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Ece2 endothelin converting enzyme 2 [ Mus musculus (house mouse) ]

Gene ID: 107522, updated on 26-Aug-2014
Official Symbol
Ece2provided by MGI
Official Full Name
endothelin converting enzyme 2provided by MGI
Primary source
MGI:1101356
See related
Ensembl:ENSMUSG00000022842; Vega:OTTMUSG00000028772
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BB127715; 1810009K13Rik; 6330509A19Rik; 9630025D12Rik
See Ece2 in Epigenomics, MapViewer
Location:
16 B1; 16
Exon count:
23
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 16 NC_000082.6 (20611601..20646480)

Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene von Willebrand factor A domain containing 5B2 Neighboring gene microRNA 1224 Neighboring gene asparagine-linked glycosylation 3 (alpha-1,3-mannosyltransferase) Neighboring gene calcium/calmodulin-dependent protein kinase II inhibitor 2 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 Neighboring gene eukaryotic translation elongation factor 1 gamma pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Clone Names

  • MGC144385, MGC144386

Gene Ontology Provided by MGI

Function Evidence Code Pubs
1-hydroxy-6-methoxypyrene methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
1-hydroxypyrene methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
1-phenanthrol methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
2-phytyl-1,4-naphthoquinone methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
4,5-dihydroxybenzo(a)pyrene methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
C-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
DNA-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
N-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
O-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
P-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
RNA methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
S-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
Se-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
arginine N-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
cobalt-precorrin-3 C17-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
cobalt-precorrin-5B C1-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
cobalt-precorrin-6B C5-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
cobalt-precorrin-7 C15-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
demethylmenaquinone methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
dimethylamine methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
dimethylarsinite methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
hydroxyneurosporene-O-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
lysine N-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
mRNA methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
metalloendopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
methanol-specific methylcobalamin:coenzyme M methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
methylamine-specific methylcobalamin:coenzyme M methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
methylarsonite methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
monomethylamine methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
peptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
phosphomethylethanolamine N-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
protein C-terminal carboxyl O-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
protein C-terminal leucine carboxyl O-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
protein methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
protein-arginine N-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
protein-arginine N5-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
protein-lysine N-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
rRNA (adenine) methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
rRNA (adenine-N6,N6-)-dimethyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
rRNA (adenine-N6-)-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
rRNA (cytosine) methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
rRNA (cytosine-2'-O-)-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
rRNA (cytosine-C5-)-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
rRNA (cytosine-N4-)-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
rRNA (guanine) methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
rRNA (uridine) methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
rRNA (uridine-2'-O-)-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
rRNA methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
selenocysteine methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
tRNA (adenine) methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
tRNA (adenine-57, 58-N(1)-) methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
tRNA (adenine-N1-)-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
tRNA (cytosine) methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
tRNA (cytosine-2'-O-)-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
tRNA (cytosine-3-)-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
tRNA (cytosine-5-)-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
tRNA (guanine) methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
tRNA (guanine-N1-)-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
tRNA (guanine-N2-)-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
tRNA (uracil) methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
tRNA (uracil-2'-O-)-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
tRNA methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
trihydroxyferuloyl spermidine O-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
trimethylamine methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
metabolic process IEA
Inferred from Electronic Annotation
more info
 
methylation IEA
Inferred from Electronic Annotation
more info
 
peptide hormone processing ISO
Inferred from Sequence Orthology
more info
 
peptide hormone processing ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
proteolysis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
trans-Golgi network ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Preferred Names
endothelin-converting enzyme 2
Names
endothelin-converting enzyme 2
ECE-2
NP_079738.2
NP_647454.2
NP_808809.1
NP_808810.1
NP_808811.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025462.2NP_079738.2  endothelin-converting enzyme 2 isoform c

    See proteins identical to NP_079738.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and CDS compared to variant 1. The resulting isoform (c) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    BC115541, BE956299
    Consensus CDS
    CCDS37290.1
    UniProtKB/Swiss-Prot
    Q80Z60
    Related
    ENSMUSP00000111184, OTTMUSP00000036481, ENSMUST00000115522, OTTMUST00000071265
    Conserved Domains (2) summary
    cd02440
    Location:61172
    Blast Score: 156
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    pfam13847
    Location:61172
    Blast Score: 131
    Methyltransf_31; Methyltransferase domain
  2. NM_139293.2NP_647454.2  endothelin-converting enzyme 2 isoform d

