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Rps6ka2 ribosomal protein S6 kinase, polypeptide 2 [ Mus musculus (house mouse) ]

Gene ID: 20112, updated on 17-Mar-2015
Official Symbol
Rps6ka2provided by MGI
Official Full Name
ribosomal protein S6 kinase, polypeptide 2provided by MGI
Primary source
MGI:MGI:1342290
See related
Ensembl:ENSMUSG00000023809
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rsk3; 90kDa; p90rsk; pp90rsk; D17Wsu134e; Rps6ka-rs1
See Rps6ka2 in MapViewer
Location:
17 4.7 cM; 17 F4
Exon count:
23
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 17 NC_000083.6 (7088975..7303315)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (7374464..7507664)

Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene ribonuclease T2B Neighboring gene predicted gene 1604b Neighboring gene G protein-coupled receptor 31, D17Leh66a region Neighboring gene t-complex protein 10a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine/tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
ribosomal protein S6 kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity, transferring phosphorus-containing groups IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
brain renin-angiotensin system IDA
Inferred from Direct Assay
more info
PubMed 
cardiac muscle cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to carbohydrate stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to stress IBA
Inferred from Biological aspect of Ancestor
more info
 
heart contraction IDA
Inferred from Direct Assay
more info
PubMed 
heart development IDA
Inferred from Direct Assay
more info
PubMed 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
negative regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of meiotic nuclear division IDA
Inferred from Direct Assay
more info
PubMed 
oocyte maturation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of protein processing IDA
Inferred from Direct Assay
more info
PubMed 
regulation of protein processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
spindle IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
ribosomal protein S6 kinase alpha-2
Names
ribosomal protein S6 kinase alpha-2
90 kDa ribosomal protein S6 kinase 2
MAP kinase-activated protein kinase 1c
MAPK-activated protein kinase 1c
MAPKAP kinase 1c
MAPKAPK-1c
RSK-3
S6K-alpha 2
S6K-alpha-2
p90-RSK 2
p90RSK2
pp90RSK3
protein-tyrosine kinase Mpk-9
ribosomal S6 kinase 3
ribosomal protein S6 kinase alpha 2
ribosomal protein S6 kinase, 90kD, polypeptide 2
NP_035429.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011299.4NP_035429.1  ribosomal protein S6 kinase alpha-2

    See proteins identical to NP_035429.1

    Status: VALIDATED

    Source sequence(s)
    BC043064, BC055331
    Consensus CDS
    CCDS28376.1
    UniProtKB/TrEMBL
    Q7TPD5
    UniProtKB/Swiss-Prot
    Q9WUT3
    Related
    ENSMUSP00000024575, ENSMUST00000024575
    Conserved Domains (3) summary
    smart00220
    Location:59318
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05582
    Location:63379
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14178
    Location:411703
    STKc_RSK3_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 3 (also called Ribosomal protein S6 kinase alpha-2 or 90kDa ribosomal protein S6 kinase 2)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000083.6 Reference GRCm38.p3 C57BL/6J

    Range
    7088975..7303315
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523199.2XP_006523262.1  

    Conserved Domains (3) summary
    smart00220
    Location:42301
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05582
    Location:46362
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14178
    Location:394686
    STKc_RSK3_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 3 (also called Ribosomal protein S6 kinase alpha-2 or 90kDa ribosomal protein S6 kinase 2)
  2. XM_006523201.1XP_006523264.1  

    See proteins identical to XP_006523264.1

    Conserved Domains (3) summary
    smart00220
    Location:308565
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14178
    Location:304596
    STKc_RSK3_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 3 (also called Ribosomal protein S6 kinase alpha-2 or 90kDa ribosomal protein S6 kinase 2)
    cl21453
    Location:1272
    PKc_like; Catalytic domain of the Protein Kinase superfamily
  3. XM_006523198.2XP_006523261.1  

    Conserved Domains (3) summary
    smart00220
    Location:43302
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05582
    Location:47363
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14178
    Location:395687
    STKc_RSK3_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 3 (also called Ribosomal protein S6 kinase alpha-2 or 90kDa ribosomal protein S6 kinase 2)
  4. XM_006523200.1XP_006523263.1  

    See proteins identical to XP_006523263.1

    Conserved Domains (3) summary
    smart00220
    Location:308565
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14178
    Location:304596
    STKc_RSK3_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 3 (also called Ribosomal protein S6 kinase alpha-2 or 90kDa ribosomal protein S6 kinase 2)
    cl21453
    Location:1272
    PKc_like; Catalytic domain of the Protein Kinase superfamily

Alternate Mm_Celera

Genomic

  1. AC_000039.1 Alternate Mm_Celera

    Range
    7033227..7165891
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)