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    Bag1 BCL2-associated athanogene 1 [ Mus musculus (house mouse) ]

    Gene ID: 12017, updated on 8-Aug-2016
    Official Symbol
    Bag1provided by MGI
    Official Full Name
    BCL2-associated athanogene 1provided by MGI
    Primary source
    MGI:MGI:108047
    See related
    Ensembl:ENSMUSG00000028416 Vega:OTTMUSG00000006605
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BAG-1; Rap46
    Summary
    The oncogene Bcl2 encodes a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to Bcl2 protein and is referred to as Bcl2-associated athanogene. It enhances the anti-apoptotic effects of Bcl2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. At least two protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) start site and an alternative, downstream, AUG translation initiation site. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    4; 4 B1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (40936398..40948294, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (40883431..40895327, complement)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene lysine (K)-specific demethylase 2B pseudogene Neighboring gene serine peptidase inhibitor, Kazal type 4 Neighboring gene charged multivesicular body protein 5 Neighboring gene nuclear transcription factor, X-box binding 1 Neighboring gene microRNA 3094

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    chaperone binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphoprotein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    BAG family molecular chaperone regulator 1
    Names
    Bcl-2-binding protein
    bcl-2-associated athanogene 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001171739.1NP_001165210.1  BAG family molecular chaperone regulator 1 isoform 1S

      See identical proteins and their annotated locations for NP_001165210.1

      Status: REVIEWED

      Description
      Transcript Variant: This transcript (1) encodes multiple isoforms due to the use of alternative translation initiation codons. The longer isoform (BAG-1L or p50) is derived from an upstream non-AUG (CUG) start codon, while the shorter isoform (BAG-1S or p32) is derived from a downstream AUG start codon. The shorter isoform (1S) is represented in this RefSeq.
      Source sequence(s)
      AK009149, AK013611, BQ031093, CX225744
      Consensus CDS
      CCDS51139.1
      UniProtKB/Swiss-Prot
      Q60739
      UniProtKB/TrEMBL
      Q9CUY1
      Related
      ENSMUSP00000139864, ENSMUST00000191273
      Conserved Domains (3) summary
      smart00213
      Location:2194
      UBQ; Ubiquitin homologues
      smart00264
      Location:133200
      BAG; BAG domains, present in regulator of Hsp70 proteins
      cl00155
      Location:1894
      UBQ; Ubiquitin-like proteins
    2. NM_009736.3NP_033866.4  BAG family molecular chaperone regulator 1 isoform 1L

      See identical proteins and their annotated locations for NP_033866.4

      Status: REVIEWED

      Description
      Transcript Variant: This transcript (1) encodes multiple isoforms due to the use of alternative translation initiation codons. The longer isoform (BAG-1L or p50) is derived from an upstream non-AUG (CUG) start codon, while the shorter isoform (BAG-1S or p32) is derived from a downstream AUG start codon. The longer isoform (1L) is represented in this RefSeq.
      Source sequence(s)
      AK009149, AK013611, BQ031093, CX225744
      Consensus CDS
      CCDS38713.1
      UniProtKB/Swiss-Prot
      Q60739
      UniProtKB/TrEMBL
      Q9CUY1
      Related
      ENSMUSP00000030125, OTTMUSP00000048886, ENSMUST00000030125, OTTMUST00000089455
      Conserved Domains (3) summary
      smart00213
      Location:157230
      UBQ; Ubiquitin homologues
      smart00264
      Location:269336
      BAG; BAG domains, present in regulator of Hsp70 proteins
      cl00155
      Location:154230
      UBQ; Ubiquitin-like proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      40936398..40948294 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)