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    FASN fatty acid synthase [ Homo sapiens (human) ]

    Gene ID: 2194, updated on 31-Jan-2016
    Official Symbol
    FASNprovided by HGNC
    Official Full Name
    fatty acid synthaseprovided by HGNC
    Primary source
    HGNC:HGNC:3594
    See related
    Ensembl:ENSG00000169710; HPRD:02567; MIM:600212; Vega:OTTHUMG00000178527
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FAS; OA-519; SDR27X1
    Summary
    The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008]
    Orthologs
    See FASN in Epigenomics, MapViewer
    Location:
    17q25
    Exon count:
    43
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 17 NC_000017.11 (82078338..82098289, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (80036214..80056106, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Neighboring gene G protein pathway suppressor 1 Neighboring gene dihydrouridine synthase 1-like Neighboring gene coiled-coil domain containing 57 Neighboring gene solute carrier family 16 (monocarboxylate transporter), member 3 Neighboring gene microRNA 6787

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify fatty acid synthase (FASN), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify fatty acid synthase (FASN), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify fatty acid synthase (FASN), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Cellular biotinylated fatty acid synthase protein (FASN) is incorporated into HIV-1 Gag virus-like particles PubMed
    gag Tandem affinity purification and mass spectrometry analysis identify fatty acid synthase (FASN), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC14367, MGC15706

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
     
    3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
     
    3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
     
    3-oxoacyl-[acyl-carrier-protein] synthase activity IEA
    Inferred from Electronic Annotation
    more info
     
    NADPH binding IEA
    Inferred from Electronic Annotation
    more info
     
    [acyl-carrier-protein] S-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    [acyl-carrier-protein] S-malonyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    drug binding IEA
    Inferred from Electronic Annotation
    more info
     
    enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity IEA
    Inferred from Electronic Annotation
    more info
     
    enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity IEA
    Inferred from Electronic Annotation
    more info
     
    fatty acid synthase activity TAS
    Traceable Author Statement
    more info
     
    myristoyl-[acyl-carrier-protein] hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    oleoyl-[acyl-carrier-protein] hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    palmitoyl-[acyl-carrier-protein] hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    poly(A) RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acetyl-CoA metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    cellular lipid metabolic process TAS
    Traceable Author Statement
    more info
     
    cellular response to interleukin-4 IEA
    Inferred from Electronic Annotation
    more info
     
    energy reserve metabolic process TAS
    Traceable Author Statement
    more info
     
    fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    fatty acid metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    long-chain fatty-acyl-CoA biosynthetic process TAS
    Traceable Author Statement
    more info
     
    mammary gland development IEA
    Inferred from Electronic Annotation
    more info
     
    osteoblast differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    pantothenate metabolic process TAS
    Traceable Author Statement
    more info
     
    positive regulation of cellular metabolic process TAS
    Traceable Author Statement
    more info
     
    small molecule metabolic process TAS
    Traceable Author Statement
    more info
     
    triglyceride biosynthetic process TAS
    Traceable Author Statement
    more info
     
    vitamin metabolic process TAS
    Traceable Author Statement
    more info
     
    water-soluble vitamin metabolic process TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glycogen granule IEA
    Inferred from Electronic Annotation
    more info
     
    melanosome IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    Preferred Names
    fatty acid synthase
    Names
    short chain dehydrogenase/reductase family 27X, member 1
    NP_004095.4

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004104.4NP_004095.4  fatty acid synthase

      See identical proteins and their annotated locations for NP_004095.4

      Status: REVIEWED

      Source sequence(s)
      BC007267, BC021544, BC063242, S80437
      Consensus CDS
      CCDS11801.1
      UniProtKB/Swiss-Prot
      P49327
      Related
      ENSP00000304592, OTTHUMP00000259630, ENST00000306749, OTTHUMT00000442369
      Conserved Domains (12) summary
      pfam00698
      Location:493810
      Acyl_transf_1; Acyl transferase domain
      cd05195
      Location:15661854
      enoyl_red; enoyl reductase of polyketide synthase
      cd08954
      Location:18762112
      KR_1_FAS_SDR_x; beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 1, complex (x) SDRs
      smart00823
      Location:21112179
      PKS_PP; Phosphopantetheine attachment site
      smart00829
      Location:15641854
      PKS_ER; Enoylreductase
      COG3321
      Location:11022
      PksD; Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism]
      cd00833
      Location:2404
      PKS; polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or ...
      pfam00106
      Location:19012053
      adh_short; short chain dehydrogenase
      pfam00975
      Location:22422487
      Thioesterase; Thioesterase domain
      pfam08242
      Location:12431342
      Methyltransf_12; Methyltransferase domain
      pfam13847
      Location:12391383
      Methyltransf_31; Methyltransferase domain
      pfam14765
      Location:8741106
      PS-DH; Polyketide synthase dehydratase

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p2 Primary Assembly

      Range
      82078338..82098289 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011523538.1XP_011521840.1  

      See identical proteins and their annotated locations for XP_011521840.1

      UniProtKB/Swiss-Prot
      P49327
      Conserved Domains (12) summary
      pfam00698
      Location:493810
      Acyl_transf_1; Acyl transferase domain
      cd05195
      Location:15661854
      enoyl_red; enoyl reductase of polyketide synthase
      cd08954
      Location:18762112
      KR_1_FAS_SDR_x; beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 1, complex (x) SDRs
      smart00823
      Location:21112179
      PKS_PP; Phosphopantetheine attachment site
      smart00829
      Location:15641854
      PKS_ER; Enoylreductase
      COG3321
      Location:11022
      PksD; Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism]
      cd00833
      Location:2404
      PKS; polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or ...
      pfam00106
      Location:19012053
      adh_short; short chain dehydrogenase
      pfam00975
      Location:22422487
      Thioesterase; Thioesterase domain
      pfam08242
      Location:12431342
      Methyltransf_12; Methyltransferase domain
      pfam13847
      Location:12391383
      Methyltransf_31; Methyltransferase domain
      pfam14765
      Location:8741106
      PS-DH; Polyketide synthase dehydratase

    Alternate CHM1_1.1

    Genomic

    1. NC_018928.2 Alternate CHM1_1.1

      Range
      80122440..80142272 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)