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    CWC22 CWC22 spliceosome-associated protein [ Homo sapiens (human) ]

    Gene ID: 57703, updated on 5-Jul-2015
    Official Symbol
    CWC22provided by HGNC
    Official Full Name
    CWC22 spliceosome-associated proteinprovided by HGNC
    Primary source
    HGNC:HGNC:29322
    See related
    Ensembl:ENSG00000163510; HPRD:17220; MIM:615186; Vega:OTTHUMG00000154244
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NCM; fSAPb; EIF4GL
    Orthologs
    See CWC22 in Epigenomics, MapViewer
    Location:
    2q31.3
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 2 NC_000002.12 (179944876..180007297, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (180809603..180872024, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene zinc finger protein 385B Neighboring gene thioredoxin-like 4A pseudogene Neighboring gene microRNA 1258 Neighboring gene uncharacterized LOC105373767 Neighboring gene uncharacterized LOC105373768

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.
    NHGRI GWA Catalog
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • KIAA1604

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    PubMed 
    regulation of mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    catalytic step 2 spliceosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
     
    nuclear speck IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    pre-mRNA-splicing factor CWC22 homolog
    Names
    CWC22 spliceosome-associated protein homolog
    functional spliceosome-associated protein b
    nucampholin homolog

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020943.2NP_065994.1  pre-mRNA-splicing factor CWC22 homolog

      See identical proteins and their annotated locations for NP_065994.1

      Status: VALIDATED

      Source sequence(s)
      AB046824, BC031216
      Consensus CDS
      CCDS46465.1
      UniProtKB/Swiss-Prot
      Q9HCG8
      Related
      ENSP00000387006, OTTHUMP00000205374, ENST00000410053, OTTHUMT00000334537
      Conserved Domains (3) summary
      smart00544
      Location:455561
      MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
      pfam02854
      Location:164345
      MIF4G; MIF4G domain
      pfam15101
      Location:718767
      DUF4557; Domain of unknown function (DUF4557)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p2 Primary Assembly

      Range
      179944876..180007297
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005246726.1XP_005246783.1  

      See identical proteins and their annotated locations for XP_005246783.1

      UniProtKB/Swiss-Prot
      Q9HCG8
      Conserved Domains (3) summary
      smart00544
      Location:455561
      MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
      pfam02854
      Location:164345
      MIF4G; MIF4G domain
      pfam15101
      Location:718767
      DUF4557; Domain of unknown function (DUF4557)

    Alternate CHM1_1.1

    Genomic

    1. NC_018913.2 Alternate CHM1_1.1

      Range
      180815566..180877744
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)