Display Settings:

Format

Send to:

Choose Destination

MT3 metallothionein 3 [ Homo sapiens (human) ]

Gene ID: 4504, updated on 13-Jan-2015
Official Symbol
MT3provided by HGNC
Official Full Name
metallothionein 3provided by HGNC
Primary source
HGNC:HGNC:7408
See related
Ensembl:ENSG00000087250; HPRD:00752; MIM:139255; Vega:OTTHUMG00000133282
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GIF; GIFB; GRIF; ZnMT3
Orthologs
See MT3 in MapViewer
Location:
16q13
Exon count:
3
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 16 NC_000016.10 (56589355..56591088)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (56623267..56625000)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene 2-oxoglutarate and iron-dependent oxygenase domain containing 1 Neighboring gene Bardet-Biedl syndrome 2 Neighboring gene metallothionein 4 Neighboring gene metallothionein 2A Neighboring gene metallothionein 1L (gene/pseudogene)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including Metallothionein, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection PubMed
Vpr vpr Treatment of human primary astrocytes with HIV-1 Vpr downregulates expression of eleven genes, BNIP3, CYGB, DUOX2, DUSP1, FOXM1, GAPDH, HPRT1, MT3, MTL5, PTGS2, and SCARA3 PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
antioxidant activity NAS
Non-traceable Author Statement
more info
PubMed 
cadmium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
copper ion binding IDA
Inferred from Direct Assay
more info
PubMed 
copper ion binding TAS
Traceable Author Statement
more info
PubMed 
cysteine-type endopeptidase inhibitor activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
drug binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
activation of protein kinase B activity IDA
Inferred from Direct Assay
more info
PubMed 
astrocyte development ISS
Inferred from Sequence or Structural Similarity
more info
 
cadmium ion homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
cell proliferation TAS
Traceable Author Statement
more info
PubMed 
cellular lipid catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular metal ion homeostasis NAS
Non-traceable Author Statement
more info
PubMed 
cellular metal ion homeostasis TAS
Traceable Author Statement
more info
PubMed 
cellular response to cadmium ion IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to drug IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to nitric oxide IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to oxidative stress IEP
Inferred from Expression Pattern
more info
PubMed 
cellular zinc ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
cholesterol catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
energy reserve metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
histone modification IMP
Inferred from Mutant Phenotype
more info
PubMed 
leptin-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of autophagy ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of axon extension IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell growth IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell growth TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cysteine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of necrotic cell death IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of necrotic cell death ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of oxidoreductase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of reactive oxygen species metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of catalytic activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell death IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell death ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of lysosomal membrane permeability ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of necrotic cell death IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of oxygen metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of vascular endothelial growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
protein import into nucleus, translocation IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase B signaling IDA
Inferred from Direct Assay
more info
PubMed 
protein stabilization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of protein glycosylation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of response to food ISS
Inferred from Sequence or Structural Similarity
more info
 
removal of superoxide radicals IDA
Inferred from Direct Assay
more info
PubMed 
response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion transport ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
inclusion body IDA
Inferred from Direct Assay
more info
PubMed 
intracellular IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
synaptic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
metallothionein-3
Names
metallothionein-3
MT-3
MT-III
metallothionein-III
growth inhibitory factor
metallothionein 3 (growth inhibitory factor (neurotrophic))

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005954.2NP_005945.1  metallothionein-3

    See proteins identical to NP_005945.1

    Status: VALIDATED

    Source sequence(s)
    BC013081, BI752092, BI820409, CB155600
    Consensus CDS
    CCDS10762.1
    UniProtKB/TrEMBL
    A0A024R6R7
    UniProtKB/Swiss-Prot
    P25713
    Related
    ENSP00000200691, OTTHUMP00000164383, ENST00000200691, OTTHUMT00000257062
    Conserved Domains (1) summary
    pfam00131
    Location:368
    Metallothio; Metallothionein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000016.10 

    Range
    56589355..56591088
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018927.2 

    Range
    58029740..58031473
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000148.1 

    Range
    42492901..42494634
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)