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PODXL podocalyxin-like [ Homo sapiens (human) ]

Gene ID: 5420, updated on 11-Sep-2014
Official Symbol
PODXLprovided by HGNC
Official Full Name
podocalyxin-likeprovided by HGNC
Primary source
HGNC:HGNC:9171
See related
HPRD:04025; MIM:602632
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PC; PCLP; Gp200; PCLP-1
Summary
This gene encodes a member of the sialomucin protein family. The encoded protein was originally identified as an important component of glomerular podocytes. Podocytes are highly differentiated epithelial cells with interdigitating foot processes covering the outer aspect of the glomerular basement membrane. Other biological activities of the encoded protein include: binding in a membrane protein complex with Na+/H+ exchanger regulatory factor to intracellular cytoskeletal elements, playing a role in hematopoetic cell differentiation, and being expressed in vascular endothelium cells and binding to L-selectin. [provided by RefSeq, Jul 2008]
See PODXL in Epigenomics, MapViewer
Location:
7q32-q33
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 7 NC_000007.14 (131500262..131556617, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (131185021..131241376, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene muskelin 1, intracellular mediator containing kelch motifs Neighboring gene ribosomal protein L27 pseudogene 11 Neighboring gene MKLN1 antisense RNA Neighboring gene ribosomal protein L31 pseudogene 36 Neighboring gene eukaryotic translation elongation factor 1 beta 2 pseudogene Neighboring gene ribosomal protein S14 pseudogene 10

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • MGC138240

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
 
Process Evidence Code Pubs
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
epithelial tube formation ISS
Inferred from Sequence or Structural Similarity
more info
 
glomerular visceral epithelial cell development ISS
Inferred from Sequence or Structural Similarity
more info
 
leukocyte migration IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell-cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell-cell adhesion mediated by integrin IDA
Inferred from Direct Assay
more info
PubMed 
regulation of microvillus assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
cell body IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
PubMed 
filopodium IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
membrane raft IEA
Inferred from Electronic Annotation
more info
 
microvillus membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
ruffle IDA
Inferred from Direct Assay
more info
PubMed 
slit diaphragm ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
podocalyxin
Names
podocalyxin
GCTM-2 antigen
podocalyxin-like protein 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001018111.2NP_001018121.1  podocalyxin isoform 1 precursor

    See proteins identical to NP_001018121.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK055816, AK223573, BC042466, BP355358, CN290641
    Consensus CDS
    CCDS34755.1
    UniProtKB/Swiss-Prot
    O00592
    UniProtKB/TrEMBL
    Q96N83
    Conserved Domains (1) summary
    pfam06365
    Location:358558
    CD34_antigen; CD34/Podocalyxin family
  2. NM_005397.3NP_005388.2  podocalyxin isoform 2 precursor

    See proteins identical to NP_005388.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame alternate exon compared to variant 1, resulting in a shorter protein (isoform 2).
    Source sequence(s)
    AK055816, AK223573, BC042466, BP355358
    Consensus CDS
    CCDS47714.1
    UniProtKB/Swiss-Prot
    O00592
    UniProtKB/TrEMBL
    Q96N83
    Conserved Domains (2) summary
    pfam06365
    Location:326526
    CD34_antigen; CD34/Podocalyxin family
    pfam10428
    Location:185290
    SOG2; RAM signalling pathway protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000007.14 

    Range
    131500262..131556617
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000139.1 

    Range
    125500684..125557022
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018918.2 

    Range
    131118904..131175753
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)