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    Polr2a polymerase (RNA) II (DNA directed) polypeptide A [ Mus musculus (house mouse) ]

    Gene ID: 20020, updated on 24-Jun-2016
    Official Symbol
    Polr2aprovided by MGI
    Official Full Name
    polymerase (RNA) II (DNA directed) polypeptide Aprovided by MGI
    Primary source
    MGI:MGI:98086
    See related
    Ensembl:ENSMUSG00000005198 Vega:OTTMUSG00000006003
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rpb1; 220kDa; Rpo2-1
    Orthologs
    Location:
    11 42.86 cM; 11 B1-C
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (69733997..69758633, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (69547912..69571725, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene tumor necrosis factor (ligand) superfamily, member 13, opposite strand Neighboring gene tumor necrosis factor (ligand) superfamily, membrane-bound member 13 Neighboring gene tumor necrosis factor (ligand) superfamily, member 13 Neighboring gene tumor necrosis factor (ligand) superfamily, member 12 Neighboring gene solute carrier family 35, member G3 Neighboring gene zinc finger and BTB domain containing 4

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    • Homologs of the Polr2a gene: The Polr2a gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
    • Orthologs from Annotation Pipeline: 137 organisms have orthologs with human gene Polr2a
    • Map Viewer (Human, Rat)

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA-directed RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to RNA polymerase II activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    core promoter binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    poly(A) RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    DNA-templated transcription, termination ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of RNA splicing ISO
    Inferred from Sequence Orthology
    more info
     
    transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    DNA-directed RNA polymerase II, core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    DNA-directed RNA polymerase II, core complex ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with Prp19 complex ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear euchromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT nucleolus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Preferred Names
    DNA-directed RNA polymerase II subunit RPB1
    Names
    DNA-directed RNA polymerase II subunit A
    DNA-directed RNA polymerase III largest subunit
    RNA polymerase II 1
    RNA polymerase II subunit B1
    NP_001277997.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291068.1NP_001277997.1  DNA-directed RNA polymerase II subunit RPB1

      See identical proteins and their annotated locations for NP_001277997.1

      Status: VALIDATED

      Source sequence(s)
      AL603707
      Consensus CDS
      CCDS70217.1
      UniProtKB/Swiss-Prot
      P08775
      Related
      ENSMUSP00000050771, OTTMUSP00000006224, ENSMUST00000058470, OTTMUST00000013440
      Conserved Domains (7) summary
      cd02584
      Location:10581476
      RNAP_II_Rpb1_C; Largest subunit (Rpb1) of Eukaryotic RNA polymerase II (RNAP II), C-terminal domain
      pfam04998
      Location:8301428
      RNA_pol_Rpb1_5; RNA polymerase Rpb1, domain 5
      smart01104
      Location:14911610
      CTD; Spt5 C-terminal nonapeptide repeat binding Spt4
      PRK08566
      Location:18895
      PRK08566; DNA-directed RNA polymerase subunit A'; Validated
      pfam04992
      Location:8961079
      RNA_pol_Rpb1_6; RNA polymerase Rpb1, domain 6
      pfam10428
      Location:18611970
      SOG2; RAM signalling pathway protein
      cd02733
      Location:19876
      RNAP_II_RPB1_N; Largest subunit (Rpb1) of eukaryotic RNA polymerase II (RNAP II), N-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      69733997..69758633 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_009089.2: Suppressed sequence

      Description
      NM_009089.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.