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Eps15 epidermal growth factor receptor pathway substrate 15 [ Mus musculus (house mouse) ]

Gene ID: 13858, updated on 26-Aug-2014
Official Symbol
Eps15provided by MGI
Official Full Name
epidermal growth factor receptor pathway substrate 15provided by MGI
Primary source
MGI:104583
Locus tag
RP23-414M10.3
See related
Ensembl:ENSMUSG00000028552; Vega:OTTMUSG00000008289
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2410112D09Rik
See Eps15 in Epigenomics, MapViewer
Location:
4 C7; 4
Exon count:
25
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 4 NC_000070.6 (109280028..109387817)

Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102635178 Neighboring gene oxysterol binding protein-like 9 Neighboring gene calreticulin 4 Neighboring gene basic leucine zipper and W2 domains 1 pseudogene Neighboring gene uncharacterized LOC102635290 Neighboring gene tetratricopeptide repeat domain 39A Neighboring gene ring finger protein 11

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
polyubiquitin binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Golgi to endosome transport ISO
Inferred from Sequence Orthology
more info
 
clathrin coat assembly ISO
Inferred from Sequence Orthology
more info
 
endocytosis IEA
Inferred from Electronic Annotation
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
AP-2 adaptor complex IDA
Inferred from Direct Assay
more info
PubMed 
ciliary membrane IDA
Inferred from Direct Assay
more info
 
clathrin coat of coated pit IDA
Inferred from Direct Assay
more info
PubMed 
clathrin-coated vesicle IDA
Inferred from Direct Assay
more info
PubMed 
coated pit IDA
Inferred from Direct Assay
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
endosome IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
epidermal growth factor receptor substrate 15
Names
epidermal growth factor receptor substrate 15
protein AF-1p
epidermal growth factor pathway substrate 15

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159964.1NP_001153436.1  epidermal growth factor receptor substrate 15 isoform B

    See proteins identical to NP_001153436.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks multiple exons at the 5' end and has a distinct 5' UTR and start codon, compared to variant 1. These differences result in a protein (isoform B) with a shorter and distinct N-terminus, compared to isoform A. Isoform B localizes to early endosome membranes.
    Source sequence(s)
    AK083176, AW124983, BC048783, CF533628
    Consensus CDS
    CCDS51259.1
    UniProtKB/Swiss-Prot
    P42567
    UniProtKB/TrEMBL
    Q80ZL3
    Conserved Domains (3) summary
    pfam07926
    Location:32169
    Blast Score: 94
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam15272
    Location:29225
    Blast Score: 85
    BBP1_C; Spindle pole body component BBP1, C-terminal
    cl19219
    Location:86160
    Blast Score: 110
    DUF342; Protein of unknown function (DUF342)
  2. NM_007943.3NP_031969.1  epidermal growth factor receptor substrate 15 isoform A

    See proteins identical to NP_031969.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (A). Isoform A mainly localizes to clathrin-coated pits at the plasma membrane.
    Source sequence(s)
    AK083176, AW124983, BB858255, BC048783
    Consensus CDS
    CCDS18462.1
    UniProtKB/Swiss-Prot
    P42567
    UniProtKB/TrEMBL
    Q80ZL3
    Related
    ENSMUSP00000099790, OTTMUSP00000008654, ENSMUST00000102729, OTTMUST00000018848
    Conserved Domains (5) summary
    smart00027
    Location:121215
    Blast Score: 382
    EH; Eps15 homology domain
    cd00052
    Location:228293
    Blast Score: 248
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam07926
    Location:345483
    Blast Score: 105
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam12329
    Location:397465
    Blast Score: 103
    TMF_DNA_bd; TATA element modulatory factor 1 DNA binding
    cl19113
    Location:327506
    Blast Score: 96
    ApoLp-III_like; Apolipophorin-III and similar insect proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000070.6 

    Range
    109280028..109387817
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502738.1XP_006502801.1  

    Conserved Domains (5) summary
    smart00027
    Location:249343
    Blast Score: 386
    EH; Eps15 homology domain
    cd00052
    Location:392457
    Blast Score: 253
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam07926
    Location:509647
    Blast Score: 113
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam12329
    Location:561629
    Blast Score: 110
    TMF_DNA_bd; TATA element modulatory factor 1 DNA binding
    cl19113
    Location:491670
    Blast Score: 103
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  2. XM_006502740.1XP_006502803.1  

    Conserved Domains (5) summary
    smart00027
    Location:249343
    Blast Score: 389
    EH; Eps15 homology domain
    cd00052
    Location:392457
    Blast Score: 254
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam07926
    Location:509647
    Blast Score: 114
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam12329
    Location:561629
    Blast Score: 112
    TMF_DNA_bd; TATA element modulatory factor 1 DNA binding
    cl19113
    Location:491670
    Blast Score: 103
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  3. XM_006502739.1XP_006502802.1  

    Conserved Domains (5) summary
    smart00027
    Location:217311
    Blast Score: 386
    EH; Eps15 homology domain
    cd00052
    Location:360425
    Blast Score: 253
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam07926
    Location:477615
    Blast Score: 112
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam12329
    Location:529597
    Blast Score: 109
    TMF_DNA_bd; TATA element modulatory factor 1 DNA binding
    cl19113
    Location:459638
    Blast Score: 102
    ApoLp-III_like; Apolipophorin-III and similar insect proteins

Alternate Mm_Celera

Genomic

  1. AC_000026.1 

    Range
    107626627..107727939
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)