Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    IL17F interleukin 17F [ Homo sapiens (human) ]

    Gene ID: 112744, updated on 17-Jan-2016
    Official Symbol
    IL17Fprovided by HGNC
    Official Full Name
    interleukin 17Fprovided by HGNC
    Primary source
    HGNC:HGNC:16404
    See related
    Ensembl:ENSG00000112116; HPRD:16224; MIM:606496; Vega:OTTHUMG00000014845
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ML1; ML-1; CANDF6; IL-17F
    Summary
    The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. [provided by RefSeq, Jul 2008]
    Orthologs
    See IL17F in Epigenomics, MapViewer
    Location:
    6p12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 6 NC_000006.12 (52236681..52245689, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (52101484..52109298, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene interleukin 17A Neighboring gene uncharacterized LOC102724327 Neighboring gene uncharacterized LOC105375088 Neighboring gene solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 pseudogene 1 Neighboring gene minichromosome maintenance complex component 3

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Candidiasis, familial, 6
    MedGen: C3151405 OMIM: 613956 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303.
    NHGRI GWA Catalog
    • IL17 signaling pathway, organism-specific biosystem (from WikiPathways)
      IL17 signaling pathway, organism-specific biosystemInterleukin 17 is a family of cytokines that acts as potent mediators in delayed-type reactions by increasing chemokine production in various tissues to recruit monocytes and neutrophils to the site ...
    • IL23-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      IL23-mediated signaling events, organism-specific biosystem
      IL23-mediated signaling events
    • Inflammatory bowel disease (IBD), organism-specific biosystem (from KEGG)
      Inflammatory bowel disease (IBD), organism-specific biosystemInflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract due to environmental and geneti...
    • Inflammatory bowel disease (IBD), conserved biosystem (from KEGG)
      Inflammatory bowel disease (IBD), conserved biosystemInflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract due to environmental and geneti...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cytokine activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytokine binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytokine receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular region NAS
    Non-traceable Author Statement
    more info
    PubMed 
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    interleukin-17F
    Names
    cytokine ML-1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_031869.1 RefSeqGene

      Range
      5001..12815
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_356

    mRNA and Protein(s)

    1. NM_052872.3NP_443104.1  interleukin-17F precursor

      See identical proteins and their annotated locations for NP_443104.1

      Status: REVIEWED

      Source sequence(s)
      AF332389, BC070124
      Consensus CDS
      CCDS4938.1
      UniProtKB/Swiss-Prot
      Q96PD4
      Related
      ENSP00000337432, OTTHUMP00000016602, ENST00000336123, OTTHUMT00000040901
      Conserved Domains (1) summary
      pfam06083
      Location:76156
      IL17; Interleukin-17

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p2 Primary Assembly

      Range
      52236681..52245689 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011514276.1XP_011512578.1  

      See identical proteins and their annotated locations for XP_011512578.1

      UniProtKB/Swiss-Prot
      Q96PD4
      Conserved Domains (1) summary
      pfam06083
      Location:76156
      IL17; Interleukin-17

    Alternate CHM1_1.1

    Genomic

    1. NC_018917.2 Alternate CHM1_1.1

      Range
      52103743..52111557 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)