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ZNF644 zinc finger protein 644 [ Homo sapiens (human) ]

Gene ID: 84146, updated on 7-Dec-2014
Official Symbol
ZNF644provided by HGNC
Official Full Name
zinc finger protein 644provided by HGNC
Primary source
HGNC:HGNC:29222
See related
Ensembl:ENSG00000122482; HPRD:15885; MIM:614159; Vega:OTTHUMG00000010078
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NatF; MYP21; ZEP-2; BM-005
Summary
The protein encoded by this gene is a zinc finger transcription factor that may play a role in eye development. Defects in this gene have been associated with high myopia. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
See ZNF644 in Epigenomics, MapViewer
Location:
1p22.2
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 1 NC_000001.11 (90915298..91022255, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (91380855..91487812, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC149351 Neighboring gene phosphorylase kinase, alpha 1 pseudogene 1 Neighboring gene uncharacterized LOC102723410 Neighboring gene ribosomal protein L5 pseudogene 6 Neighboring gene HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae) Neighboring gene flap structure-specific endonuclease 1 pseudogene 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Myopia 21, autosomal dominant
MedGen: C3279997 OMIM: 614167 GeneReviews: Not available
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NHGRI GWAS Catalog

Description
A genome-wide association study of the metabolic syndrome in Indian Asian men.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA1221, MGC60165, MGC70410

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
zinc finger protein 644
Names
zinc finger protein 644
zinc finger motif enhancer binding protein 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029760.1 

    Range
    5001..111958
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_016620.3NP_057704.2  zinc finger protein 644 isoform 2

    See proteins identical to NP_057704.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks two alternate in-frame exons compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Variants 2 and 3 both encode isoform 2.
    Source sequence(s)
    AB033047, BX477299, DA147194
    Consensus CDS
    CCDS732.1
    UniProtKB/Swiss-Prot
    Q9H582
    Related
    ENSP00000340828, OTTHUMP00000011765, ENST00000347275, OTTHUMT00000027847
  2. NM_032186.4NP_115562.3  zinc finger protein 644 isoform 2

    See proteins identical to NP_115562.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Variants 2 and 3 both encode isoform 2.
    Source sequence(s)
    AB033047, BI760689, BX477299, DB001551
    Consensus CDS
    CCDS732.1
    UniProtKB/Swiss-Prot
    Q9H582
  3. NM_201269.2NP_958357.1  zinc finger protein 644 isoform 1

    See proteins identical to NP_958357.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC132776, BC150177, BX477299, DB001551
    Consensus CDS
    CCDS731.1
    UniProtKB/TrEMBL
    A7E234
    UniProtKB/Swiss-Prot
    Q9H582
    Related
    ENSP00000337008, ENST00000337393
    Conserved Domains (1) summary
    cl19114
    Location:438501
    RNAP_largest_subunit_N; Largest subunit of RNA polymerase (RNAP), N-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000001.11 

    Range
    90915298..91022255
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006710947.1XP_006711010.1  

    See proteins identical to XP_006711010.1

    UniProtKB/Swiss-Prot
    Q9H582
  2. XM_005271257.2XP_005271314.1  

    See proteins identical to XP_005271314.1

    Conserved Domains (1) summary
    cl19114
    Location:438501
    RNAP_largest_subunit_N; Largest subunit of RNA polymerase (RNAP), N-terminal domain
  3. XM_006710948.1XP_006711011.1  

    See proteins identical to XP_006711011.1

    UniProtKB/Swiss-Prot
    Q9H582
  4. XM_005271260.2XP_005271317.1  

    See proteins identical to XP_005271317.1

    Conserved Domains (1) summary
    cl19114
    Location:438501
    RNAP_largest_subunit_N; Largest subunit of RNA polymerase (RNAP), N-terminal domain
  5. XM_005271261.2XP_005271318.1  

    See proteins identical to XP_005271318.1

    UniProtKB/Swiss-Prot
    Q9H582
    Conserved Domains (1) summary
    cl19114
    Location:438501
    RNAP_largest_subunit_N; Largest subunit of RNA polymerase (RNAP), N-terminal domain

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 

    Range
    91496050..91602984
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000133.1 

    Range
    89499857..89606862
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)