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Creb1 cAMP responsive element binding protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 81646, updated on 9-Dec-2014
Official Symbol
Creb1provided by RGD
Official Full Name
cAMP responsive element binding protein 1provided by RGD
Primary source
RGD:620218
See related
Ensembl:ENSRNOG00000013412
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
Creb
Summary
binds the cAMP response element in many gene promoters and regulates transcription [RGD, Feb 2006]
See Creb1 in MapViewer
Location:
9q32
Exon count:
13
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (71229799..71298994)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 9 NC_005108.3 (71277171..71346198, complement)

Chromosome 9 - NC_005108.4Genomic Context describing neighboring genes Neighboring gene high mobility group protein HMG-I/HMG-Y-like Neighboring gene small integral membrane protein 7-like Neighboring gene protein N-lysine methyltransferase METTL21A-like Neighboring gene uncharacterized LOC102556685

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II activating transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II core promoter proximal region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II distal enhancer sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription ISO
Inferred from Sequence Orthology
more info
 
cAMP response element binding ISO
Inferred from Sequence Orthology
more info
 
double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
histone acetyltransferase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
sequence-specific DNA binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription regulatory region DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
Type I pneumocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
axonogenesis ISO
Inferred from Sequence Orthology
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cellular response to growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to zinc ion ISO
Inferred from Sequence Orthology
more info
 
circadian rhythm IEP
Inferred from Expression Pattern
more info
PubMed 
circadian rhythm ISO
Inferred from Sequence Orthology
more info
 
lactation ISO
Inferred from Sequence Orthology
more info
 
lung epithelium development ISO
Inferred from Sequence Orthology
more info
 
lung saccule development ISO
Inferred from Sequence Orthology
more info
 
mammary gland development ISO
Inferred from Sequence Orthology
more info
 
memory ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription by competitive promoter binding ISO
Inferred from Sequence Orthology
more info
 
pituitary gland development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of RNA polymerase II transcriptional preinitiation complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of hormone secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of lipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of lipid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of multicellular organism growth ISO
Inferred from Sequence Orthology
more info
 
positive regulation of osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transforming growth factor beta3 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein stabilization ISO
Inferred from Sequence Orthology
more info
 
protein stabilization ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell size ISO
Inferred from Sequence Orthology
more info
 
regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
response to drug ISO
Inferred from Sequence Orthology
more info
 
response to glucagon ISO
Inferred from Sequence Orthology
more info
 
response to glucagon ISS
Inferred from Sequence or Structural Similarity
more info
 
response to organic substance ISO
Inferred from Sequence Orthology
more info
 
secretory granule organization ISO
Inferred from Sequence Orthology
more info
 
transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
chromatin IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
nuclear chromatin IDA
Inferred from Direct Assay
more info
PubMed 
nuclear chromatin ISO
Inferred from Sequence Orthology
more info
 
nuclear euchromatin ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 
transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
cyclic AMP-responsive element-binding protein 1
Names
cyclic AMP-responsive element-binding protein 1
CREB-1
Y protein
cAMP response element binding protein 1
cAMP-responsive element-binding protein 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031017.1NP_112279.1  cyclic AMP-responsive element-binding protein 1 isoform B

    See proteins identical to NP_112279.1

    Status: PROVISIONAL

    Source sequence(s)
    X14788
    UniProtKB/Swiss-Prot
    P15337
    Conserved Domains (2) summary
    pfam02173
    Location:113151
    pKID; pKID domain
    cd12193
    Location:285337
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins
  2. NM_134443.1NP_604392.1  cyclic AMP-responsive element-binding protein 1 isoform A

    See proteins identical to NP_604392.1

    Status: PROVISIONAL

    Source sequence(s)
    X60002
    UniProtKB/Swiss-Prot
    P15337
    Conserved Domains (2) summary
    pfam02173
    Location:99137
    pKID; pKID domain
    cd12193
    Location:271323
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005108.4 

    Range
    71229799..71298994
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006245065.2XP_006245127.1  

    See proteins identical to XP_006245127.1

    UniProtKB/Swiss-Prot
    P15337
    Related
    ENSRNOP00000018326
    Conserved Domains (2) summary
    pfam02173
    Location:113151
    pKID; pKID domain
    cd12193
    Location:285337
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins
  2. XM_006245066.2XP_006245128.1  

    See proteins identical to XP_006245128.1

    UniProtKB/Swiss-Prot
    P15337
    Related
    ENSRNOP00000049369
    Conserved Domains (2) summary
    pfam02173
    Location:99137
    pKID; pKID domain
    cd12193
    Location:271323
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins
  3. XM_006245067.2XP_006245129.1  

    See proteins identical to XP_006245129.1

    Conserved Domains (2) summary
    pfam02173
    Location:73111
    pKID; pKID domain
    cd12193
    Location:245297
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins
  4. XM_006245068.2XP_006245130.1  

    See proteins identical to XP_006245130.1

    Conserved Domains (2) summary
    pfam02173
    Location:1553
    pKID; pKID domain
    cd12193
    Location:187239
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins
  5. XM_008767138.1XP_008765360.1  

    See proteins identical to XP_008765360.1

    Conserved Domains (2) summary
    pfam02173
    Location:1553
    pKID; pKID domain
    cd12193
    Location:187239
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins
  6. XM_006245069.2XP_006245131.1  

    See proteins identical to XP_006245131.1

    Conserved Domains (2) summary
    pfam02173
    Location:1553
    pKID; pKID domain
    cd12193
    Location:187239
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins
  7. XM_006245070.2XP_006245132.1  

    See proteins identical to XP_006245132.1

    Conserved Domains (1) summary
    cd12193
    Location:55107
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins
  8. XM_008767139.1XP_008765361.1  

    See proteins identical to XP_008765361.1

    Conserved Domains (1) summary
    cd12193
    Location:55107
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins

Alternate Rn_Celera

Genomic

  1. AC_000077.1 

    Range
    63310784..63374139
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)