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    Sirt1 sirtuin 1 [ Mus musculus (house mouse) ]

    Gene ID: 93759, updated on 9-Feb-2016
    Official Symbol
    Sirt1provided by MGI
    Official Full Name
    sirtuin 1provided by MGI
    Primary source
    MGI:MGI:2135607
    See related
    Ensembl:ENSMUSG00000020063; Vega:OTTMUSG00000030914
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sir2; Sir2a; SIR2L1; AA673258; Sir2alpha
    Summary
    This gene encodes a member of the sirtuin family of proteins, characterized by their deacetylase activity and proposed role in longevity. The encoded protein regulates gene expression in a wide range of cell and tissue types through its NAD+-dependent deacetylation of histones, transcription factors and transcriptional coactivators. Brain-specific overexpression of this gene has been shown to result in increased median lifespan. Viability of homozygous knockout mice for this gene varies with strain background. Homozygous knockout mice of strains that do not exhibit embryonic lethality are sterile and have a reduced lifespan. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
    Orthologs
    See Sirt1 in Epigenomics, MapViewer
    Location:
    10; 10 B4
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 10 NC_000076.6 (63319005..63339061, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (62781753..62801783, complement)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene myopalladin Neighboring gene hect domain and RLD 4 Neighboring gene DnaJ heat shock protein family (Hsp40) member C12 Neighboring gene calcyclin binding protein pseudogene

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC150273

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    (3,5-dichlorophenylurea)acetate amidohydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    HLH domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    N-acetylcitrulline deacetylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    N-acetylgalactosamine-6-phosphate deacetylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    N-cyclohexylformamide amidohydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    N-isopropylacetanilide amidohydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    N2-acetyl-L-lysine deacetylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    NAD+ binding IEA
    Inferred from Electronic Annotation
    more info
     
    NAD-dependent histone deacetylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NAD-dependent histone deacetylase activity ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    NAD-dependent histone deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    NAD-dependent histone deacetylase activity (H3-K9 specific) IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NAD-dependent protein deacetylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NAD-dependent protein deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    O-succinylbenzoate synthase activity IEA
    Inferred from Electronic Annotation
    more info
     
    UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    bHLH transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    chitooligosaccharide deacetylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    cis-aconitamide amidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    core promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    deacetylase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    diacetylchitobiose deacetylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    didemethylisoproturon amidohydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    gamma-N-formylaminovinylacetate hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    histone deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    indoleacetamide hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    iprodione amidohydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    isonicotinic acid hydrazide hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    keratin filament binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    mitogen-activated protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    p53 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    p53 binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein deacetylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein deacetylase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase B binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein-N-terminal asparagine amidohydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transcription corepressor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    DNA synthesis involved in DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    UV-damage excision repair ISO
    Inferred from Sequence Orthology
    more info
     
    angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    behavioral response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cellular glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to ionizing radiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
     
    cellular triglyceride homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cholesterol homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chromatin organization ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin silencing at rDNA ISO
    Inferred from Sequence Orthology
    more info
     
    circadian regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    circadian regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    establishment of chromatin silencing ISO
    Inferred from Sequence Orthology
    more info
     
    fatty acid homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    histone H3 deacetylation ISO
    Inferred from Sequence Orthology
    more info
     
    histone deacetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone deacetylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    histone deacetylation ISO
    Inferred from Sequence Orthology
    more info
     
    intrinsic apoptotic signaling pathway in response to DNA damage IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    leptin-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    maintenance of chromatin silencing ISO
    Inferred from Sequence Orthology
    more info
     
    multicellular organismal development IEA
    Inferred from Electronic Annotation
    more info
     
