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Fgf2 fibroblast growth factor 2 [ Mus musculus (house mouse) ]

Gene ID: 14173, updated on 14-Apr-2015
Official Symbol
Fgf2provided by MGI
Official Full Name
fibroblast growth factor 2provided by MGI
Primary source
MGI:MGI:95516
See related
Ensembl:ENSMUSG00000037225; Vega:OTTMUSG00000007393
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fgfb; bFGF; Fgf-2
Orthologs
See Fgf2 in MapViewer
Location:
3 18.41 cM; 3 A2-B
Exon count:
4
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 3 NC_000069.6 (37348469..37405538)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (37247575..37303752)

Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene 28S ribosomal protein S33, mitochondrial pseudogene Neighboring gene centrin 4 Neighboring gene Bardet-Biedl syndrome 12 (human) Neighboring gene fibroblast growth factor 2, opposite strand Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 6 Neighboring gene spermatogenesis associated 5 Neighboring gene predicted gene, 36412 Neighboring gene PRELI domain containing 1 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
chemoattractant activity ISO
Inferred from Sequence Orthology
more info
 
cytokine activity ISO
Inferred from Sequence Orthology
more info
 
fibroblast growth factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
fibroblast growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
growth factor activity IDA
Inferred from Direct Assay
more info
PubMed 
growth factor activity ISO
Inferred from Sequence Orthology
more info
 
heparin binding IEA
Inferred from Electronic Annotation
more info
 
ligand-dependent nuclear receptor transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
activation of MAPKK activity IDA
Inferred from Direct Assay
more info
PubMed 
angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
angiogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
angiogenesis involved in coronary vascular morphogenesis ISO
Inferred from Sequence Orthology
more info
 
branching involved in ureteric bud morphogenesis ISO
Inferred from Sequence Orthology
more info
 
cardiac muscle cell proliferation TAS
Traceable Author Statement
more info
PubMed 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
chondroblast differentiation ISO
Inferred from Sequence Orthology
more info
 
corticotropin hormone secreting cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
embryo development ending in birth or egg hatching ISO
Inferred from Sequence Orthology
more info
 
fibroblast growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
glial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
growth factor dependent regulation of skeletal muscle satellite cell proliferation ISO
Inferred from Sequence Orthology
more info
 
hyaluronan catabolic process ISO
Inferred from Sequence Orthology
more info
 
inositol phosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
lung development IDA
Inferred from Direct Assay
more info
PubMed 
lung development IGI
Inferred from Genetic Interaction
more info
PubMed 
mammary gland epithelial cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
multicellular organismal development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of fibroblast migration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of wound healing ISO
Inferred from Sequence Orthology
more info
 
organ induction IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive chemotaxis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of angiogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cardiac muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell fate specification ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cerebellar granule cell precursor proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of endothelial cell chemotaxis to fibroblast growth factor ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endothelial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of endothelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of epithelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of osteoblast differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phospholipase C activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein kinase B signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated TAS
Traceable Author Statement
more info
PubMed 
regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
regulation of endothelial cell chemotaxis to fibroblast growth factor ISO
Inferred from Sequence Orthology
more info
 
regulation of retinal cell programmed cell death IDA
Inferred from Direct Assay
more info
PubMed 
release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
 
response to axon injury IMP
Inferred from Mutant Phenotype
more info
PubMed 
stem cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
substantia nigra development IMP
Inferred from Mutant Phenotype
more info
PubMed 
thyroid-stimulating hormone-secreting cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
wound healing ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
fibroblast growth factor 2
Names
fibroblast growth factor 2
HBGF-2
basic fibroblast growth factor
heparin-binding growth factor 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008006.2NP_032032.1  fibroblast growth factor 2 precursor

    See proteins identical to NP_032032.1

    Status: VALIDATED

    Source sequence(s)
    AF065904, AL669927, BY730691, CJ098597
    Consensus CDS
    CCDS17320.1
    UniProtKB/Swiss-Prot
    P15655
    UniProtKB/TrEMBL
    Q541T2
    Related
    ENSMUSP00000037694, OTTMUSP00000047630, ENSMUST00000038885, OTTMUST00000087561
    Conserved Domains (1) summary
    cd00058
    Location:29151
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000069.6 Reference GRCm38.p3 C57BL/6J

    Range
    37348469..37405538
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535399.2XP_006535462.1  

    See proteins identical to XP_006535462.1

    Conserved Domains (1) summary
    cd00058
    Location:29162
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...
  2. XM_006535398.2XP_006535461.1  

    Conserved Domains (1) summary
    pfam00167
    Location:2893
    FGF; Fibroblast growth factor

Reference GRCm38.p3 129S1/SvImJ

Genomic

  1. NT_039248.1 Reference GRCm38.p3 129S1/SvImJ

    Range
    245047..296117
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502586.2XP_006502649.1  

    See proteins identical to XP_006502649.1

    Conserved Domains (1) summary
    cd00058
    Location:29162
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...

Reference GRCm38.p3 NOD/MrkTac

Genomic

  1. NT_039247.2 Reference GRCm38.p3 NOD/MrkTac

    Range
    2773..2988
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCm38.p3 NOD/MrkTac

Genomic

  1. NT_039252.1 Reference GRCm38.p3 NOD/MrkTac

    Range
    285936..286307
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000025.1 Alternate Mm_Celera

    Range
    37228587..37279676
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)