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Ddit4 DNA-damage-inducible transcript 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 140942, updated on 3-Jun-2014
Official Symbol
Ddit4provided by RGD
Official Full Name
DNA-damage-inducible transcript 4provided by RGD
Primary source
RGD:621731
See related
Ensembl:ENSRNOG00000000577
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
Rtp801
Summary
HIF-1-responsive gene that may protect some types of cells from hypoxia and H(2)O(2)-triggered apoptosis [RGD, Feb 2006]
Annotation information
Annotation category: suggests misassembly
See Ddit4 in MapViewer
Location:
20q11
Exon count :
3
Annotation release Status Assembly Chr Location
104 current Rnor_5.0 (GCF_000001895.4) 20 NC_005119.3 (31315024..31317123, complement)

Chromosome 20 - NC_005119.3Genomic Context describing neighboring genes Neighboring gene DnaJ (Hsp40) homolog, subfamily B, member 12 Neighboring gene uncharacterized LOC102554473 Neighboring gene uncharacterized LOC102554392 Neighboring gene anaphase promoting complex subunit 16 Neighboring gene activating signal cointegrator 1 complex subunit 1 Neighboring gene sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
    MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • MicroRNAs in cancer, conserved biosystem (from KEGG)
    MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
    PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
    PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • mTOR signaling pathway, organism-specific biosystem (from KEGG)
    mTOR signaling pathway, organism-specific biosystem
    mTOR signaling pathway
  • mTOR signaling pathway, conserved biosystem (from KEGG)
    mTOR signaling pathway, conserved biosystem
    mTOR signaling pathway

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
14-3-3 protein binding IEA
Inferred from Electronic Annotation
more info
 
14-3-3 protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
brain development IMP
Inferred from Mutant Phenotype
more info
 
cell proliferation IMP
Inferred from Mutant Phenotype
more info
 
defense response to virus IEA
Inferred from Electronic Annotation
more info
 
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA
Inferred from Electronic Annotation
more info
 
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of TOR signaling IEA
Inferred from Electronic Annotation
more info
 
negative regulation of TOR signaling IMP
Inferred from Mutant Phenotype
more info
 
negative regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
 
negative regulation of glycolytic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of glycolytic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of intracellular signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of peptidyl-threonine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 
neuron migration IMP
Inferred from Mutant Phenotype
more info
 
neurotrophin TRK receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 
positive regulation of neuron death IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein complex disassembly IEA
Inferred from Electronic Annotation
more info
 
protein complex disassembly ISO
Inferred from Sequence Orthology
more info
 
reactive oxygen species metabolic process IEA
Inferred from Electronic Annotation
more info
 
reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
intracellular ISO
Inferred from Sequence Orthology
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
DNA damage-inducible transcript 4 protein
Names
DNA damage-inducible transcript 4 protein
REDD-1
HIF-1 responsive RTP801
HIF-1 responsive protein RTP801
DNA-damage-inducible transcript 4 protein
protein regulated in development and DNA damage response 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080906.2NP_543182.1  DNA damage-inducible transcript 4 protein

    See proteins identical to NP_543182.1

    Status: PROVISIONAL

    Source sequence(s)
    AF334162
    UniProtKB/Swiss-Prot
    Q8VHZ9
    Related
    ENSRNOP00000000703, ENSRNOT00000000703
    Conserved Domains (1) summary
    pfam07809
    Location:101220
    Blast Score: 446
    RTP801_C; RTP801 C-terminal region

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_5.0 Primary Assembly

Genomic

  1. NC_005119.3 

    Range
    31315024..31317123
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000088.1 

    Range
    29333162..29335357
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Supplemental Content

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