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Mstn myostatin [ Mus musculus (house mouse) ]

Gene ID: 17700, updated on 6-Jul-2014
Official Symbol
Mstnprovided by MGI
Official Full Name
myostatinprovided by MGI
Primary source
MGI:95691
See related
Ensembl:ENSMUSG00000026100
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cmpt; Gdf8
See Mstn in Epigenomics, MapViewer
Location:
1 C1.1; 1 26.99 cM
Exon count :
3
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 1 NC_000067.6 (53061663..53068079)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene 3-hydroxyisobutyryl-Coenzyme A hydrolase Neighboring gene heat shock protein 90, alpha (cytosolic), class A member 1 pseudogene Neighboring gene RIKEN cDNA 1700019D03 gene Neighboring gene RIKEN cDNA 1700019A02 gene Neighboring gene postmeiotic segregation increased 1 (S. cerevisiae)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
cytokine activity IEA
Inferred from Electronic Annotation
more info
 
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
heparin binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cellular response to dexamethasone stimulus IDA
Inferred from Direct Assay
more info
 
growth IEA
Inferred from Electronic Annotation
more info
 
negative regulation of muscle hypertrophy ISO
Inferred from Sequence Orthology
more info
 
negative regulation of skeletal muscle tissue growth ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
growth/differentiation factor 8
Names
growth/differentiation factor 8
GDF-8
compact
growth differentiation factor 8

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010834.2NP_034964.1  growth/differentiation factor 8 precursor

    See proteins identical to NP_034964.1

    Status: PROVISIONAL

    Source sequence(s)
    AC129337
    Consensus CDS
    CCDS14950.1
    UniProtKB/Swiss-Prot
    O08689
    UniProtKB/TrEMBL
    Q540E2
    Related
    ENSMUSP00000027269, ENSMUST00000027269
    Conserved Domains (2) summary
    smart00204
    Location:282376
    Blast Score: 377
    TGFB; Transforming growth factor-beta (TGF-beta) family
    pfam00688
    Location:34257
    Blast Score: 464
    TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000067.6 

    Range
    53061663..53068079
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000023.1 

    Range
    53601512..53607928
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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