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Bcl11b B cell leukemia/lymphoma 11B [ Mus musculus (house mouse) ]

Gene ID: 58208, updated on 4-May-2015
Official Symbol
Bcl11bprovided by MGI
Official Full Name
B cell leukemia/lymphoma 11Bprovided by MGI
Primary source
MGI:MGI:1929913
See related
Ensembl:ENSMUSG00000048251; Vega:OTTMUSG00000019485
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rit1; Ctip2; BCL-11B; AI604821; 9130430L19Rik; B630002E05Rik
Orthologs
See Bcl11b in MapViewer
Location:
12 F1; 12 59.1 cM
Exon count:
7
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 12 NC_000078.6 (107910403..108004139, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (109148613..109241624, complement)

Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930465M20 gene Neighboring gene predicted gene, 33341 Neighboring gene SET domain containing 3 Neighboring gene predicted gene, 40570 Neighboring gene cyclin K

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
T cell differentiation in thymus IMP
Inferred from Mutant Phenotype
more info
PubMed 
T cell receptor V(D)J recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
alpha-beta T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
central nervous system neuron differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
commitment of neuronal cell to specific neuron type in forebrain IGI
Inferred from Genetic Interaction
more info
PubMed 
epithelial cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
keratinocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
odontogenesis of dentin-containing tooth IMP
Inferred from Mutant Phenotype
more info
PubMed 
olfactory bulb axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive T cell selection IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
post-embryonic camera-type eye development IMP
Inferred from Mutant Phenotype
more info
PubMed 
post-embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of keratinocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
skin development IMP
Inferred from Mutant Phenotype
more info
PubMed 
striatal medium spiny neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
thymus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
intracellular IDA
Inferred from Direct Assay
more info
PubMed 
neuron part IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
B-cell lymphoma/leukemia 11B
Names
B-cell lymphoma/leukemia 11B
B-cell CLL/lymphoma 11B
B-cell leukemia/lymphoma 11B
B-cell lymphoma/leukaemia 11B
COUP-TF interacting protein 2
COUP-TF-interacting protein 2
mRit1
radiation-induced tumor suppressor gene 1 protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079883.1NP_001073352.1  B-cell lymphoma/leukemia 11B isoform a

    See identical proteins and their annotated locations for NP_001073352.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC119219, AC119921, BM950501, BQ442983, CV563304
    Consensus CDS
    CCDS36553.1
    UniProtKB/Swiss-Prot
    Q99PV8
    Related
    ENSMUSP00000068258, OTTMUSP00000021002, ENSMUST00000066060, OTTMUST00000046516
    Conserved Domains (2) summary
    pfam00096
    Location:787808
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:800825
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001286343.1NP_001273272.1  B-cell lymphoma/leukemia 11B isoform c

    See identical proteins and their annotated locations for NP_001273272.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two internal coding exons but maintains the reading frame, compared to variant 1. The resulting isoform (c) lacks an internal segment, compared to isoform a.
    Source sequence(s)
    AC119219, AC119921
    Consensus CDS
    CCDS70419.1
    UniProtKB/Swiss-Prot
    Q99PV8
    Conserved Domains (2) summary
    pfam00096
    Location:593614
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:606631
    zf-H2C2_2; Zinc-finger double domain
  3. NM_021399.2NP_067374.2  B-cell lymphoma/leukemia 11B isoform b

    See identical proteins and their annotated locations for NP_067374.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame coding exon, compared to variant 1. The resulting isoform (b) lacks an internal segment, compared to isoform a.
    Source sequence(s)
    AC119219, AC119921, BQ745012, CV563304
    Consensus CDS
    CCDS36552.1
    UniProtKB/Swiss-Prot
    Q99PV8
    Conserved Domains (2) summary
    pfam00096
    Location:715736
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:728753
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000078.6 Reference GRCm38.p3 C57BL/6J

    Range
    107910403..108004139
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011244153.1XP_011242455.1  

    Conserved Domains (4) summary
    pfam13465
    Location:799824
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:786863
    ZF_C2H2; Zinc finger, C2H2 type
    sd00018
    Location:786808
    ZF_C2H2; Zinc finger, C2H2 type
    sd00019
    Location:427475
    ZF_C2H2; Zinc finger, C2H2 type
  2. XM_006516111.2XP_006516174.1  

    Conserved Domains (2) summary
    pfam00096
    Location:783804
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:796821
    zf-H2C2_2; Zinc-finger double domain
  3. XM_006516114.2XP_006516177.1  

    Conserved Domains (2) summary
    pfam00096
    Location:714735
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:727752
    zf-H2C2_2; Zinc-finger double domain
  4. XM_006516110.2XP_006516173.1  

    Conserved Domains (2) summary
    pfam00096
    Location:827848
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:840865
    zf-H2C2_2; Zinc-finger double domain
  5. XM_011244152.1XP_011242454.1  

    Conserved Domains (4) summary
    pfam13465
    Location:844869
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:831908
    ZF_C2H2; Zinc finger, C2H2 type
    sd00018
    Location:831853
    ZF_C2H2; Zinc finger, C2H2 type
    sd00019
    Location:472520
    ZF_C2H2; Zinc finger, C2H2 type
  6. XM_006516113.2XP_006516176.1  

    Conserved Domains (2) summary
    pfam00096
    Location:759780
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:772797
    zf-H2C2_2; Zinc-finger double domain
  7. XM_006516116.1XP_006516179.1  

    Conserved Domains (3) summary
    pfam00096
    Location:607628
    zf-C2H2; Zinc finger, C2H2 type
    pfam12756
    Location:607685
    zf-C2H2_2; C2H2 type zinc-finger (2 copies)
    pfam13465
    Location:620645
    zf-H2C2_2; Zinc-finger double domain
  8. XM_006516115.1XP_006516178.1  

    Conserved Domains (2) summary
    pfam00096
    Location:656677
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:669694
    zf-H2C2_2; Zinc-finger double domain

Alternate Mm_Celera

Genomic

  1. AC_000034.1 Alternate Mm_Celera

    Range
    109151974..109245238
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)