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Hcls1 hematopoietic cell specific Lyn substrate 1 [ Mus musculus (house mouse) ]

Gene ID: 15163, updated on 19-Sep-2014
Official Symbol
Hcls1provided by MGI
Official Full Name
hematopoietic cell specific Lyn substrate 1provided by MGI
Primary source
MGI:MGI:104568
See related
Ensembl:ENSMUSG00000022831; Vega:OTTMUSG00000035773
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HS1; AW213261
See Hcls1 in Epigenomics, MapViewer
Location:
16; 16 B
Exon count:
14
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 16 NC_000082.6 (36934983..36963214)

Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene ELL associated factor 2 Neighboring gene IQ calmodulin-binding motif containing 1 Neighboring gene RIKEN cDNA 4930565N06 gene Neighboring gene golgi autoantigen, golgin subfamily b, macrogolgin 1 Neighboring gene F-box protein 40 Neighboring gene polymerase (DNA directed), theta

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
    B Cell Receptor Signaling Pathway, organism-specific biosystemThe B cell receptor includes membrane ???? heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation...
  • Bacterial invasion of epithelial cells, organism-specific biosystem (from KEGG)
    Bacterial invasion of epithelial cells, organism-specific biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
  • Bacterial invasion of epithelial cells, conserved biosystem (from KEGG)
    Bacterial invasion of epithelial cells, conserved biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
  • IL-5 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-5 Signaling Pathway, organism-specific biosystem
    IL-5 Signaling Pathway
  • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
    Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • Proteoglycans in cancer, conserved biosystem (from KEGG)
    Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • Tight junction, organism-specific biosystem (from KEGG)
    Tight junction, organism-specific biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
  • Tight junction, conserved biosystem (from KEGG)
    Tight junction, conserved biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
  • XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
    XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
RNA polymerase II transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
SH3 domain binding IDA
Inferred from Direct Assay
more info
PubMed 
SH3 domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
actin binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
actin filament polymerization IEA
Inferred from Electronic Annotation
more info
 
cellular response to cytokine stimulus ISO
Inferred from Sequence Orthology
more info
 
erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of leukocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of granulocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 
positive regulation of granulocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of macrophage differentiation IMP
Inferred from Mutant Phenotype
more info
 
positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription factor import into nucleus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of tyrosine phosphorylation of STAT protein IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
 
response to hormone IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
transcription factor complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
hematopoietic lineage cell-specific protein
Names
hematopoietic lineage cell-specific protein
lckBP1
hematopoietic cell-specific LYN substrate 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008225.2NP_032251.2  hematopoietic lineage cell-specific protein

    See proteins identical to NP_032251.2

    Status: VALIDATED

    Source sequence(s)
    AC154763, AK040049, BX519502, CA321698
    Consensus CDS
    CCDS37336.1
    UniProtKB/Swiss-Prot
    P49710
    UniProtKB/TrEMBL
    Q8CA06
    Related
    ENSMUSP00000023531, OTTMUSP00000050431, ENSMUST00000023531, OTTMUST00000091538
    Conserved Domains (2) summary
    pfam02218
    Location:119154
    HS1_rep; Repeat in HS1/Cortactin
    cl17036
    Location:437485
    SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000082.6 

    Range
    36934983..36963214
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000038.1 

    Range
    37345885..37374104
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)