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    CAMP cathelicidin antimicrobial peptide [ Homo sapiens (human) ]

    Gene ID: 820, updated on 24-Aug-2015
    Official Symbol
    CAMPprovided by HGNC
    Official Full Name
    cathelicidin antimicrobial peptideprovided by HGNC
    Primary source
    HGNC:HGNC:1472
    See related
    Ensembl:ENSG00000164047; HPRD:02722; MIM:600474; Vega:OTTHUMG00000133526
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LL37; CAP18; CRAMP; HSD26; CAP-18; FALL39; FALL-39
    Summary
    This gene encodes a member of an antimicrobial peptide family, characterized by a highly conserved N-terminal signal peptide containing a cathelin domain and a structurally variable cationic antimicrobial peptide, which is produced by extracellular proteolysis from the C-terminus. In addition to its antibacterial, antifungal, and antiviral activities, the encoded protein functions in cell chemotaxis, immune mediator induction, and inflammatory response regulation. [provided by RefSeq, Sep 2014]
    Orthologs
    See CAMP in Epigenomics, MapViewer
    Location:
    3p21.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 3 NC_000003.12 (48223347..48225491)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (48264837..48266981)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene cell division cycle 25A Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1 pseudogene 1 Neighboring gene microRNA 4443 Neighboring gene zinc finger protein 589 Neighboring gene mitochondrial ribosomal protein S18A pseudogene 1 Neighboring gene uncharacterized LOC105377076

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of cathelicidin antimicrobial peptide (CAMP) in peptide-treated PBMCs PubMed

    Go to the HIV-1, Human Interaction Database

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    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    antibacterial humoral response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    defense response to Gram-positive bacterium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    defense response to bacterium TAS
    Traceable Author Statement
    more info
    PubMed 
    innate immune response in mucosa IDA
    Inferred from Direct Assay
    more info
    PubMed 
    interaction with host TAS
    Traceable Author Statement
    more info
     
    killing by host of symbiont cells IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of growth of symbiont on or near host surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phagosome maturation TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cell wall TAS
    Traceable Author Statement
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    cathelicidin antimicrobial peptide
    Names
    18 kDa cationic antimicrobial protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004345.4NP_004336.3  cathelicidin antimicrobial peptide preproprotein

      See identical proteins and their annotated locations for NP_004336.3

      Status: REVIEWED

      Source sequence(s)
      AA635187, BC055089, BU074012
      Consensus CDS
      CCDS2762.2
      UniProtKB/TrEMBL
      J3KNB4
      UniProtKB/Swiss-Prot
      P49913
      Related
      ENSP00000296435, OTTHUMP00000164805, ENST00000296435, OTTHUMT00000257501
      Conserved Domains (2) summary
      pfam00666
      Location:35101
      Cathelicidins; Cathelicidin
      pfam12153
      Location:139166
      CAP18_C; LPS binding domain of CAP18 (C terminal)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p2 Primary Assembly

      Range
      48223347..48225491
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018914.2 Alternate CHM1_1.1

      Range
      48217141..48219285
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)