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Shank1 SH3 and multiple ankyrin repeat domains 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 78957, updated on 8-Dec-2014
Official Symbol
Shank1provided by RGD
Official Full Name
SH3 and multiple ankyrin repeat domains 1provided by RGD
Primary source
RGD:621011
See related
Ensembl:ENSRNOG00000019207
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
Spank1; Sstrip; Shank1a
Summary
a scaffold protein in the post synaptic density that forms a complex with GKAP and PSD-95 [RGD, Feb 2006]
See Shank1 in MapViewer
Location:
1q22
Exon count:
26
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (100297157..100344377)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (101362243..101410338)

Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103691109 Neighboring gene formyl peptide receptor-related sequence 4-like Neighboring gene uncharacterized LOC103691110 Neighboring gene C-type lectin domain family 11, member A Neighboring gene hypothetical LOC292874 Neighboring gene synaptotagmin III

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Glutamatergic synapse, organism-specific biosystem (from KEGG)
    Glutamatergic synapse, organism-specific biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
  • Glutamatergic synapse, conserved biosystem (from KEGG)
    Glutamatergic synapse, conserved biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
GKAP/Homer scaffold activity IDA
Inferred from Direct Assay
more info
PubMed 
GKAP/Homer scaffold activity ISO
Inferred from Sequence Orthology
more info
 
SH3 domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
ankyrin repeat binding IPI
Inferred from Physical Interaction
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ionotropic glutamate receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
ionotropic glutamate receptor binding ISO
Inferred from Sequence Orthology
more info
 
protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor signaling complex scaffold activity IDA
Inferred from Direct Assay
more info
PubMed 
scaffold protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
somatostatin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
adult behavior IEA
Inferred from Electronic Annotation
more info
 
adult behavior ISO
Inferred from Sequence Orthology
more info
 
associative learning ISO
Inferred from Sequence Orthology
more info
 
associative learning ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoskeletal anchoring at plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
dendritic spine morphogenesis ISO
Inferred from Sequence Orthology
more info
 
dendritic spine morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
determination of affect IEA
Inferred from Electronic Annotation
more info
 
determination of affect ISO
Inferred from Sequence Orthology
more info
 
habituation ISO
Inferred from Sequence Orthology
more info
 
habituation ISS
Inferred from Sequence or Structural Similarity
more info
 
long-term memory ISO
Inferred from Sequence Orthology
more info
 
long-term memory ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of actin filament bundle assembly ISO
Inferred from Sequence Orthology
more info
 
negative regulation of actin filament bundle assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
neuromuscular process controlling balance ISO
Inferred from Sequence Orthology
more info
 
neuromuscular process controlling balance ISS
Inferred from Sequence or Structural Similarity
more info
 
olfactory behavior ISO
Inferred from Sequence Orthology
more info
 
olfactory behavior ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of dendritic spine development IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of excitatory postsynaptic membrane potential ISO
Inferred from Sequence Orthology
more info
 
positive regulation of excitatory postsynaptic membrane potential ISS
Inferred from Sequence or Structural Similarity
more info
 
protein complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
protein localization to synapse ISO
Inferred from Sequence Orthology
more info
 
protein localization to synapse ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity ISO
Inferred from Sequence Orthology
more info
 
regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
righting reflex ISO
Inferred from Sequence Orthology
more info
 
righting reflex ISS
Inferred from Sequence or Structural Similarity
more info
 
social behavior IEA
Inferred from Electronic Annotation
more info
 
social behavior ISO
Inferred from Sequence Orthology
more info
 
synapse maturation IDA
Inferred from Direct Assay
more info
PubMed 
vocalization behavior IEA
Inferred from Electronic Annotation
more info
 
vocalization behavior ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
colocalizes_with N-methyl-D-aspartate selective glutamate receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
dendrite ISO
Inferred from Sequence Orthology
more info
 
dendrite NAS
Non-traceable Author Statement
more info
PubMed 
dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
dendritic spine ISO
Inferred from Sequence Orthology
more info
 
excitatory synapse ISO
Inferred from Sequence Orthology
more info
 
excitatory synapse ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular NAS
Non-traceable Author Statement
more info
PubMed 
colocalizes_with ionotropic glutamate receptor complex ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with ionotropic glutamate receptor complex ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
neuron projection ISO
Inferred from Sequence Orthology
more info
 
neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
 
neuronal postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
neuronal postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
synapse IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
SH3 and multiple ankyrin repeat domains protein 1
Names
SH3 and multiple ankyrin repeat domains protein 1
SPANK-1
synamon
SSTR-interacting protein
SH3/ankyrin domain gene 1
GKAP/SAPAP interacting protein
GKAP/SAPAP-interacting protein
SAPAP-interacting protein synamon
somatostatin receptor-interacting protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031751.2NP_113939.2  SH3 and multiple ankyrin repeat domains protein 1

    See proteins identical to NP_113939.2

    Status: PROVISIONAL

    Source sequence(s)
    AF159046
    UniProtKB/Swiss-Prot
    Q9WV48
    Related
    ENSRNOP00000026100, ENSRNOT00000026100
    Conserved Domains (7) summary
    cd09506
    Location:21002165
    SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
    smart00454
    Location:21032167
    SAM; Sterile alpha motif
    cd11982
    Location:557608
    SH3_Shank1; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 1
    cd00204
    Location:274399
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd00992
    Location:661754
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam12796
    Location:318402
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:280328
    Ank_4; Ankyrin repeats (many copies)

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005100.4 

    Range
    100297157..100344377
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008759414.1XP_008757636.1  

    UniProtKB/Swiss-Prot
    Q9WV48
    Conserved Domains (7) summary
    cd09506
    Location:20922157
    SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
    smart00454
    Location:20952159
    SAM; Sterile alpha motif
    cd11982
    Location:557608
    SH3_Shank1; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 1
    cd00204
    Location:274399
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd00992
    Location:661754
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam12796
    Location:318402
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:280328
    Ank_4; Ankyrin repeats (many copies)
  2. XM_008759415.1XP_008757637.1  

    UniProtKB/Swiss-Prot
    Q9WV48
    Conserved Domains (7) summary
    cd09506
    Location:20912156
    SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
    smart00454
    Location:20942158
    SAM; Sterile alpha motif
    cd11982
    Location:557608
    SH3_Shank1; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 1
    cd00204
    Location:274399
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd00992
    Location:652745
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam12796
    Location:318402
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:280328
    Ank_4; Ankyrin repeats (many copies)
  3. XM_008759417.1XP_008757639.1  

    UniProtKB/Swiss-Prot
    Q9WV48
    Conserved Domains (5) summary
    cd00204
    Location:274399
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd00992
    Location:661754
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam12796
    Location:318402
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:280328
    Ank_4; Ankyrin repeats (many copies)
    cl17036
    Location:557608
    SH3; Src Homology 3 domain superfamily
  4. XM_008759416.1XP_008757638.1  

    Conserved Domains (5) summary
    cd00204
    Location:274399
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd00992
    Location:661754
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam12796
    Location:318402
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:280328
    Ank_4; Ankyrin repeats (many copies)
    cl17036
    Location:557608
    SH3; Src Homology 3 domain superfamily

Alternate Rn_Celera

Genomic

  1. AC_000069.1 

    Range
    89071051..89118344
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)