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    TNFAIP6 tumor necrosis factor, alpha-induced protein 6 [ Homo sapiens (human) ]

    Gene ID: 7130, updated on 5-Jul-2015
    Official Symbol
    TNFAIP6provided by HGNC
    Official Full Name
    tumor necrosis factor, alpha-induced protein 6provided by HGNC
    Primary source
    HGNC:HGNC:11898
    See related
    Ensembl:ENSG00000123610; HPRD:02680; MIM:600410; Vega:OTTHUMG00000131884
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TSG6; TSG-6
    Summary
    The protein encoded by this gene is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable complex with inter-alpha-inhibitor (I alpha I), and thus enhance the serine protease inhibitory activity of I alpha I, which is important in the protease network associated with inflammation. This gene can be induced by proinflammatory cytokines such as tumor necrosis factor alpha and interleukin-1. Enhanced levels of this protein are found in the synovial fluid of patients with osteoarthritis and rheumatoid arthritis.[provided by RefSeq, Dec 2010]
    Orthologs
    See TNFAIP6 in Epigenomics, MapViewer
    Location:
    2q23.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 2 NC_000002.12 (151357583..151381245)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (152214106..152236562)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373687 Neighboring gene N-myc (and STAT) interactor Neighboring gene uncharacterized LOC101929319 Neighboring gene microRNA 4773-1 Neighboring gene microRNA 4773-2 Neighboring gene replication timing regulatory factor 1 Neighboring gene nebulin Neighboring gene uncharacterized LOC101929356

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of tumor necrosis factor, alpha-induced protein 6 (TNFAIP6) in human B cells PubMed
    Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of tumor necrosis factor, alpha-induced protein 6 (TNFAIP6) in primary human brain microvascular endothelial cells PubMed
    tat HIV-1 and the viral protein Tat modulate the expression of tumor necrosis factor, alpha-induced protein 6 (TNFAIP6) in immature dendritic cells and monocyte-derived macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    hyaluronic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cell-cell signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    inflammatory response TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of inflammatory response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Preferred Names
    tumor necrosis factor-inducible gene 6 protein
    Names
    TNF alpha-induced protein 6
    TNF-stimulated gene 6 protein
    hyaluronate-binding protein
    tumor necrosis factor alpha-inducible protein 6
    tumor necrosis factor-stimulated gene-6 protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007115.3NP_009046.2  tumor necrosis factor-inducible gene 6 protein precursor

      See identical proteins and their annotated locations for NP_009046.2

      Status: REVIEWED

      Source sequence(s)
      AC009311, AU102580, BC030205, CA307541
      Consensus CDS
      CCDS2193.1
      UniProtKB/Swiss-Prot
      P98066
      Related
      ENSP00000243347, OTTHUMP00000162710, ENST00000243347, OTTHUMT00000254834
      Conserved Domains (2) summary
      cd00041
      Location:135246
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd03515
      Location:36128
      Link_domain_TSG_6_like; This is the extracellular link domain of the type found in human TSG-6. The link domain is a hyaluronan (HA)-binding domain. TSG-6 is the protein product of tumor necrosis factor-stimulated gene-6. TSG-6 is up-regulated in inflammatory lesions and in the ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p2 Primary Assembly

      Range
      151357583..151381245
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011511710.1XP_011510012.1  

      Conserved Domains (2) summary
      cd00041
      Location:135224
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd03515
      Location:36128
      Link_domain_TSG_6_like; This is the extracellular link domain of the type found in human TSG-6. The link domain is a hyaluronan (HA)-binding domain. TSG-6 is the protein product of tumor necrosis factor-stimulated gene-6. TSG-6 is up-regulated in inflammatory lesions and in the ...

    Alternate CHM1_1.1

    Genomic

    1. NC_018913.2 Alternate CHM1_1.1

      Range
      152219924..152242420
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)