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STARD13 StAR-related lipid transfer (START) domain containing 13 [ Homo sapiens (human) ]

Gene ID: 90627, updated on 5-Apr-2015
Official Symbol
STARD13provided by HGNC
Official Full Name
StAR-related lipid transfer (START) domain containing 13provided by HGNC
Primary source
HGNC:HGNC:19164
See related
Ensembl:ENSG00000133121; HPRD:11607; MIM:609866; Vega:OTTHUMG00000016708
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DLC2; GT650; ARHGAP37; LINC00464
Summary
This gene encodes a protein which contains an N-terminal sterile alpha motif (SAM) for protein-protein interactions, followed by an ATP/GTP-binding motif, a GTPase-activating protein (GAP) domain, and a C-terminal STAR-related lipid transfer (START) domain. It may be involved in regulation of cytoskeletal reorganization, cell proliferation, and cell motility, and acts as a tumor suppressor in hepatoma cells. The gene is located in a region of chromosome 13 that is associated with loss of heterozygosity in hepatocellular carcinomas. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Orthologs
See STARD13 in MapViewer
Location:
13q13.1
Exon count:
25
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 13 NC_000013.11 (33103135..33676835, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (33677272..34250932, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene TOMM22 pseudogene 3 Neighboring gene uncharacterized LOC101927403 Neighboring gene klotho Neighboring gene uncharacterized LOC105370155 Neighboring gene STARD13 antisense RNA Neighboring gene uncharacterized LOC105370154 Neighboring gene uncharacterized LOC105370153 Neighboring gene uncharacterized LOC102723406 Neighboring gene uncharacterized LOC105370157 Neighboring gene RNA, U5A small nuclear 4, pseudogene Neighboring gene replication factor C (activator 1) 3, 38kDa

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
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NHGRI GWA Catalog
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NHGRI GWA Catalog
Genome-wide association study of body mass index in 23 000 individuals with and without asthma.
NHGRI GWA Catalog
Genome-wide association study of intracranial aneurysm identifies three new risk loci.
NHGRI GWA Catalog
  • Rho GTPase cycle, organism-specific biosystem (from REACTOME)
    Rho GTPase cycle, organism-specific biosystemThe cycling of Rho GTPases is tightly controlled by three classes of protein. These are (1) guanine nucleotide dissociation inhibitors or GDIs, which maintain Rho proteins in an inactive state in the...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ37385

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
lipid binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
lipid particle IEA
Inferred from Electronic Annotation
more info
 
mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
stAR-related lipid transfer protein 13
Names
stAR-related lipid transfer protein 13
Rho GTPase activating protein on chromosome 13q12
deleted in liver cancer 2 protein
long intergenic non-protein coding RNA 464

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029752.1 RefSeqGene

    Range
    5001..187630
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001243466.1NP_001230395.1  stAR-related lipid transfer protein 13 isoform 5

    See identical proteins and their annotated locations for NP_001230395.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains an alternate 5' terminal exon, and differs at the 3' end compared to variant 1. This results in a shorter isoform (5) with distinct N- and C- termini compared to isoform 1.
    Source sequence(s)
    AK308453, BC046563
    UniProtKB/Swiss-Prot
    Q9Y3M8
    Conserved Domains (3) summary
    cd09592
    Location:49112
    SAM_DLC2; SAM domain of STARD13-like subfamily
    smart00454
    Location:53112
    SAM; Sterile alpha motif
    cl02570
    Location:649686
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
  2. NM_001243474.1NP_001230403.1  stAR-related lipid transfer protein 13 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) contains an alternate 5' terminal exon, and differs at the 3' end compared to variant 1. This results in translation initiation from an in-frame downstream AUG, and an isoform (6) with a shorter N-terminus, and a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK091804, AK308453, BC046563, BP233049
    UniProtKB/TrEMBL
    B3KRK6
    UniProtKB/Swiss-Prot
    Q9Y3M8
    Conserved Domains (1) summary
    cl02570
    Location:539642
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
  3. NM_001243476.2NP_001230405.1  stAR-related lipid transfer protein 13 isoform 4

