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GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 [ Homo sapiens (human) ]

Gene ID: 84706, updated on 11-Sep-2014
Official Symbol
GPT2provided by HGNC
Official Full Name
glutamic pyruvate transaminase (alanine aminotransferase) 2provided by HGNC
Primary source
HGNC:HGNC:18062
See related
Ensembl:ENSG00000166123; HPRD:06307; MIM:138210; Vega:OTTHUMG00000132541
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ALT2
Summary
This gene encodes one of the two pyridoxal enzymes which catalyze a reversible transamination reaction to yield glutamate and pyruvate so these enzymes participate in amino acid metabolism and gluconeogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
See GPT2 in Epigenomics, MapViewer
Location:
16q12.1
Exon count:
14
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 16 NC_000016.10 (46884396..46931289)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (46918308..46965201)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene chromosome 16 open reading frame 87 Neighboring gene creatine kinase B pseudogene 1 Neighboring gene DnaJ (Hsp40) homolog, subfamily A, member 2 Neighboring gene neuropilin (NRP) and tolloid (TLL)-like 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of glutamic pyruvate transaminase (alanine aminotransferase) 2 (GPT2) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

  • 2-Oxocarboxylic acid metabolism, organism-specific biosystem (from KEGG)
    2-Oxocarboxylic acid metabolism, organism-specific biosystem2-Oxocarboxylic acids, also called 2-oxo acids and alpha-keto acids, are the most elementary set of metabolites that includes pyruvate (2-oxopropanoate), 2-oxobutanoate, oxaloacetate (2-oxosuccinate)...
  • 2-Oxocarboxylic acid metabolism, conserved biosystem (from KEGG)
    2-Oxocarboxylic acid metabolism, conserved biosystem2-Oxocarboxylic acids, also called 2-oxo acids and alpha-keto acids, are the most elementary set of metabolites that includes pyruvate (2-oxopropanoate), 2-oxobutanoate, oxaloacetate (2-oxosuccinate)...
  • Alanine, aspartate and glutamate metabolism, organism-specific biosystem (from KEGG)
    Alanine, aspartate and glutamate metabolism, organism-specific biosystem
    Alanine, aspartate and glutamate metabolism
  • Alanine, aspartate and glutamate metabolism, conserved biosystem (from KEGG)
    Alanine, aspartate and glutamate metabolism, conserved biosystem
    Alanine, aspartate and glutamate metabolism
  • Amino acid synthesis and interconversion (transamination), organism-specific biosystem (from REACTOME)
    Amino acid synthesis and interconversion (transamination), organism-specific biosystemThese reactions mediate the synthesis of aspartate, asparagine, glutamate, and glutamine from ammonia and intermediates of glycolysis, and allow the utilization of the carbon atoms from these four am...
  • Biosynthesis of amino acids, organism-specific biosystem (from KEGG)
    Biosynthesis of amino acids, organism-specific biosystemThis map presents a modular architecture of the biosynthesis pathways of twenty amino acids, which may be viewed as consisting of the core part and its extensions. The core part is the KEGG module fo...
  • Biosynthesis of amino acids, conserved biosystem (from KEGG)
    Biosynthesis of amino acids, conserved biosystemThis map presents a modular architecture of the biosynthesis pathways of twenty amino acids, which may be viewed as consisting of the core part and its extensions. The core part is the KEGG module fo...
  • Carbon metabolism, organism-specific biosystem (from KEGG)
    Carbon metabolism, organism-specific biosystemCarbon metabolism is the most basic aspect of life. This map presents an overall view of central carbon metabolism, where the number of carbons is shown for each compound denoted by a circle, excludi...
  • Carbon metabolism, conserved biosystem (from KEGG)
    Carbon metabolism, conserved biosystemCarbon metabolism is the most basic aspect of life. This map presents an overall view of central carbon metabolism, where the number of carbons is shown for each compound denoted by a circle, excludi...
  • Metabolic pathways, organism-specific biosystem (from KEGG)
    Metabolic pathways, organism-specific biosystem
    Metabolic pathways
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of amino acids and derivatives, organism-specific biosystem (from REACTOME)
    Metabolism of amino acids and derivatives, organism-specific biosystemThis group of reactions is responsible for: 1) the breakdown of amino acids; 2) the synthesis of urea from ammonia and amino groups generated by amino acid breakdown; 3) the synthesis of the ten amin...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
L-alanine:2-oxoglutarate aminotransferase activity EXP
Inferred from Experiment
more info
 
L-alanine:2-oxoglutarate aminotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
2-oxoglutarate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
L-alanine catabolic process IEA
Inferred from Electronic Annotation
more info
 
L-alanine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
cellular amino acid biosynthetic process TAS
Traceable Author Statement
more info
 
cellular nitrogen compound metabolic process TAS
Traceable Author Statement
more info
 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
mitochondrial matrix TAS
Traceable Author Statement
more info
 
Preferred Names
alanine aminotransferase 2
Names
alanine aminotransferase 2
GPT 2
glutamic--alanine transaminase 2
glutamic--pyruvic transaminase 2
glutamic-pyruvate transaminase 2
glutamate pyruvate transaminase 2
NP_001135938.1
NP_597700.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142466.1NP_001135938.1  alanine aminotransferase 2 isoform 2

    See proteins identical to NP_001135938.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC018845, AI990701, AY029173, DA400677
    Consensus CDS
    CCDS45478.1
    UniProtKB/Swiss-Prot
    Q8TD30
    Related
    ENSP00000413804, OTTHUMP00000253952, ENST00000440783, OTTHUMT00000430623
    Conserved Domains (2) summary
    cd00609
    Location:25413
    AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
    pfam00155
    Location:10411
    Aminotran_1_2; Aminotransferase class I and II
  2. NM_133443.2NP_597700.1  alanine aminotransferase 2 isoform 1

    See proteins identical to NP_597700.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC018845, AI990701, AY029173
    Consensus CDS
    CCDS10725.1
    UniProtKB/TrEMBL
    A0A024R6R2
    UniProtKB/Swiss-Prot
    Q8TD30
    Related
    ENSP00000345282, OTTHUMP00000163363, ENST00000340124, OTTHUMT00000255741
    Conserved Domains (2) summary
    cd00609
    Location:125513
    AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
    PTZ00377
    Location:48523
    PTZ00377; alanine aminotransferase; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000016.10 

    Range
    46884396..46931289
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000148.1 

    Range
    32808713..32855581
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018927.2 

    Range
    48325402..48372269
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)