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Ikzf1 IKAROS family zinc finger 1 [ Mus musculus (house mouse) ]

Gene ID: 22778, updated on 11-Sep-2014
Official Symbol
Ikzf1provided by MGI
Official Full Name
IKAROS family zinc finger 1provided by MGI
Primary source
MGI:1342540
Locus tag
RP23-373H2.2
See related
Ensembl:ENSMUSG00000018654; Vega:OTTMUSG00000005161
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LyF-1; hlk-1; Ikaros; Zfpn1a1; Znfn1a1; mKIAA4227; 5832432G11Rik
See Ikzf1 in Epigenomics, MapViewer
Location:
11 A1; 11 7.02 cM
Exon count:
13
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 11 NC_000077.6 (11684969..11772930)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102631662 Neighboring gene uncharacterized LOC102631513 Neighboring gene uncharacterized LOC102631730 Neighboring gene uncharacterized LOC102631840 Neighboring gene uncharacterized LOC102631906 Neighboring gene fidgetin-like 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA4227

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
sequence-specific DNA binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription regulatory region DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Peyer's patch development IMP
Inferred from Mutant Phenotype
more info
PubMed 
T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
chromatin modification IEA
Inferred from Electronic Annotation
more info
 
forebrain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
lymph node development IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organismal development IEA
Inferred from Electronic Annotation
more info
 
natural killer cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of NK T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of multicellular organism growth IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neutrophil differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
retina development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
thymus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
pericentric heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor complex TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
DNA-binding protein Ikaros
Names
DNA-binding protein Ikaros
ikaros family zinc finger protein 1
lymphoid transcription factor LyF-1
zinc finger protein subfamily 1A, 1
zinc finger protein, subfamily 1A, 1 (Ikaros)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025597.1NP_001020768.1  DNA-binding protein Ikaros isoform a

    See proteins identical to NP_001020768.1

    Status: VALIDATED

    Source sequence(s)
    AK077815, AL596450
    Consensus CDS
    CCDS24436.1
    UniProtKB/TrEMBL
    G5E8H3
    UniProtKB/TrEMBL
    Q8C5P6
    Related
    ENSMUSP00000075992, ENSMUST00000076700
    Conserved Domains (2) summary
    COG5048
    Location:144218
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:132156
    zf-H2C2_2; Zinc-finger double domain
  2. NM_009578.2NP_033604.2  DNA-binding protein Ikaros isoform b

    See proteins identical to NP_033604.2

    Status: VALIDATED

    Source sequence(s)
    AK040268, AK077815, AL596450
    Consensus CDS
    CCDS24437.1
    UniProtKB/TrEMBL
    Q5SWU0
    UniProtKB/TrEMBL
    Q8C5P6
    UniProtKB/TrEMBL
    Q8C9X3
    Conserved Domains (2) summary
    COG5048
    Location:1131
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:7297
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000077.6 

    Range
    11684969..11772930
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514669.1XP_006514732.1  

    Conserved Domains (2) summary
    COG5048
    Location:168242
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:156180
    zf-H2C2_2; Zinc-finger double domain
  2. XM_006514672.1XP_006514735.1  

    Conserved Domains (2) summary
    COG5048
    Location:167505
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:156180
    zf-H2C2_2; Zinc-finger double domain
  3. XM_006514679.1XP_006514742.1  

    Conserved Domains (2) summary
    COG5048
    Location:167470
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:156180
    zf-H2C2_2; Zinc-finger double domain
  4. XM_006514678.1XP_006514741.1  

    Conserved Domains (1) summary
    pfam13465
    Location:156180
    zf-H2C2_2; Zinc-finger double domain
  5. XM_006514671.1XP_006514734.1  

    See proteins identical to XP_006514734.1

    Conserved Domains (2) summary
    COG5048
    Location:160234
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:148172
    zf-H2C2_2; Zinc-finger double domain
  6. XM_006514675.1XP_006514738.1  

    See proteins identical to XP_006514738.1

    UniProtKB/TrEMBL
    G5E8H3
    Conserved Domains (2) summary
    COG5048
    Location:144218
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:132156
    zf-H2C2_2; Zinc-finger double domain
  7. XM_006514681.1XP_006514744.1  

    Conserved Domains (2) summary
    COG5048
    Location:168223
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:156180
    zf-H2C2_2; Zinc-finger double domain
  8. XM_006514684.1XP_006514747.1  

    Conserved Domains (2) summary
    COG5048
    Location:25155
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:96121
    zf-H2C2_2; Zinc-finger double domain
  9. XM_006514680.1XP_006514743.1  

    Conserved Domains (2) summary
    COG5048
    Location:110184
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:98122
    zf-H2C2_2; Zinc-finger double domain
  10. XM_006514673.1XP_006514736.1  

    See proteins identical to XP_006514736.1

    UniProtKB/TrEMBL
    G5E8H3
    Conserved Domains (2) summary
    COG5048
    Location:144218
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:132156
    zf-H2C2_2; Zinc-finger double domain
  11. XM_006514682.1XP_006514745.1  

    See proteins identical to XP_006514745.1

    Conserved Domains (2) summary
    COG5048
    Location:25155
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:96121
    zf-H2C2_2; Zinc-finger double domain
  12. XM_006514686.1XP_006514749.1  

    Conserved Domains (3) summary
    COG5048
    Location:25136
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam00096
    Location:82104
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:96121
    zf-H2C2_2; Zinc-finger double domain
  13. XM_006514687.1XP_006514750.1  

    Conserved Domains (3) summary
    COG5048
    Location:25136
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam00096
    Location:82104
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:96121
    zf-H2C2_2; Zinc-finger double domain
  14. XM_006514676.1XP_006514739.1  

    See proteins identical to XP_006514739.1

    UniProtKB/TrEMBL
    G5E8H3
    Conserved Domains (2) summary
    COG5048
    Location:144218
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:132156
    zf-H2C2_2; Zinc-finger double domain
  15. XM_006514670.1XP_006514733.1  

    See proteins identical to XP_006514733.1

    Conserved Domains (2) summary
    COG5048
    Location:160234
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:148172
    zf-H2C2_2; Zinc-finger double domain
  16. XM_006514677.1XP_006514740.1  

    Related
    ENSMUSP00000067372, OTTMUSP00000005365, ENSMUST00000065433, OTTMUST00000011534
    Conserved Domains (2) summary
    COG5048
    Location:143481
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:132156
    zf-H2C2_2; Zinc-finger double domain
  17. XM_006514674.1XP_006514737.1  

    See proteins identical to XP_006514737.1

    UniProtKB/TrEMBL
    G5E8H3
    Conserved Domains (2) summary
    COG5048
    Location:144218
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:132156
    zf-H2C2_2; Zinc-finger double domain
  18. XM_006514685.1XP_006514748.1  

    See proteins identical to XP_006514748.1

    UniProtKB/TrEMBL
    Q5SWU0
    Conserved Domains (2) summary
    COG5048
    Location:1131
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:7297
    zf-H2C2_2; Zinc-finger double domain
  19. XM_006514688.1XP_006514751.1  

    See proteins identical to XP_006514751.1

    UniProtKB/TrEMBL
    Q3UQ33
    Conserved Domains (3) summary
    COG5048
    Location:1112
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam00096
    Location:5880
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:7297
    zf-H2C2_2; Zinc-finger double domain
  20. XM_006514683.1XP_006514746.1  

    Conserved Domains (2) summary
    COG5048
    Location:72146
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:6084
    zf-H2C2_2; Zinc-finger double domain

Alternate Mm_Celera

Genomic

  1. AC_000033.1 

    Range
    12146027..12232163
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)