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    ADGRB1 adhesion G protein-coupled receptor B1 [ Homo sapiens (human) ]

    Gene ID: 575, updated on 12-Jun-2016
    Official Symbol
    ADGRB1provided by HGNC
    Official Full Name
    adhesion G protein-coupled receptor B1provided by HGNC
    Primary source
    HGNC:HGNC:943
    See related
    Ensembl:ENSG00000181790 HPRD:04062; MIM:602682; Vega:OTTHUMG00000164732
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BAI1; GDAIF
    Summary
    Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    8q24.3
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 8 NC_000008.11 (142449703..142545009)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (143545377..143626369)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986983 Neighboring gene t-SNARE domain containing 1 Neighboring gene RNA, 7SL, cytoplasmic 260, pseudogene Neighboring gene maestro heat like repeat family member 4, pseudogene Neighboring gene activity regulated cytoskeleton associated protein

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat LRRK2 kinase inhibition suppresses HIV-1 Tat-induced upregulation of phosphatidylserine receptor BAI1 in microglia cells PubMed

    Go to the HIV-1, Human Interaction Database

    • p53 signaling pathway, organism-specific biosystem (from KEGG)
      p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
    • p53 signaling pathway, conserved biosystem (from KEGG)
      p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ41988

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    G-protein coupled receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    axonogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    peripheral nervous system development TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of synapse assembly IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cell-cell junction TAS
    Traceable Author Statement
    more info
    PubMed 
    integral component of membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    brain-specific angiogenesis inhibitor 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001702.2NP_001693.2  brain-specific angiogenesis inhibitor 1 precursor

      See identical proteins and their annotated locations for NP_001693.2

      Status: REVIEWED

      Source sequence(s)
      AB005297, AC139676
      Consensus CDS
      CCDS64985.1
      UniProtKB/Swiss-Prot
      O14514
      Related
      ENSP00000313046, ENST00000323289
      Conserved Domains (5) summary
      smart00303
      Location:880938
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:577643
      HormR; Domain present in hormone receptors
      smart00209
      Location:412462
      TSP1; Thrombospondin type 1 repeats
      pfam00002
      Location:9441180
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam12003
      Location:653875
      DUF3497; Domain of unknown function (DUF3497)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p7 Primary Assembly

      Range
      142449703..142545009
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017013695.1XP_016869184.1  

    2. XM_017013691.1XP_016869180.1  

    3. XM_017013692.1XP_016869181.1  

    4. XM_017013696.1XP_016869185.1  

    5. XM_017013694.1XP_016869183.1  

    6. XM_011517199.2XP_011515501.1  

      See identical proteins and their annotated locations for XP_011515501.1

      UniProtKB/Swiss-Prot
      O14514
      Related
      ENSP00000430945, OTTHUMP00000227339, ENST00000517894, OTTHUMT00000379963
      Conserved Domains (5) summary
      smart00303
      Location:880938
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:577643
      HormR; Domain present in hormone receptors
      smart00209
      Location:412462
      TSP1; Thrombospondin type 1 repeats
      pfam00002
      Location:9441180
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam12003
      Location:653875
      DUF3497; Domain of unknown function (DUF3497)
    7. XM_017013693.1XP_016869182.1  

    8. XM_017013697.1XP_016869186.1  

    9. XM_011517202.2XP_011515504.1  

      Related
      ENSP00000427783, OTTHUMP00000227746, ENST00000521208, OTTHUMT00000380655
      Conserved Domains (5) summary
      smart00303
      Location:880938
      GPS; G-protein-coupled receptor proteolytic site domain
      smart00008
      Location:577643
      HormR; Domain present in hormone receptors
      smart00209
      Location:412462
      TSP1; Thrombospondin type 1 repeats
      pfam12003
      Location:653875
      DUF3497; Domain of unknown function (DUF3497)
      cl21587
      Location:9441140
      7tm_2; 7 transmembrane receptor (Secretin family)

    Alternate CHM1_1.1

    Genomic

    1. NC_018919.2 Alternate CHM1_1.1

      Range
      143585613..143666276
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)