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    Slc9a3r1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 [ Mus musculus (house mouse) ]

    Gene ID: 26941, updated on 5-Jul-2015
    Official Symbol
    Slc9a3r1provided by MGI
    Official Full Name
    solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1provided by MGI
    Primary source
    MGI:MGI:1349482
    See related
    Ensembl:ENSMUSG00000020733; Vega:OTTMUSG00000003641
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EBP-50; NHE-RF; NHERF1; NHERF-1
    Orthologs
    See Slc9a3r1 in Epigenomics, MapViewer
    Location:
    11; 11 E2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 11 NC_000077.6 (115163312..115181183)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (115024655..115042492)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene CD300e antigen Neighboring gene RAB37, member RAS oncogene family Neighboring gene CD300 antigen like family member F Neighboring gene transmembrane protein 104 Neighboring gene N-acetyltransferase 9 (GCN5-related, putative) Neighboring gene glutamate receptor, ionotropic, NMDA2C (epsilon 3)

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC95776

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    beta-2 adrenergic receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
     
    chloride channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    dopamine receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex scaffold ISO
    Inferred from Sequence Orthology
    more info
     
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein self-association ISO
    Inferred from Sequence Orthology
    more info
     
    receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    adenylate cyclase-activating dopamine receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    auditory receptor cell stereocilium organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    bile acid secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cAMP-mediated signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cAMP-mediated signaling ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    cellular phosphate ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment of Golgi localization ISO
    Inferred from Sequence Orthology
    more info
     
    establishment of epithelial cell apical/basal polarity ISO
    Inferred from Sequence Orthology
    more info
     
    establishment of nucleus localization ISO
    Inferred from Sequence Orthology
    more info
     
    establishment of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    gland morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    glutathione transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    microvillus assembly ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of catenin import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of cell motility IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of phosphatidylinositol 3-kinase signaling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of phosphatidylinositol 3-kinase signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of platelet-derived growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein kinase B signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of sodium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of sodium:proton antiporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phospholipase C-activating dopamine receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell size ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of excretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    renal absorption IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    renal phosphate ion absorption ISO
    Inferred from Sequence Orthology
    more info
     
    renal sodium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    apical part of cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    brush border membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell periphery ISO
    Inferred from Sequence Orthology
    more info
     
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    microvillus ISO
    Inferred from Sequence Orthology
    more info
     
    microvillus membrane ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    sperm midpiece IDA
    Inferred from Direct Assay
    more info
    PubMed 
    stereocilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    stereocilium bundle tip IDA
    Inferred from Direct Assay
    more info
    PubMed 
    vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    Na(+)/H(+) exchange regulatory cofactor NHE-RF1
    Names
    EBP50
    ezrin-radixin-moesin-binding phosphoprotein 50
    regulatory cofactor of Na(+)/H(+) exchanger
    sodium-hydrogen exchanger regulatory factor 1
    solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 1
    solute carrier family 9 isoform A3 regulatory factor 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012030.2NP_036160.1  Na(+)/H(+) exchange regulatory cofactor NHE-RF1

      See identical proteins and their annotated locations for NP_036160.1

      Status: VALIDATED

      Source sequence(s)
      AK153558, BB660628
      Consensus CDS
      CCDS36370.1
      UniProtKB/Swiss-Prot
      P70441
      UniProtKB/TrEMBL
      Q3TG37
      Related
      ENSMUSP00000021077, OTTMUSP00000003814, ENSMUST00000021077, OTTMUST00000007862
      Conserved Domains (2) summary
      cd00992
      Location:1291
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09007
      Location:317355
      EBP50_C-term; EBP50, C-terminal

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p3 C57BL/6J

      Range
      115163312..115181183
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533443.1XP_006533506.1  

      Conserved Domains (1) summary
      cd00992
      Location:1291
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    Alternate Mm_Celera

    Genomic

    1. AC_000033.1 Alternate Mm_Celera

      Range
      126928560..126946416
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)