    See identical proteins and their annotated locations for NP_001230405.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks a portion of the 5' coding region and contains multiple alternate 5' exons, and initiates initiates translation at an alternate start codon, compared to variant 1. This results in a shorter isoform (4) with a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AA256386, AK308453, AY082589, BX647695, CB163673, DA312208, DB449764
    UniProtKB/Swiss-Prot
    Q9Y3M8
    Conserved Domains (4) summary
    cd08909
    Location:8651069
    START_STARD13-like; C-terminal lipid-binding START domain of mammalian STARD13 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
    cd09592
    Location:2285
    SAM_DLC2; SAM domain of STARD13-like subfamily
    smart00454
    Location:2685
    SAM; Sterile alpha motif
    cd04375
    Location:622839
    RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...
  4. NM_052851.2NP_443083.1  stAR-related lipid transfer protein 13 isoform 3

    See identical proteins and their annotated locations for NP_443083.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal exon compared to variant 1. This results in translation initiation from an in-frame downstream AUG, and an isoform (3, also known as DLC2gamma) with a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AA256386, AL049801, AY082590, AY082591, AY366448, BP233049, CB163673
    Consensus CDS
    CCDS9350.1
    UniProtKB/TrEMBL
    B2R789
    UniProtKB/Swiss-Prot
    Q9Y3M8
    Related
    ENSP00000382300, OTTHUMP00000205446, ENST00000399365, OTTHUMT00000044437
    Conserved Domains (2) summary
    cd08909
    Location:782986
    START_STARD13-like; C-terminal lipid-binding START domain of mammalian STARD13 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
    cd04375
    Location:539756
    RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...
  5. NM_178006.3NP_821074.1  stAR-related lipid transfer protein 13 isoform 1

    See identical proteins and their annotated locations for NP_821074.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1, also known as DLC2alpha).
    Source sequence(s)
    AA256386, AY082589, AY082590, AY366448, CB163673, DC402824
    Consensus CDS
    CCDS9348.1
    UniProtKB/TrEMBL
    A0A024RDV4
    UniProtKB/Swiss-Prot
    Q9Y3M8
    Related
    ENSP00000338785, OTTHUMP00000178559, ENST00000336934, OTTHUMT00000276118
    Conserved Domains (4) summary
    cd08909
    Location:9001104
    START_STARD13-like; C-terminal lipid-binding START domain of mammalian STARD13 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
    cd09592
    Location:57120
    SAM_DLC2; SAM domain of STARD13-like subfamily
    smart00454
    Location:61120
    SAM; Sterile alpha motif
    cd04375
    Location:657874
    RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...
  6. NM_178007.2NP_821075.1  stAR-related lipid transfer protein 13 isoform 2

    See identical proteins and their annotated locations for NP_821075.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon compared to variant 1. This results in a shorter isoform (2, also known as DLC2beta) with a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AA256386, AY082590, AY366448, CB163673
    Consensus CDS
    CCDS9349.1
    UniProtKB/Swiss-Prot
    Q9Y3M8
    Related
    ENSP00000255486, OTTHUMP00000178560, ENST00000255486, OTTHUMT00000044439
    Conserved Domains (4) summary
    cd08909
    Location:8921096
    START_STARD13-like; C-terminal lipid-binding START domain of mammalian STARD13 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
    cd09592
    Location:49112
    SAM_DLC2; SAM domain of STARD13-like subfamily
    smart00454
    Location:53112
    SAM; Sterile alpha motif
    cd04375
    Location:649866
    RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p2 Primary Assembly

    Range
    33103135..33676835
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011535299.1XP_011533601.1  

    See identical proteins and their annotated locations for XP_011533601.1

    Conserved Domains (4) summary
    cd08909
    Location:8651069
    START_STARD13-like; C-terminal lipid-binding START domain of mammalian STARD13 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
    cd09592
    Location:2285
    SAM_DLC2; SAM domain of STARD13-like subfamily
    smart00454
    Location:2685
    SAM; Sterile alpha motif
    cd04375
    Location:622839
    RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...
  2. XM_011535298.1XP_011533600.1  

    Conserved Domains (4) summary
    cd08909
    Location:9111115
    START_STARD13-like; C-terminal lipid-binding START domain of mammalian STARD13 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
    cd09592
    Location:68131
    SAM_DLC2; SAM domain of STARD13-like subfamily
    smart00454
    Location:72131
    SAM; Sterile alpha motif
    cd04375
    Location:668885
    RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...

Alternate CHM1_1.1

Genomic

  1. NC_018924.2 Alternate CHM1_1.1

    Range
    33644794..34218922
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_178008.1: Suppressed sequence

    Description
    NM_178008.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.