    muscle organ development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of DNA damage response, signal transduction by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of TOR signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of androgen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cAMP-dependent protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cardiac muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell death ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cellular response to testosterone stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cellular senescence ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of fibroblast apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of growth hormone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of histone H3-K14 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of histone H4-K16 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron death IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of peptidyl-lysine acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of prostaglandin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein kinase B signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of reactive oxygen species biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of sequence-specific DNA binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of sequence-specific DNA binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    ovulation from ovarian follicle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptidyl-lysine acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-lysine deacetylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of MHC class II biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of adaptive immune response ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cAMP-dependent protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cAMP-dependent protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cellular senescence ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cholesterol efflux IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of chromatin silencing ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gluconeogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of heart rate ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of histone H3-K9 methylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of macroautophagy IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of macroautophagy ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of macrophage apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of phosphatidylinositol 3-kinase signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein deacetylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of skeletal muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of thyroid-stimulating hormone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of vasodilation ISO
    Inferred from Sequence Orthology
    more info
     
    proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    protein deacetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein deacetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein deacetylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein destabilization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein destabilization ISO
    Inferred from Sequence Orthology
    more info
     
    protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    pyrimidine dimer repair by nucleotide-excision repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    pyrimidine dimer repair by nucleotide-excision repair ISO
    Inferred from Sequence Orthology
    more info
     
    rRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of bile acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of brown fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of endodeoxyribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of energy homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of glucose metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of peroxisome proliferator activated receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of protein import into nucleus, translocation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of smooth muscle cell apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    response to ethanol ISO
    Inferred from Sequence Orthology
    more info
     
    response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    response to insulin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to leptin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    single strand break repair ISO
    Inferred from Sequence Orthology
    more info
     
    spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    stress-induced premature senescence ISO
    Inferred from Sequence Orthology
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    triglyceride mobilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    white fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    colocalizes_with ESC/E(Z) complex ISO
    Inferred from Sequence Orthology
    more info
     
    PML body ISO
    Inferred from Sequence Orthology
    more info
     
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin silencing complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear euchromatin ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear heterochromatin ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    rDNA heterochromatin ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    NAD-dependent protein deacetylase sirtuin-1
    Names
    SIR2-like protein 1
    regulatory protein SIR2 homolog 1
    sirtuin 1 ((silent mating type information regulation 2, homolog) 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159589.2NP_001153061.1  NAD-dependent protein deacetylase sirtuin-1 isoform 2

      See identical proteins and their annotated locations for NP_001153061.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC153516, AK139946, AK140330, AK141245, BE989110, BX523319
      Consensus CDS
      CCDS48585.1
      UniProtKB/TrEMBL
      Q3UNI1
      UniProtKB/TrEMBL
      Q3USJ2
      UniProtKB/TrEMBL
      Q3USY7
      Related
      ENSMUSP00000101082, OTTMUSP00000040278, ENSMUST00000105442, OTTMUST00000076494
      Conserved Domains (1) summary
      cd01408
      Location:207442
      SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...
    2. NM_019812.3NP_062786.1  NAD-dependent protein deacetylase sirtuin-1 isoform 1

      See identical proteins and their annotated locations for NP_062786.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC153516, AK139946, AK140330, AK141245, BE989110, BX523319
      Consensus CDS
      CCDS23898.1
      UniProtKB/TrEMBL
      Q3USJ2
      UniProtKB/TrEMBL
      Q3USY7
      UniProtKB/TrEMBL
      Q53Z05
      UniProtKB/Swiss-Prot
      Q923E4
      Related
      ENSMUSP00000020257, ENSMUST00000020257
      Conserved Domains (1) summary
      cd01408
      Location:246481
      SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p3 C57BL/6J

      Range
      63319005..63339061 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514342.1XP_006514405.1  

      Conserved Domains (1) summary
      cl00195
      Location:12186
      SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
    2. XM_011243606.1XP_011241908.1  

      Conserved Domains (1) summary
      cl00195
      Location:1194
      SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
    3. XM_006514343.2XP_006514406.1  

      Conserved Domains (1) summary
      cl00195
      Location:246306
      SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

    Alternate Mm_Celera

    Genomic

    1. AC_000032.1 Alternate Mm_Celera

      Range
      64419012..64437105 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001159590.1: Suppressed sequence

      Description
      NM_001159590.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.