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Park2 Parkinson disease (autosomal recessive, juvenile) 2, parkin [ Mus musculus (house mouse) ]

Gene ID: 50873, updated on 26-Apr-2015
Official Symbol
Park2provided by MGI
Official Full Name
Parkinson disease (autosomal recessive, juvenile) 2, parkinprovided by MGI
Primary source
MGI:MGI:1355296
See related
Ensembl:ENSMUSG00000023826; Vega:OTTMUSG00000046340
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PRKN
Orthologs
See Park2 in MapViewer
Location:
17 A3.2-A3.3; 17 7.8 cM
Exon count:
15
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 17 NC_000083.6 (10840384..12063370)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (11033250..12256227)

Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene PARK2 co-regulated Neighboring gene predicted gene 16168 Neighboring gene uncharacterized protein C3orf18 homolog pseudogene Neighboring gene predicted gene 16169 Neighboring gene predicted gene 28505 Neighboring gene predicted gene, 41526 Neighboring gene predicted gene, 41525 Neighboring gene DNA segment, Chr 17, ERATO Doi 648, expressed Neighboring gene predicted gene, 35603 Neighboring gene predicted gene, 35547 Neighboring gene teratocarcinoma-derived growth factor, pseudogene 2 Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta) Neighboring gene mitogen-activated protein kinase kinase kinase 4

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC130518

Gene Ontology Provided by MGI

Function Evidence Code Pubs
F-box domain binding ISO
Inferred from Sequence Orthology
more info
 
G-protein coupled receptor binding ISO
Inferred from Sequence Orthology
more info
 
Hsp70 protein binding ISO
Inferred from Sequence Orthology
more info
 
PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity IEA
Inferred from Electronic Annotation
more info
 
actin binding ISO
Inferred from Sequence Orthology
more info
 
chaperone binding ISO
Inferred from Sequence Orthology
more info
 
coenzyme F420-0 gamma-glutamyl ligase activity IEA
Inferred from Electronic Annotation
more info
 
coenzyme F420-2 alpha-glutamyl ligase activity IEA
Inferred from Electronic Annotation
more info
 
cullin family protein binding ISO
Inferred from Sequence Orthology
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
heat shock protein binding ISO
Inferred from Sequence Orthology
more info
 
histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
kinase binding ISO
Inferred from Sequence Orthology
more info
 
ligase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phospholipase binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding ISO
Inferred from Sequence Orthology
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein-glutamic acid ligase activity IEA
Inferred from Electronic Annotation
more info
 
protein-glycine ligase activity IEA
Inferred from Electronic Annotation
more info
 
protein-glycine ligase activity, elongating IEA
Inferred from Electronic Annotation
more info
 
protein-glycine ligase activity, initiating IEA
Inferred from Electronic Annotation
more info
 
ribosomal S6-glutamic acid ligase activity IEA
Inferred from Electronic Annotation
more info
 
tubulin binding ISO
Inferred from Sequence Orthology
more info
 
tubulin-glutamic acid ligase activity IEA
Inferred from Electronic Annotation
more info
 
tubulin-glycine ligase activity IEA
Inferred from Electronic Annotation
more info
 
ubiquitin binding ISO
Inferred from Sequence Orthology
more info
 
ubiquitin conjugating enzyme binding ISO
Inferred from Sequence Orthology
more info
 
ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
ubiquitin-specific protease binding ISO
Inferred from Sequence Orthology
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
activation of mitophagy in response to mitochondrial depolarization ISO
Inferred from Sequence Orthology
more info
 
adult locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
aggresome assembly ISO
Inferred from Sequence Orthology
more info
 
autophagy IEA
Inferred from Electronic Annotation
more info
 
cellular protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
cellular response to toxic substance IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to toxic substance ISO
Inferred from Sequence Orthology
more info
 
dopamine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT dopamine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
dopamine uptake involved in synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitochondrion degradation ISO
Inferred from Sequence Orthology
more info
 
mitochondrion localization ISO
Inferred from Sequence Orthology
more info
 
negative regulation by host of viral genome replication ISO
Inferred from Sequence Orthology
more info
 
negative regulation of actin filament bundle assembly ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
negative regulation of glucokinase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron death IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
negative regulation of oxidative stress-induced neuron death ISO
Inferred from Sequence Orthology
more info
 
