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Parp Poly-(ADP-ribose) polymerase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 3355109, updated on 18-Jul-2014
Official Symbol
Parpprovided by FlyBase
Official Full Name
Poly-(ADP-ribose) polymeraseprovided by FlyBase
Primary source
FLYBASE:FBgn0010247
Locus tag
Dmel_CG40411
Gene type
protein coding
RNA name
Poly-(ADP-ribose) polymerase
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BEST:LD21673; CG17685; CG17696; CG17718; CG40411; D.PARP; Dm.pARTa; Dmel\CG40411; dmparp; dPARP; LD21673.3prime; parp; PARP; PARP-1; Parp1; PARP1
See Parp in MapViewer
Location:
81F-81F
Exon count:
6
Annotation release Status Assembly Chr Location
Build 5.57 current Release 5 (GCF_000001215.2) 3RHet NW_001848858.1 (1935206..2026815)

NW_001848858.1Genomic Context describing neighboring genes Neighboring gene CG40451 gene product from transcript CG40451-RA Neighboring gene Apoptosis-linked gene-2 Neighboring gene spookier Neighboring gene CG42617 gene product from transcript CG42617-RA

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Homology

  • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
NAD binding IEA
Inferred from Electronic Annotation
more info
 
NAD+ ADP-ribosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
NAD+ ADP-ribosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
histone binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Cajal body organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
chromosome organization TAS
Traceable Author Statement
more info
PubMed 
heat shock-mediated polytene chromosome puffing IEP
Inferred from Expression Pattern
more info
PubMed 
heat shock-mediated polytene chromosome puffing IMP
Inferred from Mutant Phenotype
more info
PubMed 
innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
maintenance of protein location in nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
metamorphosis TAS
Traceable Author Statement
more info
PubMed 
neuron projection morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleolus organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
polytene chromosome puffing TAS
Traceable Author Statement
more info
PubMed 
positive regulation of antibacterial peptide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein ADP-ribosylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein ADP-ribosylation NAS
Non-traceable Author Statement
more info
 
protein ADP-ribosylation TAS
Traceable Author Statement
more info
PubMed 
rRNA transcription TAS
Traceable Author Statement
more info
PubMed 
regulation of RNA splicing IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Cajal body IDA
Inferred from Direct Assay
more info
PubMed 
chromosome IDA
Inferred from Direct Assay
more info
PubMed 
histone locus body IDA
Inferred from Direct Assay
more info
PubMed 
nuclear euchromatin IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus TAS
Traceable Author Statement
more info
PubMed 
nucleus NAS
Non-traceable Author Statement
more info
 
polytene chromosome IDA
Inferred from Direct Assay
more info
PubMed 
polytene chromosome TAS
Traceable Author Statement
more info
PubMed 
polytene chromosome puff IDA
Inferred from Direct Assay
more info
PubMed 
polytene chromosome puff TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
CG40411 gene product from transcript CG40411-RB
Names
CG40411-PB
Parp-PB
Poly(ADP ribose) polymerase 1
Poly(ADP)-Ribose polymerase
Poly(ADP-)Ribose polymerase
Poly(ADP-ribose) polymerase
Poly(ADP-ribose) polymerase 1
Poly-(ADP-ribose) polymerase
NP_001104452.1

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NW_001848858.1 

    Range
    1935206..2026815
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001110982.3NP_001104452.1  Poly-(ADP-ribose) polymerase [Drosophila melanogaster]

    See proteins identical to NP_001104452.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P35875
    Conserved Domains (6) summary
    cd08001
    Location:526629
    Blast Score: 432
    WGR_PARP1_like; WGR domain of poly(ADP-ribose) polymerase 1 and similar proteins
    PLN03123
    Location:6992
    Blast Score: 1723
    PLN03123; poly [ADP-ribose] polymerase; Provisional
    cd00027
    Location:387454
    Blast Score: 99
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
    cd01437
    Location:645988
    Blast Score: 1358
    parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
    pfam00645
    Location:114197
    Blast Score: 281
    zf-PARP; Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
    pfam08063
    Location:269321
    Blast Score: 174
    PADR1; PADR1 (NUC008) domain