    See proteins identical to NP_647454.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and CDS compared to variant 1. The resulting isoform (d) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC087898, AF489572, AU080537
    Consensus CDS
    CCDS28052.1
    UniProtKB/TrEMBL
    B2RQR8
    UniProtKB/TrEMBL
    Q80Z57
    Related
    ENSMUSP00000003898, OTTMUSP00000036483, ENSMUST00000003898, OTTMUST00000071267
    Conserved Domains (2) summary
    cd08662
    Location:112761
    Blast Score: 2016
    M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
    COG3590
    Location:101754
    Blast Score: 1163
    PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]
  3. NM_177940.1NP_808809.1  endothelin-converting enzyme 2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2, also known as 2a-1) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b, also known as 2a-1) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC087898, AF489569, AF489572, AU080537, BC115541
    Consensus CDS
    CCDS49794.1
    UniProtKB/TrEMBL
    E9QKA6
    UniProtKB/TrEMBL
    Q80Z57
    UniProtKB/Swiss-Prot
    Q80Z60
    Related
    ENSMUSP00000078550, ENSMUST00000079600
    Conserved Domains (3) summary
    cd02440
    Location:61135
    Blast Score: 124
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    cd08662
    Location:230879
    Blast Score: 2017
    M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
    COG3590
    Location:219872
    Blast Score: 1157
    PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]
  4. NM_177941.1NP_808810.1  endothelin-converting enzyme 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, also known as 2a-2) represents the longest transcript and encodes the longest isoform (a, also known as 2a-2).
    Source sequence(s)
    AC087898, AF489570, AF489572, AU080537, BC115541
    Consensus CDS
    CCDS49793.1
    UniProtKB/TrEMBL
    E9PUE3
    UniProtKB/TrEMBL
    Q80Z57
    UniProtKB/Swiss-Prot
    Q80Z60
    Related
    ENSMUSP00000113475, OTTMUSP00000036480, ENSMUST00000120394, OTTMUST00000071264
    Conserved Domains (3) summary
    cd02440
    Location:61135
    Blast Score: 124
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    cd08662
    Location:259908
    Blast Score: 2016
    M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
    COG3590
    Location:248901
    Blast Score: 1155
    PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]
  5. NM_177942.1NP_808811.1  endothelin-converting enzyme 2 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5, also known as 2-b1) differs in the 5' UTR and CDS compared to variant 1. The resulting isoform (e, also known as 2b-1) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC087898, AF489571, AF489572, AU080537
    Consensus CDS
    CCDS49796.1
    UniProtKB/TrEMBL
    E9Q896
    UniProtKB/TrEMBL
    Q80Z57
    UniProtKB/TrEMBL
    Q80Z58
    Related
    ENSMUSP00000119693, OTTMUSP00000045569, ENSMUST00000133344, OTTMUST00000084539
    Conserved Domains (2) summary
    cd08662
    Location:83732
    Blast Score: 2017
    M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
    COG3590
    Location:72725
    Blast Score: 1165
    PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000082.6 

    Range
    20611601..20646480
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521692.1XP_006521755.1  

    Conserved Domains (2) summary
    cd08662
    Location:246841
    Blast Score: 1840
    M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
    COG3590
    Location:235854
    Blast Score: 1069
    PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]
  2. XM_006521697.1XP_006521760.1  

    Related
    ENSMUSP00000114039, OTTMUSP00000036484, ENSMUST00000122306, OTTMUST00000071268
    Conserved Domains (1) summary
    cd08662
    Location:246840
    Blast Score: 1823
    M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
  3. XM_006521695.1XP_006521758.1  

    Conserved Domains (1) summary
    cd08662
    Location:246807
    Blast Score: 1710
    M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
  4. XM_006521694.1XP_006521757.1  

    Conserved Domains (1) summary
    cd08662
    Location:246807
    Blast Score: 1710
    M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
  5. XM_006521696.1XP_006521759.1  

    Conserved Domains (1) summary
    cd08662
    Location:246839
    Blast Score: 1818
    M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
  6. XM_006521691.1XP_006521754.1  

    Conserved Domains (1) summary
    cd08662
    Location:246807
    Blast Score: 1710
    M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
  7. XM_006521693.1XP_006521756.1  

    Conserved Domains (1) summary
    cd08662
    Location:217778
    Blast Score: 1710
    M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
  8. XM_006521698.1XP_006521761.1  

    Conserved Domains (1) summary
    cd08662
    Location:246683
    Blast Score: 1084
    M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
  9. XM_006521701.1XP_006521764.1  

    Conserved Domains (1) summary
    pfam05649
    Location:249478
    Blast Score: 652
    Peptidase_M13_N; Peptidase family M13
  10. XM_006521699.1XP_006521762.1  

    Conserved Domains (1) summary
    cd08662
    Location:16459
    Blast Score: 1456
    M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
  11. XM_006521700.1XP_006521763.1  

    Conserved Domains (1) summary
    cd08662
    Location:1395
    Blast Score: 1316
    M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I

Alternate Mm_Celera

Genomic

  1. AC_000038.1 

    Range
    21175677..21210935
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)