the rat homolog implicate a role for this gene in autophagy, a process that involves the bulk degradation of cytoplasmic component. [provided by RefSeq, Jul 2008]
See MAP1LC3B in Epigenomics, MapViewer
Location:
16q24.2
Exon count :
5
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 16 NC_000016.10 (87389551..87404774)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (87423157..87438380)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928659 Neighboring gene F-box protein 31 Neighboring gene transfer RNA-Met (CAT) 6-1 Neighboring gene zinc finger, CCHC domain containing 14 Neighboring gene nuclear receptor subfamily 3, group C, member 1 pseudogene 1 Neighboring gene junctophilin 3 Neighboring gene uncharacterized LOC100129215

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A mega-analysis of genome-wide association studies for major depressive disorder.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Gag, Pr55 gag Protein/protein interactions of virus/autophagy-associated proteins by yeast two-hybrid array reveals the interaction between HIV-1 Gag and microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) PubMed
Tat, p14 tat HIV-1 Tat suppresses IFN-gamma-induced LC3B protein expression and autophagosome formation through Tat-mediated suppression of STAT1 phosphorylation PubMed
pol gag-pol HIV-1 protease extensively cleaves microtubule-associated proteins 1 and 2 and completely inhibits microtubule assembly PubMed

Go to the HIV-1, Human Protein Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GABA receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
 
phosphatidylethanolamine binding IBA
Inferred from Biological aspect of Ancestor
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
CVT pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
autophagic vacuole assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
cellular response to nitrogen starvation IBA
Inferred from Biological aspect of Ancestor
more info
 
late nucleophagy IBA
Inferred from Biological aspect of Ancestor
more info
 
mitochondrion degradation IBA
Inferred from Biological aspect of Ancestor
more info
 
piecemeal microautophagy of nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
protein targeting to vacuole involved in autophagy IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
autophagic vacuole ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
autophagic vacuole membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
axoneme ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
endomembrane system IEA
Inferred from Electronic Annotation
more info
 
intracellular IDA
Inferred from Direct Assay
more info
 
microtubule IEA
Inferred from Electronic Annotation
more info
 
organelle membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
pre-autophagosomal structure IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
microtubule-associated proteins 1A/1B light chain 3B
Names
microtubule-associated proteins 1A/1B light chain 3B
MAP1A/MAP1B LC3 B
MAP1A/MAP1B light chain 3 B
MAP1 light chain 3-like protein 2
autophagy-related ubiquitin-like modifier LC3 B

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029030.1 

    Range
    5001..17580
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_022818.4NP_073729.1  microtubule-associated proteins 1A/1B light chain 3B

    See proteins identical to NP_073729.1

    Status: REVIEWED

    Source sequence(s)
    AK025556, AL834298, DA577457, DB055844
    Consensus CDS
    CCDS10960.1
    UniProtKB/TrEMBL
    Q658J6
    UniProtKB/Swiss-Prot
    Q9GZQ8
    Related
    ENSP00000268607, OTTHUMP00000175009, ENST00000268607, OTTHUMT00000269106
    Conserved Domains (1) summary
    cd01611
    Location:7120
    Blast Score: 449
    GABARAP; Ubiquitin domain of GABA-receptor-associated protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000016.10 

    Range
    87389551..87404774
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005256184.1XP_005256241.1  

    See proteins identical to XP_005256241.1

    UniProtKB/TrEMBL
    Q658J6
    UniProtKB/Swiss-Prot
    Q9GZQ8
    Conserved Domains (1) summary
    cd01611
    Location:7120
    Blast Score: 449
    GABARAP; Ubiquitin domain of GABA-receptor-associated protein

Alternate HuRef

Genomic

  1. AC_000148.1 

    Range
    73168889..73180793
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018927.2 

    Range
    88837611..88850167
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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