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Srd5a1 steroid 5 alpha-reductase 1 [ Mus musculus (house mouse) ]

Gene ID: 78925, updated on 20-Feb-2015
Official Symbol
Srd5a1provided by MGI
Official Full Name
steroid 5 alpha-reductase 1provided by MGI
Primary source
MGI:MGI:98400
See related
Ensembl:ENSMUSG00000021594; Vega:OTTMUSG00000035506
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
S5AR 1; Srd5a-1; 0610031P22Rik; 4930435F02Rik
Orthologs
See Srd5a1 in MapViewer
Location:
13 C1; 13 35.55 cM
Exon count:
6
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 13 NC_000079.6 (69573449..69611900, complement)

Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A530095I07 gene Neighboring gene uncharacterized LOC105245548 Neighboring gene RAB geranylgeranyl transferase, b subunit pseudogene Neighboring gene NOL1/NOP2/Sun domain family member 2 Neighboring gene importin 7 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
3-oxo-5-alpha-steroid 4-dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
3-oxo-5-alpha-steroid 4-dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
NADPH binding ISO
Inferred from Sequence Orthology
more info
 
amide binding ISO
Inferred from Sequence Orthology
more info
 
cholestenone 5-alpha-reductase activity IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity, acting on the CH-CH group of donors IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
androgen biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
androgen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
androgen metabolic process ISO
Inferred from Sequence Orthology
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IMP
Inferred from Mutant Phenotype
more info
PubMed 
progesterone metabolic process ISO
Inferred from Sequence Orthology
more info
 
response to drug ISO
Inferred from Sequence Orthology
more info
 
sex differentiation IEA
Inferred from Electronic Annotation
more info
 
steroid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
steroid metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell body fiber ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
myelin sheath ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
3-oxo-5-alpha-steroid 4-dehydrogenase 1
Names
3-oxo-5-alpha-steroid 4-dehydrogenase 1
SR type 1
steroid 5-alpha-reductase 1
type 1 5alpha-reductase
NP_780492.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175283.3NP_780492.2  3-oxo-5-alpha-steroid 4-dehydrogenase 1

    See proteins identical to NP_780492.2

    Status: VALIDATED

    Source sequence(s)
    BB585840, BC079863
    Consensus CDS
    CCDS26624.1
    UniProtKB/Swiss-Prot
    Q68FF9
    Related
    ENSMUSP00000089097, OTTMUSP00000050010, ENSMUST00000091514, OTTMUST00000090926
    Conserved Domains (1) summary
    pfam02544
    Location:106255
    Steroid_dh; 3-oxo-5-alpha-steroid 4-dehydrogenase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000079.6 Reference GRCm38.p3 C57BL/6J

    Range
    69573449..69611900
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517474.2XP_006517537.1  

    Conserved Domains (1) summary
    cl21511
    Location:106184
    PEMT; Phospholipid methyltransferase
  2. XM_006517473.2XP_006517536.1  

    See proteins identical to XP_006517536.1

    UniProtKB/TrEMBL
    Q8BUR8
    Conserved Domains (1) summary
    cl21511
    Location:106183
    PEMT; Phospholipid methyltransferase

Alternate Mm_Celera

Genomic

  1. AC_000035.1 Alternate Mm_Celera

    Range
    71919533..71956201
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)