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    METTL17 methyltransferase like 17 [ Homo sapiens (human) ]

    Gene ID: 64745, updated on 9-Jun-2016
    Official Symbol
    METTL17provided by HGNC
    Official Full Name
    methyltransferase like 17provided by HGNC
    Primary source
    HGNC:HGNC:19280
    See related
    Ensembl:ENSG00000165792 HPRD:13379; MIM:616091; Vega:OTTHUMG00000029610
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    METT11D1
    Orthologs
    Location:
    14q11.2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 14 NC_000014.9 (20989806..20997035)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (21457432..21465194)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 189, pseudogene Neighboring gene coiled-coil domain containing 107 pseudogene Neighboring gene uncharacterized LOC101929718 Neighboring gene solute carrier family 39 member 2 Neighboring gene NDRG family member 2 Neighboring gene microRNA 6717

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ20859

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    copper ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    methylation IEA
    Inferred from Electronic Annotation
    more info
     
    translation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
     
    ribosome IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    methyltransferase-like protein 17, mitochondrial
    Names
    false p73 target gene protein
    methyltransferase 11 domain containing 1
    methyltransferase 11 domain-containing protein 1
    protein RSM22 homolog, mitochondrial

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001029991.1NP_001025162.1  methyltransferase-like protein 17, mitochondrial isoform 1 precursor

      See identical proteins and their annotated locations for NP_001025162.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
      Source sequence(s)
      AK024512, AL355922, BG437086
      Consensus CDS
      CCDS41913.1
      UniProtKB/Swiss-Prot
      Q9H7H0
      Related
      ENSP00000372445, OTTHUMP00000164258, ENST00000382985, OTTHUMT00000073805
      Conserved Domains (2) summary
      COG0500
      Location:191297
      SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
      cl17173
      Location:155421
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    2. NM_022734.2NP_073571.1  methyltransferase-like protein 17, mitochondrial isoform 2 precursor

      See identical proteins and their annotated locations for NP_073571.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks a segment in the 3' coding region, compared to variant 1, that causes a frameshift. The resulting protein (isoform 2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK024512, AL355922, BC005053, BG437086
      Consensus CDS
      CCDS9562.1
      UniProtKB/Swiss-Prot
      Q9H7H0
      UniProtKB/TrEMBL
      A0A0S2Z5L8
      Related
      ENSP00000343041, OTTHUMP00000028294, ENST00000339374, OTTHUMT00000073804
      Conserved Domains (2) summary
      COG0500
      Location:191297
      SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
      cl17173
      Location:155438
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p7 Primary Assembly

      Range
      20989806..20997035
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017021601.1XP_016877090.1  

    2. XM_006720236.2XP_006720299.1  

      Conserved Domains (2) summary
      COG0500
      Location:33139
      SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
      cl17173
      Location:2263
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    Alternate CHM1_1.1

    Genomic

    1. NC_018925.2 Alternate CHM1_1.1

      Range
      21460070..21467296
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001029992.1: Suppressed sequence

      Description
      NM_001029992.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.