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of primary amine oxidase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of release of cytochrome c from mitochondria ISO
Inferred from Sequence Orthology
more info
 
negative regulation of spontaneous neurotransmitter secretion ISO
Inferred from Sequence Orthology
more info
 
norepinephrine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of DNA binding ISO
Inferred from Sequence Orthology
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of dendrite extension IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mitochondrial fusion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neurotransmitter uptake ISO
Inferred from Sequence Orthology
more info
 
positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of proteasomal protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein linear polyubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein linear polyubiquitination ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
protein K11-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
protein K6-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
protein K63-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
 
protein localization to mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to mitochondrion ISO
Inferred from Sequence Orthology
more info
 
protein metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein monoubiquitination ISO
Inferred from Sequence Orthology
more info
 
protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
 
protein stabilization ISO
Inferred from Sequence Orthology
more info
 
protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
protein ubiquitination involved in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
regulation of cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
regulation of dopamine metabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of mitochondrial membrane potential IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of mitochondrion organization ISO
Inferred from Sequence Orthology
more info
 
regulation of neurotransmitter secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein targeting to mitochondrion ISO
Inferred from Sequence Orthology
more info
 
regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 
response to unfolded protein ISO
Inferred from Sequence Orthology
more info
 
startle response IMP
Inferred from Mutant Phenotype
more info
PubMed 
synaptic transmission, dopaminergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
synaptic transmission, glutamatergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
Golgi membrane ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with LUBAC complex ISO
Inferred from Sequence Orthology
more info
 
Parkin-FBXW7-Cul1 ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
aggresome ISO
Inferred from Sequence Orthology
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell projection IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
intracellular ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
membrane raft ISO
Inferred from Sequence Orthology
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with mitochondrion ISO
Inferred from Sequence Orthology
more info
 
neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
protein complex IDA
Inferred from Direct Assay
more info
PubMed 
synapse ISO
Inferred from Sequence Orthology
more info
 
synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 
ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
E3 ubiquitin-protein ligase parkin
Names
E3 ubiquitin-protein ligase parkin
parkin protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016694.3NP_057903.1  E3 ubiquitin-protein ligase parkin

    See identical proteins and their annotated locations for NP_057903.1

    Status: PROVISIONAL

    Source sequence(s)
    AC091254, AC091484, AC091777, AC093450, AC105305, AC122259, AC163687, CT009575
    UniProtKB/Swiss-Prot
    Q9WVS6
    Related
    ENSMUSP00000140587, OTTMUSP00000066774, ENSMUST00000191124, OTTMUST00000120776
    Conserved Domains (3) summary
    cd01798
    Location:372
    parkin_N; amino-terminal ubiquitin-like of parkin protein
    smart00647
    Location:313374
    IBR; In Between Ring fingers
    pfam01485
    Location:411452
    IBR; IBR domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000083.6 Reference GRCm38.p3 C57BL/6J

    Range
    10840384..12063370
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523340.1XP_006523403.1  

    See identical proteins and their annotated locations for XP_006523403.1

    UniProtKB/Swiss-Prot
    Q9WVS6
    Conserved Domains (1) summary
    cd01798
    Location:372
    parkin_N; amino-terminal ubiquitin-like of parkin protein
  2. XM_006523339.2XP_006523402.1  

    Conserved Domains (1) summary
    smart00647
    Location:123184
    IBR; In Between Ring fingers
  3. XM_006523336.2XP_006523399.1  

    Conserved Domains (3) summary
    cd01798
    Location:372
    parkin_N; amino-terminal ubiquitin-like of parkin protein
    smart00647
    Location:314375
    IBR; In Between Ring fingers
    pfam01485
    Location:412453
    IBR; IBR domain
  4. XM_006523334.2XP_006523397.2  

    Conserved Domains (3) summary
    cd01798
    Location:675
    parkin_N; amino-terminal ubiquitin-like of parkin protein
    smart00647
    Location:317378
    IBR; In Between Ring fingers
    pfam01485
    Location:415456
    IBR; IBR domain
  5. XM_006523335.2XP_006523398.2  

    Conserved Domains (3) summary
    cd01798
    Location:675
    parkin_N; amino-terminal ubiquitin-like of parkin protein
    smart00647
    Location:316377
    IBR; In Between Ring fingers
    pfam01485
    Location:414455
    IBR; IBR domain
  6. XM_006523338.2XP_006523401.2  

    Conserved Domains (1) summary
    cd01798
    Location:675
    parkin_N; amino-terminal ubiquitin-like of parkin protein
  7. XM_006523337.2XP_006523400.1  

    Conserved Domains (1) summary
    smart00647
    Location:183244
    IBR; In Between Ring fingers

Alternate Mm_Celera

Genomic

  1. AC_000039.1 Alternate Mm_Celera

    Range
    10880667..12092859
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)