Display Settings:

Format

Send to:

Choose Destination

Tnfrsf11b tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) [ Mus musculus (house mouse) ]

Gene ID: 18383, updated on 11-Sep-2014
Official Symbol
Tnfrsf11bprovided by MGI
Official Full Name
tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)provided by MGI
Primary source
MGI:109587
See related
Ensembl:ENSMUSG00000063727
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Opg; TR1; OCIF
See Tnfrsf11b in Epigenomics, MapViewer
Location:
15 D1; 15
Exon count:
5
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 15 NC_000081.6 (54250619..54278484, complement)

Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene sterile alpha motif domain containing 12 Neighboring gene microRNA 28c Neighboring gene predicted gene 7489 Neighboring gene ribosomal protein L19 pseudogene Neighboring gene predicted gene 5215

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Osteoblast, organism-specific biosystem (from WikiPathways)
    Osteoblast, organism-specific biosystem
    Osteoblast
  • Osteoclast, organism-specific biosystem (from WikiPathways)
    Osteoclast, organism-specific biosystem
    Osteoclast
  • Osteoclast differentiation, organism-specific biosystem (from KEGG)
    Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
  • Osteoclast differentiation, conserved biosystem (from KEGG)
    Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix organization IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of bone resorption ISO
Inferred from Sequence Orthology
more info
 
negative regulation of odontogenesis of dentin-containing tooth IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
proteinaceous extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
tumor necrosis factor receptor superfamily member 11B
Names
tumor necrosis factor receptor superfamily member 11B
osteoprotegerin
osteoclastogenesis inhibitory factor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008764.3NP_032790.3  tumor necrosis factor receptor superfamily member 11B precursor

    See proteins identical to NP_032790.3

    Status: VALIDATED

    Source sequence(s)
    AC121114, AK140244
    Consensus CDS
    CCDS27468.1
    UniProtKB/Swiss-Prot
    O08712
    UniProtKB/TrEMBL
    Q3UK97
    Related
    ENSMUSP00000078705, ENSMUST00000079772
    Conserved Domains (2) summary
    cd00185
    Location:28124
    Blast Score: 250
    TNFR; Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and ...
    cd01670
    Location:306353
    Blast Score: 85
    Death; Death Domain: a protein-protein interaction domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000081.6 

    Range
    54250619..54278484
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000037.1 

    Range
    55801719..55829545
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)