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RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae) [ Homo sapiens (human) ]

Gene ID: 54700, updated on 26-Aug-2014
Official Symbol
RRN3provided by HGNC
Official Full Name
RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)provided by HGNC
Primary source
HGNC:30346
See related
Ensembl:ENSG00000085721; HPRD:12004; MIM:605121; Vega:OTTHUMG00000129847
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIFIA; A-270G1.2
See RRN3 in Epigenomics, MapViewer
Location:
16p12
Exon count:
18
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 16 NC_000016.10 (15060022..15094311, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (15153879..15188168, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene pyridoxal-dependent decarboxylase domain containing 1 Neighboring gene microRNA 1972-1 Neighboring gene N-terminal asparagine amidase Neighboring gene uncharacterized LOC100505915 Neighboring gene nuclear pore complex interacting protein pseudogene 1 Neighboring gene polycystic kidney disease 1 (autosomal dominant) pseudogene 6

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC104238, DKFZp566E104

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA polymerase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell proliferation IEA
Inferred from Electronic Annotation
more info
 
cytoplasm organization IEA
Inferred from Electronic Annotation
more info
 
gene expression TAS
Traceable Author Statement
more info
 
homeostasis of number of cells IEA
Inferred from Electronic Annotation
more info
 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator IEA
Inferred from Electronic Annotation
more info
 
nucleolus organization IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
regulation of DNA-templated transcription, initiation IEA
Inferred from Electronic Annotation
more info
 
ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
 
transcription from RNA polymerase I promoter TAS
Traceable Author Statement
more info
 
transcription initiation from RNA polymerase I promoter TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
Preferred Names
RNA polymerase I-specific transcription initiation factor RRN3
Names
RNA polymerase I-specific transcription initiation factor RRN3
TIF-IA
transcription initiation factor IA
transcription initiation factor TIF-IA

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301064.1NP_001287993.1  RNA polymerase I-specific transcription initiation factor RRN3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
    Source sequence(s)
    AK316520, BC036182, CK906270, DA764092, DC376629
    Consensus CDS
    CCDS73833.1
    Conserved Domains (1) summary
    pfam05327
    Location:45558
    Blast Score: 1557
    RRN3; RNA polymerase I specific transcription initiation factor RRN3
  2. NM_018427.4NP_060897.3  RNA polymerase I-specific transcription initiation factor RRN3 isoform 1

    See proteins identical to NP_060897.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC036182, BC132688, CK906270, DC376629
    Consensus CDS
    CCDS10559.1
    UniProtKB/Swiss-Prot
    Q9NYV6
    Related
    ENSP00000198767, OTTHUMP00000160284, ENST00000198767, OTTHUMT00000252087
    Conserved Domains (1) summary
    pfam05327
    Location:45588
    Blast Score: 1665
    RRN3; RNA polymerase I specific transcription initiation factor RRN3

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 ALT_REF_LOCI_1

Genomic

  1. NT_187607.1 

    Range
    575365..609658
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006725197.1XP_006725260.1  

    UniProtKB/TrEMBL
    F5H148
    Conserved Domains (1) summary
    pfam05327
    Location:45558
    Blast Score: 1557
    RRN3; RNA polymerase I specific transcription initiation factor RRN3
  2. XM_006725199.1XP_006725262.1  

    See proteins identical to XP_006725262.1

    Conserved Domains (1) summary
    pfam05327
    Location:7376
    Blast Score: 1194
    RRN3; RNA polymerase I specific transcription initiation factor RRN3
  3. XM_006725198.1XP_006725261.1  

    See proteins identical to XP_006725261.1

    Conserved Domains (1) summary
    pfam05327
    Location:7376
    Blast Score: 1194
    RRN3; RNA polymerase I specific transcription initiation factor RRN3

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000016.10 

    Range
    15060022..15094311
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005255375.1XP_005255432.1  

    UniProtKB/TrEMBL
    F5H148
    Conserved Domains (1) summary
    pfam05327
    Location:45558
    Blast Score: 1557
    RRN3; RNA polymerase I specific transcription initiation factor RRN3
  2. XM_005255377.2XP_005255434.1  

    See proteins identical to XP_005255434.1

    Conserved Domains (1) summary
    pfam05327
    Location:7376
    Blast Score: 1194
    RRN3; RNA polymerase I specific transcription initiation factor RRN3
  3. XM_005255376.1XP_005255433.1  

    See proteins identical to XP_005255433.1

    Conserved Domains (1) summary
    pfam05327
    Location:7376
    Blast Score: 1194
    RRN3; RNA polymerase I specific transcription initiation factor RRN3

Alternate HuRef

Genomic

  1. AC_000148.1 

    Range
    14799197..14833480
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018927.2 

    Range
    15095601..15129884
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)