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    Hif3a hypoxia inducible factor 3, alpha subunit [ Mus musculus (house mouse) ]

    Gene ID: 53417, updated on 29-Mar-2016
    Official Symbol
    Hif3aprovided by MGI
    Official Full Name
    hypoxia inducible factor 3, alpha subunitprovided by MGI
    Primary source
    MGI:MGI:1859778
    See related
    Ensembl:ENSMUSG00000004328 Vega:OTTMUSG00000022817
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ipas; MOP7; NEPAS; bHLHe17
    Orthologs
    Location:
    7; 7 A2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 7 NC_000073.6 (17030993..17062427, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (17616342..17647776, complement)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 8 Neighboring gene protein phosphatase 5, catalytic subunit Neighboring gene predicted gene, 35698 Neighboring gene pregnancy specific glycoprotein 16 Neighboring gene ribosomal protein L15 pseudogene

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor activity, sequence-specific DNA binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription factor activity, sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of nucleic acid-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    response to hypoxia IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription from RNA polymerase II promoter IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear speck IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IC
    Inferred by Curator
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    hypoxia-inducible factor 3-alpha
    Names
    HIF-3-alpha
    HIF3-alpha
    HIF3-alpha-1
    basic-helix-loop-helix-PAS protein MOP7
    hypoxia inducible factor three alpha
    inhibitory PAS domain protein
    member of PAS protein 7
    neonatal and embryonic PAS protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162950.1NP_001156422.1  hypoxia-inducible factor 3-alpha isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC148976
      Consensus CDS
      CCDS52045.1
      UniProtKB/Swiss-Prot
      Q0VBL6
      Related
      ENSMUSP00000104132, OTTMUSP00000026203, ENSMUST00000108492, OTTMUST00000054840
      Conserved Domains (4) summary
      pfam11413
      Location:474507
      HIF-1; Hypoxia-inducible factor-1
      cd00083
      Location:1368
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:241338
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam14598
      Location:241342
      PAS_11; PAS domain
    2. NM_016868.3NP_058564.2  hypoxia-inducible factor 3-alpha isoform 2

      See identical proteins and their annotated locations for NP_058564.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC148976
      Consensus CDS
      CCDS20860.1
      UniProtKB/Swiss-Prot
      Q0VBL6
      Related
      ENSMUSP00000048248, OTTMUSP00000026202, ENSMUST00000037762, OTTMUST00000054839
      Conserved Domains (4) summary
      pfam11413
      Location:472505
      HIF-1; Hypoxia-inducible factor-1
      cd00083
      Location:1166
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      cd00130
      Location:239336
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam14598
      Location:239340
      PAS_11; PAS domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p3 C57BL/6J

      Range
      17030993..17062427 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011250628.1XP_011248930.1  

      Conserved Domains (3) summary
      pfam11413
      Location:418451
      HIF-1; Hypoxia-inducible factor-1
      cd00130
      Location:185282
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam14598
      Location:185286
      PAS_11; PAS domain

    Alternate Mm_Celera

    Genomic

    1. AC_000029.1 Alternate Mm_Celera

      Range
      14238445..14270033 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    2. NW_001036012.1 Alternate Mm_Celera

      Range
      597..2071 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)