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Sirpa signal-regulatory protein alpha [ Mus musculus (house mouse) ]

Gene ID: 19261, updated on 19-Sep-2014
Official Symbol
Sirpaprovided by MGI
Official Full Name
signal-regulatory protein alphaprovided by MGI
Primary source
MGI:MGI:108563
Locus tag
RP23-37B4.2
See related
Ensembl:ENSMUSG00000037902; Vega:OTTMUSG00000015506
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bit; P84; SIRP; SHP-1; CD172a; Ptpns1; SHPS-1; AI835480
See Sirpa in Epigenomics, MapViewer
Location:
2 F3; 2 63.19 cM
Exon count:
10
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 2 NC_000068.7 (129592569..129632228)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA F830045P16 gene Neighboring gene uncharacterized LOC102631833 Neighboring gene uncharacterized LOC102631901 Neighboring gene prodynorphin Neighboring gene peptidylprolyl isomerase A (Ppia) pseudogene 2_1620.1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphorylated amino acid binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
actin filament organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell migration ISO
Inferred from Sequence Orthology
more info
 
cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular component movement IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
hematopoietic progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
 
phagocytosis, engulfment IDA
Inferred from Direct Assay
more info
PubMed 
phagocytosis, recognition IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of phagocytosis IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
extracellular vesicular exosome ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
tyrosine-protein phosphatase non-receptor type substrate 1
Names
tyrosine-protein phosphatase non-receptor type substrate 1
mSIRP-alpha1
sirp-alpha-1
myD-1 antigen
SHP substrate 1
inhibitory receptor SHPS-1
signal-regulatory protein alpha-1
CD172 antigen-like family member A
brain immunological-like with tyrosine-based motifs
protein tyrosine phosphatase, non-receptor type substrate 1
brain Ig-like molecule with tyrosine-based activation motifs
NP_001171117.1
NP_001171118.1
NP_031573.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177647.2NP_001171118.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 2 precursor

    See proteins identical to NP_001171118.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons in the central coding region, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 4. The encoded isoform (2) is shorter than isoform 3.
    Source sequence(s)
    AF072544, AK159617, BM899883, CD578948
    Consensus CDS
    CCDS50708.1
    UniProtKB/Swiss-Prot
    P97797
    Conserved Domains (2) summary
    cd00099
    Location:43145
    IgV; Immunoglobulin variable domain (IgV)
    smart00410
    Location:41145
    IG_like; Immunoglobulin like
  2. NM_001291019.1NP_001277948.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 3 precursor

    See proteins identical to NP_001277948.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (3). Both variants 4 and 5 encode isoform 3.
    Source sequence(s)
    AB018194, AK159617, BM899883, CD578948
    Consensus CDS
    CCDS71142.1
    UniProtKB/TrEMBL
    E0CYM8
    UniProtKB/Swiss-Prot
    P97797
    Conserved Domains (4) summary
    cd00098
    Location:257336
    IgC; Immunoglobulin Constant domain
    cd00099
    Location:43145
    IgV; Immunoglobulin variable domain (IgV)
    smart00410
    Location:41145
    IG_like; Immunoglobulin like
    cl11960
    Location:145255
    Ig; Immunoglobulin domain
  3. NM_001291020.1NP_001277949.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 3 precursor

    See proteins identical to NP_001277949.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 4. Both variants 4 and 5 encode isoform 3.
    Source sequence(s)
    AB018194, AK159617, BM899883
    Consensus CDS
    CCDS71142.1
    UniProtKB/TrEMBL
    E0CYM8
    UniProtKB/Swiss-Prot
    P97797
    Conserved Domains (4) summary
    cd00098
    Location:257336
    IgC; Immunoglobulin Constant domain
    cd00099
    Location:43145
    IgV; Immunoglobulin variable domain (IgV)
    smart00410
    Location:41145
    IG_like; Immunoglobulin like
    cl11960
    Location:145255
    Ig; Immunoglobulin domain
  4. NM_001291021.1NP_001277950.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 4 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks two alternate in-frame exons in the central coding region, compared to variant 4, resulting in an isoform (4) that is shorter than isoform 3.
    Source sequence(s)
    AK159617, BM899883, CD578948, CX236057
    Consensus CDS
    CCDS71143.1
    UniProtKB/TrEMBL
    E9QPT7
    Conserved Domains (2) summary
    cd00099
    Location:43145
    IgV; Immunoglobulin variable domain (IgV)
    smart00410
    Location:41145
    IG_like; Immunoglobulin like
  5. NM_001291022.1NP_001277951.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 5 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks an alternate in-frame exon in the 5' coding region and two in-frame exons in the central coding region, and also uses an alternate in-frame splice site in the 3' coding region, compared to variant 4. The encoded isoform (5) is shorter than isoform 3.
    Source sequence(s)
    AK159617, BM899883, CD578948, CJ151068
    UniProtKB/TrEMBL
    E0CX65
  6. NM_007547.4NP_031573.2  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1 precursor

