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DYNLL1 dynein, light chain, LC8-type 1 [ Homo sapiens (human) ]

Gene ID: 8655, updated on 6-Jul-2014
Official Symbol
DYNLL1provided by HGNC
Official Full Name
dynein, light chain, LC8-type 1provided by HGNC
Primary source
HGNC:15476
See related
Ensembl:ENSG00000088986; HPRD:03334; MIM:601562; Vega:OTTHUMG00000169368
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LC8; PIN; DLC1; DLC8; LC8a; DNCL1; hdlc1; DNCLC1
Summary
Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
See DYNLL1 in Epigenomics, MapViewer
Location:
12q24.23
Exon count :
4
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 12 NC_000012.12 (120469857..120498495)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (120907660..120936298)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L31 pseudogene 52 Neighboring gene glutamyl-tRNA(Gln) amidotransferase, subunit C Neighboring gene serine/arginine-rich splicing factor 9 Neighboring gene DYNLL1 antisense RNA 1 Neighboring gene coenzyme Q5 homolog, methyltransferase (S. cerevisiae) Neighboring gene ribosomal protein L29 pseudogene 24 Neighboring gene ring finger protein 10

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Tat, p14 tat Interaction of HIV-1 Tat with DNCL1 in T-cells is identified by a proteomic strategy based on affinity chromatography PubMed

Go to the HIV-1, Human Protein Interaction Database

  • Activation of BH3-only proteins, organism-specific biosystem (from REACTOME)
    Activation of BH3-only proteins, organism-specific biosystemThe BH3-only members act as sentinels that selectively trigger apoptosis in response to developmental cues or stress-signals like DNA damages. Widely expressed mammalian BH3-only proteins are thought...
  • Activation of BIM and translocation to mitochondria, organism-specific biosystem (from REACTOME)
    Activation of BIM and translocation to mitochondria, organism-specific biosystemBIM acts as a sentinel to check the integrity of the cytoskeleton. It exists as two variant proteins: BIM-EL and BIM-L. In healthy cells, these two isoforms are sequestered to the dynein motor comple...
  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Apoptosis, organism-specific biosystem (from REACTOME)
    Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystem
    Cell Cycle
  • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
    Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
  • Centrosome maturation, organism-specific biosystem (from REACTOME)
    Centrosome maturation, organism-specific biosystemThe centrosome is the primary microtubule organizing center (MTOC) in vertebrate cells and plays an important role in orchestrating the formation of the mitotic spindle. Centrosome maturation is an ...
  • G2/M Transition, organism-specific biosystem (from REACTOME)
    G2/M Transition, organism-specific biosystemCyclin A can also form complexes with Cdc2 (Cdk1). Together with three B-type cyclins, Cdc2 (Cdk1) regulates the transition from G2 into mitosis. These complexes are activated by dephosphorylation of...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Intrinsic Pathway for Apoptosis, organism-specific biosystem (from REACTOME)
    Intrinsic Pathway for Apoptosis, organism-specific biosystemThe intrinsic (Bcl-2 inhibitable or mitochondrial) pathway of apoptosis functions in response to various types of intracellular stress including growth factor withdrawal, DNA damage, unfolding stress...
  • Loss of Nlp from mitotic centrosomes, organism-specific biosystem (from REACTOME)
    Loss of Nlp from mitotic centrosomes, organism-specific biosystemDuring interphase, Nlp interacts with gamma-tubulin ring complexes (gamma-TuRC), and is thought to contribute to the organization of interphase microtubules (Casenghi et al.,2003). Plk1 is activated...
  • Loss of proteins required for interphase microtubule organization from the centrosome, organism-specific biosystem (from REACTOME)
    Loss of proteins required for interphase microtubule organization from the centrosome, organism-specific biosystemIn addition to recruiting proteins and complexes necessary for increased microtubule nucleation, centrosomal maturation involves the loss of proteins involved in interphase microtubule organization ...
  • MHC class II antigen presentation, organism-specific biosystem (from REACTOME)
    MHC class II antigen presentation, organism-specific biosystemAntigen presenting cells (APCs) such as B cells, dendritic cells (DCs) and monocytes/macrophages express major histocompatibility complex class II molecules (MHC II) at their surface and present exog...
  • Mitotic G2-G2/M phases, organism-specific biosystem (from REACTOME)
    Mitotic G2-G2/M phases, organism-specific biosystem
    Mitotic G2-G2/M phases
  • Recruitment of mitotic centrosome proteins and complexes, organism-specific biosystem (from REACTOME)
    Recruitment of mitotic centrosome proteins and complexes, organism-specific biosystemThe mitotic spindle becomes established once centrosomes have migrated to opposite poles and the nuclear envelope has broken down. During this stage, interphase centrosomes mature into mitotic centro...
  • Regulation of PLK1 Activity at G2/M Transition, organism-specific biosystem (from REACTOME)
    Regulation of PLK1 Activity at G2/M Transition, organism-specific biosystemThe kinase activity of PLK1 is required for cell cycle progression as PLK1 phosphorylates and regulates a number of cellular proteins during mitosis. Centrosomic AURKA (Aurora A kinase), catalyticall...
  • Vasopressin-regulated water reabsorption, organism-specific biosystem (from KEGG)
    Vasopressin-regulated water reabsorption, organism-specific biosystemIn the kidney, the antidiuretic hormone vasopressin (AVP) is a critical regulator of water homeostasis by controlling the water movement from lumen to the interstitium for water reabsorption and adju...
  • Vasopressin-regulated water reabsorption, conserved biosystem (from KEGG)
    Vasopressin-regulated water reabsorption, conserved biosystemIn the kidney, the antidiuretic hormone vasopressin (AVP) is a critical regulator of water homeostasis by controlling the water movement from lumen to the interstitium for water reabsorption and adju...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enzyme binding IEA
Inferred from Electronic Annotation
more info
 