    See proteins identical to NP_031573.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses an alternate in-frame splice site in the 3' coding region, compared to variant 4, resulting in an isoform (1) that is shorter than isoform 3.
    Source sequence(s)
    AF072543, AK159617, BM899883, CD578948
    Consensus CDS
    CCDS16729.1
    UniProtKB/Swiss-Prot
    P97797
    UniProtKB/TrEMBL
    Q6P6I8
    Related
    ENSMUSP00000099491, OTTMUSP00000016522, ENSMUST00000103202, OTTMUST00000036826
    Conserved Domains (4) summary
    cd00098
    Location:257336
    IgC; Immunoglobulin Constant domain
    cd00099
    Location:43145
    IgV; Immunoglobulin variable domain (IgV)
    smart00410
    Location:41145
    IG_like; Immunoglobulin like
    cl11960
    Location:145255
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000068.7 

    Range
    129592569..129632228
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498988.1XP_006499051.1  

    See proteins identical to XP_006499051.1

    UniProtKB/Swiss-Prot
    P97797
    Conserved Domains (2) summary
    cd00099
    Location:43145
    IgV; Immunoglobulin variable domain (IgV)
    smart00410
    Location:41145
    IG_like; Immunoglobulin like
  2. XM_006498986.1XP_006499049.1  

    See proteins identical to XP_006499049.1

    UniProtKB/TrEMBL
    E0CYM8
    Conserved Domains (4) summary
    cd00098
    Location:257336
    IgC; Immunoglobulin Constant domain
    cd00099
    Location:43145
    IgV; Immunoglobulin variable domain (IgV)
    smart00410
    Location:41145
    IG_like; Immunoglobulin like
    cl11960
    Location:145255
    Ig; Immunoglobulin domain
  3. XM_006498984.1XP_006499047.1  

    Related
    ENSMUSP00000124048, OTTMUSP00000047032, ENSMUST00000161620, OTTMUST00000086795
    Conserved Domains (4) summary
    cd00098
    Location:257336
    IgC; Immunoglobulin Constant domain
    cd00099
    Location:43145
    IgV; Immunoglobulin variable domain (IgV)
    smart00410
    Location:41145
    IG_like; Immunoglobulin like
    cl11960
    Location:145255
    Ig; Immunoglobulin domain
  4. XM_006498982.1XP_006499045.1  

    Conserved Domains (4) summary
    cd00098
    Location:250329
    IgC; Immunoglobulin Constant domain
    cd00099
    Location:36138
    IgV; Immunoglobulin variable domain (IgV)
    smart00410
    Location:34138
    IG_like; Immunoglobulin like
    cl11960
    Location:138248
    Ig; Immunoglobulin domain
  5. XM_006498983.1XP_006499046.1  

    Conserved Domains (4) summary
    cd00098
    Location:250329
    IgC; Immunoglobulin Constant domain
    cd00099
    Location:36138
    IgV; Immunoglobulin variable domain (IgV)
    smart00410
    Location:34138
    IG_like; Immunoglobulin like
    cl11960
    Location:138248
    Ig; Immunoglobulin domain
  6. XM_006498987.1XP_006499050.1  

    Related
    ENSMUSP00000096713, ENSMUST00000099113
    Conserved Domains (2) summary
    cd00099
    Location:43145
    IgV; Immunoglobulin variable domain (IgV)
    smart00410
    Location:41145
    IG_like; Immunoglobulin like
  7. XM_006498985.1XP_006499048.1  

    Related
    ENSMUSP00000049022, OTTMUSP00000047033, ENSMUST00000049262, OTTMUST00000086796
    Conserved Domains (4) summary
    cd00098
    Location:257336
    IgC; Immunoglobulin Constant domain
    cd00099
    Location:43145
    IgV; Immunoglobulin variable domain (IgV)
    smart00410
    Location:41145
    IG_like; Immunoglobulin like
    cl11960
    Location:145255
    Ig; Immunoglobulin domain

Alternate Mm_Celera

Genomic

  1. AC_000024.1 

    Range
    130820643..130860425
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001177646.1: Suppressed sequence

    Description
    NM_001177646.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.