motor activity IEA
Inferred from Electronic Annotation
more info
 
nitric-oxide synthase regulator activity IEA
Inferred from Electronic Annotation
more info
 
protein C-terminus binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
actin cytoskeleton organization TAS
Traceable Author Statement
more info
PubMed 
anatomical structure morphogenesis TAS
Traceable Author Statement
more info
PubMed 
antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
Traceable Author Statement
more info
 
apoptotic process TAS
Traceable Author Statement
more info
 
female gamete generation TAS
Traceable Author Statement
more info
PubMed 
intrinsic apoptotic signaling pathway TAS
Traceable Author Statement
more info
 
microtubule-based process IEA
Inferred from Electronic Annotation
more info
 
mitotic cell cycle TAS
Traceable Author Statement
more info
 
negative regulation of phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS
Traceable Author Statement
more info
 
regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
substantia nigra development IEP
Inferred from Expression Pattern
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transport IEA
Inferred from Electronic Annotation
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
colocalizes_with COP9 signalosome IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic dynein complex ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
 
kinetochore IDA
Inferred from Direct Assay
more info
 
microtubule IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
mitotic spindle IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
dynein light chain 1, cytoplasmic
Names
dynein light chain 1, cytoplasmic
8 kDa dynein light chain
cytoplasmic dynein light polypeptide
dynein, cytoplasmic, light polypeptide 1
protein inhibitor of neuronal nitric oxide synthase

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037494.1NP_001032583.1  dynein light chain 1, cytoplasmic

    See proteins identical to NP_001032583.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. . Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    BG474448, BI491360, CB992195, CD678447
    Consensus CDS
    CCDS9200.1
    UniProtKB/Swiss-Prot
    P63167
    UniProtKB/TrEMBL
    Q6FGH9
    Related
    ENSP00000376297, OTTHUMP00000240904, ENST00000392509, OTTHUMT00000403709
    Conserved Domains (1) summary
    PTZ00059
    Location:189
    Blast Score: 469
    PTZ00059; dynein light chain; Provisional
  2. NM_001037495.1NP_001032584.1  dynein light chain 1, cytoplasmic

    See proteins identical to NP_001032584.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains a distinct 5' UTR including an alternate, downstream transcription initiation site. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    BC104244, BG705617, BI491360, BM817665, BU598428, CD678447
    Consensus CDS
    CCDS9200.1
    UniProtKB/Swiss-Prot
    P63167
    UniProtKB/TrEMBL
    Q6FGH9
    Related
    ENSP00000376296, OTTHUMP00000240908, ENST00000392508, OTTHUMT00000403713
    Conserved Domains (1) summary
    PTZ00059
    Location:189
    Blast Score: 469
    PTZ00059; dynein light chain; Provisional
  3. NM_003746.2NP_003737.1  dynein light chain 1, cytoplasmic

    See proteins identical to NP_003737.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains a distinct 5' UTR, including an alternate, downstream transcription initiation site. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC063943, BG705617, BI491360, BU598428
    Consensus CDS
    CCDS9200.1
    UniProtKB/Swiss-Prot
    P63167
    UniProtKB/TrEMBL
    Q6FGH9
    Related
    ENSP00000242577, OTTHUMP00000240909, ENST00000242577, OTTHUMT00000403714
    Conserved Domains (1) summary
    PTZ00059
    Location:189
    Blast Score: 469
    PTZ00059; dynein light chain; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000012.12 

    Range
    120469857..120498495
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000144.1 

    Range
    117917550..117946088
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 

    Range
    120876465..120905100
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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